Yanping Chen
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View article: Differences of clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma and additional primary tumours
Differences of clinical features, prognosis and genetic mutations in Chinese patients with malignant melanoma and additional primary tumours Open
The frequency of MM and additional primary tumours is about 5% in Chinese populations. Patients with melanoma diagnosed first have longer melanoma survival. Digestive system tumours were the most concomitant; a digestive examination is adv…
View article: Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography
Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography Open
Our results indicate that OCT and its extensions effectively analyze dermal fibrosis. OCE revealed increased stiffness in fibrotic skin, OCTA showed vessel dilation, and OCT noted morphological changes in fibrosis tissue.
View article: Precision medicine in the prediction of metachronous liver metastasis in rectal cancer: Applications and challenges
Precision medicine in the prediction of metachronous liver metastasis in rectal cancer: Applications and challenges Open
Rectal cancer is a major global health concern, and metachronous liver metastasis (MLM) significantly worsens patient prognosis. Advances in imaging and machine learning have led to the development of radiomics models, particularly those u…
View article: Gender differences in preferences, gateway effects, and potential motivations among e-cigarette users in China
Gender differences in preferences, gateway effects, and potential motivations among e-cigarette users in China Open
Objective A cross-sectional survey was conducted to investigate the differences in preferences, gateway effects, and potential motivations for e-cigarette use among different genders of e-cigarette users in China, thereby providing ideas f…
View article: Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage
Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage Open
Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax. We performed assays to assess cell viability, apoptosis, glyc…
View article: Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults
Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults Open
In a highly myopic population, both BCVA and VF deteriorated over time, with increasing MSVI incidence. Raising public awareness of vision risks linked to high myopia and implementing strategies to reduce the burden in high-risk individual…
View article: Correction: Segmentation of HE-stained meningioma pathological images based on pseudo-labels
Correction: Segmentation of HE-stained meningioma pathological images based on pseudo-labels Open
[This corrects the article DOI: 10.1371/journal.pone.0263006.].
View article: IGF2BP1 accelerates the aerobic glycolysis to boost its immune escape in hepatocellular carcinoma microenvironment
IGF2BP1 accelerates the aerobic glycolysis to boost its immune escape in hepatocellular carcinoma microenvironment Open
Introduction Energy metabolism abnormity emerges as a crucial factor that facilitates tumorigenesis by accelerating aerobic glycolysis. However, the function of N 6 -methyladenosine (m 6 A) on hepatocellular carcinoma (HCC) aerobic glycoly…
View article: Supplementary Figures from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers
Supplementary Figures from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers Open
Supplementary Figures S1-S5
View article: Data from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers
Data from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers Open
Whether there is an association between SWI/SNF genomic alterations in tumors and response to immune checkpoint inhibitors (ICIs) remains unclear because prior studies have focused on either an individual gene or a predefined set of genes.…
View article: Supplementary Figures from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers
Supplementary Figures from SWI/SNF complex genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers Open
Supplementary Figures S1-S5
View article: Inflammation-related markers and prognosis of alpha-fetoprotein producing gastric cancer
Inflammation-related markers and prognosis of alpha-fetoprotein producing gastric cancer Open
BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index …
View article: Ide-cel vs standard regimens in triple-class–exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses
Ide-cel vs standard regimens in triple-class–exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses Open
Outcomes are poor in triple-class–exposed (TCE) relapsed and refractory multiple myeloma (R/RMM). In the phase 3 KarMMa-3 trial, patients with TCE R/RMM and 2 to 4 prior regimens were randomized 2:1 to idecabtagene vicleucel (ide-cel) or s…
View article: Multimodal Representation of Online Dictionaries to Assist Medical English Listening, Speaking, and Viewing Classroom
Multimodal Representation of Online Dictionaries to Assist Medical English Listening, Speaking, and Viewing Classroom Open
Multimodality refers to the blend of different symbol systems, like music and text, used in communication or behavior. Modality is how humans interact with the external environment, like objects, animals, or machines, through their senses,…
View article: Based on Immune Microenvironment and Genomic Status, Exploring Immunotherapy in Advanced Hidradenocarcinoma: A Retrospective Analysis
Based on Immune Microenvironment and Genomic Status, Exploring Immunotherapy in Advanced Hidradenocarcinoma: A Retrospective Analysis Open
There are no standard treatment guidelines for hidradenocarcinoma, and the immune microenvironment and genomic data are very limited. Thus, in this study the immune microenvironment and genomic indicators in hidradenocarcinoma was investig…
View article: A four-gene signature predicts overall survival of patients with esophageal adenocarcinoma
A four-gene signature predicts overall survival of patients with esophageal adenocarcinoma Open
The four-gene signature identified in the current study may be a potential prognostic factor for predicting OS of EAC patients.
View article: Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature
Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature Open
BACKGROUND The prevalence of multiple primary malignant neoplasms (MPMNs) is increasing in parallel with the incidence of malignancies, the continual improvement of diagnostic models, and the extended life of patients with tumors, especial…
View article: S193: BMS-986393 (CC-95266), A G PROTEIN–COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D (GPRC5D)–TARGETED CAR T-CELL THERAPY FOR RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): RESULTS FROM A PHASE 1 STUDY
S193: BMS-986393 (CC-95266), A G PROTEIN–COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D (GPRC5D)–TARGETED CAR T-CELL THERAPY FOR RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): RESULTS FROM A PHASE 1 STUDY Open
Background: While chimeric antigen receptor (CAR) T-cell therapies targeting B-cell maturation antigen (BCMA) have shown deep and durable responses in RRMM, new targets are needed as most patients (pts) relapse. GPRC5D, an orphan receptor …
View article: The clinical significance of SNAIL, TWIST, and E-Cadherin expression in gastric mesentery tumor deposits of advanced gastric cancer
The clinical significance of SNAIL, TWIST, and E-Cadherin expression in gastric mesentery tumor deposits of advanced gastric cancer Open
Objective: To explore the relationships among the epithelial to mesenchymal transition (EMT)-related factors (SNAIL, TWIST, and E-Cadherin) and clinicopathological parameters and gastric mesangial tumor deposits (TDs) in advanced gastric c…
View article: Semi-supervised nuclei segmentation based on multi-edge features fusion attention network
Semi-supervised nuclei segmentation based on multi-edge features fusion attention network Open
The morphology of the nuclei represents most of the clinical pathological information, and nuclei segmentation is a vital step in current automated histopathological image analysis. Supervised machine learning-based segmentation models hav…
View article: Supplementary Figures from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Supplementary Figures from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers Open
Supplementary Figures S1-S5
View article: Data from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Data from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers Open
Whether there is an association between SWI/SNF genomic alterations in tumors and response to immune checkpoint inhibitors (ICI) remains unclear because prior studies have focused on either an individual gene or a predefined set of genes. …
View article: Supplementary Tables from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Supplementary Tables from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers Open
Supplementary Tables S1-S12
View article: Supplementary Tables from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers
Supplementary Tables from SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers Open
Supplementary Tables S1-S12