Yanping Guo
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View article: Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation
Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation Open
The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB. Unraveling how …
View article: A clinically interpretable model derived from skin conductance for assessing microangiopathy of the skin surface
A clinically interpretable model derived from skin conductance for assessing microangiopathy of the skin surface Open
The electrical properties of the skin can reflect changes in its structure and physiological state, and bioimpedance analysis has been widely used to distinguish specific components of the human body, such as water, fat, or muscle tissue, …
View article: Safety and Efficacy of a New Hyaluronic Acid Filler for Lip Augmentation: A Prospective, Multicenter, Randomized, Controlled Study
Safety and Efficacy of a New Hyaluronic Acid Filler for Lip Augmentation: A Prospective, Multicenter, Randomized, Controlled Study Open
Background Lip augmentation has become increasingly accepted and popular. However, there are still a few approved lip fillers that are versatile, biocompatible, suitable for lip enhancement, and backed by large-scale clinical trials. Objec…
View article: Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression
Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression Open
BACKGROUND Urinary system tumors often cause negative psychological symptoms, such as depression and dysphoria which significantly impact immune function and indirectly affect cancer prognosis. While epirubicin (EPI) is recommended by the …
View article: Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing
Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing Open
ACHA is an effective and safe hyaluronic acid for patients with minimal to severe temple hollowing.
View article: Recurrent mucinous carcinoma with sarcomatoid and sarcomatous mural nodules: a case report and literature review
Recurrent mucinous carcinoma with sarcomatoid and sarcomatous mural nodules: a case report and literature review Open
Ovarian mucinous tumors with sarcomatous mural nodules are rare. Sarcomatous nodules have a bad prognosis. Its diagnosis and treatment are controversial.It is still controversial whether malignant mural nodules represent a dedifferentiated…
View article: Study on the Coupled Dynamic Evolution of Social Entrepreneurship and Rural Labor Return in the Context of Rural Revitalization
Study on the Coupled Dynamic Evolution of Social Entrepreneurship and Rural Labor Return in the Context of Rural Revitalization Open
Based on the panel data of social entrepreneurship and rural labor force return in 31 provinces and municipalities in China from 2016-2021, this paper constructs the evaluation system of entrepreneurial activity from the perspective of rur…
View article: Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth
Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth Open
Early life is a time of increased susceptibility to infectious diseases and development of allergy. Innate lymphocytes are crucial components of the initiation and regulation of immune responses at mucosal surfaces, but functional differen…
View article: Involvement of a rice mutation GPGG1 in storage protein biogenesis in endosperm and its location in rice genome
Involvement of a rice mutation GPGG1 in storage protein biogenesis in endosperm and its location in rice genome Open
In the wild type of rice endosperm cell, glutelins and prolamins are synthesized on the respective subdomains of rough endoplasmic-reticulum (ER) and intracellularly compartmentalized into the different storage protein bodies, respectively…
View article: Increasing human monoclonal antibody cloning efficiency with a whole-cell modified immunoglobulin-capture assay (mICA)
Increasing human monoclonal antibody cloning efficiency with a whole-cell modified immunoglobulin-capture assay (mICA) Open
Expression cloning of fully human monoclonal antibodies (hmAbs) is seeing powerful utility in the field of vaccinology, especially for elucidating vaccine-induced B-cell responses and novel vaccine candidate antigen discovery. Precision of…
View article: Botulinum toxin type A alleviates androgenetic alopecia by inhibiting apoptosis of dermal papilla cells via targeting circ_0135062/miR-506-3p/Bax axis
Botulinum toxin type A alleviates androgenetic alopecia by inhibiting apoptosis of dermal papilla cells via targeting circ_0135062/miR-506-3p/Bax axis Open
Botulinum toxin type A (BTXA) has been shown to be effective in androgenetic alopecia (AGA), but its effect on dermal papillary cell (DPC) apoptosis is not yet clear. Non-coding RNA plays pivotal roles in the development of AGA. In this st…
View article: Identification and Verification of Immune Subtype-Related lncRNAs in Clear Cell Renal Cell Carcinoma
Identification and Verification of Immune Subtype-Related lncRNAs in Clear Cell Renal Cell Carcinoma Open
Background According to clinical study results, immune checkpoint blockade (ICB) treatment enhances the survival outcome of patients with clear cell renal cell carcinoma (ccRCC). Previous research has divided ccRCC patients into immune sub…
View article: Alterations in B- and circulating T-follicular helper cell subsets in immune thrombotic thrombocytopenic purpura
Alterations in B- and circulating T-follicular helper cell subsets in immune thrombotic thrombocytopenic purpura Open
T follicular helper (Tfh) cells regulate development of antigen-specific B-cell immunity. We prospectively investigated B-cell and circulating Tfh (cTfh) cell subsets in 45 patients with immune thrombotic thrombocytopenic purpura (iTTP) at…
View article: Exosomal microRNA⁃93⁃3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing
Exosomal microRNA⁃93⁃3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing Open
Wounds are soft tissue injuries, which are difficult to heal and can easily lead to other skin diseases. Bone marrow mesenchymal stem cells (BMSCs) and the secreted exosomes play a key role in skin wound healing. This study aims to clarify…
View article: Defining the Role of Cellular Immune Signatures in Diagnostic Evaluation of Suspected Tuberculosis
Defining the Role of Cellular Immune Signatures in Diagnostic Evaluation of Suspected Tuberculosis Open
Background Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a significant challenge, particularly in high-income, low-incidence settings. Measurement of Mycobacterium tuberculosis (Mtb)-specific cellular immune …
View article: Dynamic Changes in Serum Inhibin B Levels in 6- to 24-Month-Old Children Receiving Cryptorchidism Surgery
Dynamic Changes in Serum Inhibin B Levels in 6- to 24-Month-Old Children Receiving Cryptorchidism Surgery Open
Serum inhibin B can be used as a short-term evaluation index of cryptorchidism surgery rather than as a long-term indicator.
View article: Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis Open
Renal cell carcinoma (RCC) has the highest mortality rate among urological cancers and tumor angiogenesis that plays a critical role in RCC progress. Epidermal growth factor-like domain multiple 7 (EGFL7) has been recently identified as a …
View article: Cell cycle corruption in a pre-leukemic ETV6-RUNX1 model exposes RUNX1 addiction as a therapeutic target in acute lymphoblastic leukemia
Cell cycle corruption in a pre-leukemic ETV6-RUNX1 model exposes RUNX1 addiction as a therapeutic target in acute lymphoblastic leukemia Open
Summary The ETV6-RUNX1 onco-fusion arises in utero , initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrat…
View article: Evaluation of Risk Factors for Venous Thromboembolism in Patients Who Underwent Gynecological Surgery and Validation of a Fast-Rating Assessment Table
Evaluation of Risk Factors for Venous Thromboembolism in Patients Who Underwent Gynecological Surgery and Validation of a Fast-Rating Assessment Table Open
BACKGROUND: The aim of this study was to retrospectively analyze the risk factors for venous thromboembolism (VTE) in gynecological patients and verify the validity of a fast-rating assessment table. MATERIAL/METHODS: From October 2015 to …
View article: OMIP‐062: A 14‐Color, 16‐Antibody Panel for Immunophenotyping Human Innate Lymphoid, Myeloid and T Cells in Small Volumes of Whole Blood and Pediatric Airway Samples
OMIP‐062: A 14‐Color, 16‐Antibody Panel for Immunophenotyping Human Innate Lymphoid, Myeloid and T Cells in Small Volumes of Whole Blood and Pediatric Airway Samples Open
This 14‐color, 16‐antibody OMIP was designed for enumeration of leukocyte responses in pediatric samples, where sample volumes and cell numbers can be very low. Leukocytes identified by this panel include all major members of the innate ly…
View article: Influence of shading on photosynthesis and antioxidative activities of enzymes in apple trees
Influence of shading on photosynthesis and antioxidative activities of enzymes in apple trees Open
This study investigated the effects of shading on photosynthesis in 3-year-old potted apple trees. The trees were grown either in full sunlight or in a shade environment with about 50% of sunlight filtered through black plastic nets. Under…
View article: Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation Open
Background: Autosomal dominant optic atrophy (ADOA) is usually caused by mutations in the essential gene, OPA1. This encodes a ubiquitous protein involved in mitochondrial dynamics, hence tissue specificity is not understood. Dysregulated …