Yanqi Dang
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View article: Emodin Enhances Rosiglitazone’s Therapeutic Profile by Dual Modulation of SREBP1-Mediated Adipogenesis and PPARγ-Driven Thermogenesis
Emodin Enhances Rosiglitazone’s Therapeutic Profile by Dual Modulation of SREBP1-Mediated Adipogenesis and PPARγ-Driven Thermogenesis Open
Background/Objectives: Rosiglitazone (RSG), a potent PPARγ agonist for type 2 diabetes mellitus (T2DM), induces adverse adipogenic effects that limit clinical use. We investigated whether emodin (1,3,8-trihydroxy-6-methylanthraquinone, EMO…
View article: <i>iMeta</i> Conference 2025: Creating high‐impact international journals
<i>iMeta</i> Conference 2025: Creating high‐impact international journals Open
View article: Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5‐Hydroxymethylcytosine‐Mediated Sp1 Transcription Factor Expression
Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5‐Hydroxymethylcytosine‐Mediated Sp1 Transcription Factor Expression Open
Cellular senescence is a significant contributor to various age‐related diseases. Tet methylcytosine dioxygenase 3 (TET3) is a pivotal regulator of epigenetic modifications, and this study aimed to elucidate its role in cellular senescence…
View article: Risk of gastric cancer in autoimmune gastritis and pernicious anaemia: Insights from Mendelian randomization and multi‐omics analysis
Risk of gastric cancer in autoimmune gastritis and pernicious anaemia: Insights from Mendelian randomization and multi‐omics analysis Open
Background The newly onset debate surrounding the risk of gastric cancer (GC) in autoimmune gastritis (AIG) and pernicious anaemia has intensified. It is necessary to supplement higher level research evidences to settle this issue. Methods…
View article: Regulation of histone H3K27 methylation in inflammation and cancer
Regulation of histone H3K27 methylation in inflammation and cancer Open
View article: Colorectal Cancer: Pathogenesis and Targeted Therapy
Colorectal Cancer: Pathogenesis and Targeted Therapy Open
Colorectal cancer (CRC) ranks among the most prevalent malignant neoplasms globally. A growing body of evidence underscores the pivotal roles of genetic alterations and dysregulated epigenetic modifications in the pathogenesis of CRC. In r…
View article: Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice
Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice Open
View article: Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies Open
Metabolism‐related diseases, including diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease, are becoming increasingly prevalent, thereby posing significant threats to human health and longevity. Proteins, as th…
View article: Copper homeostasis and cuproptosis in health and disease
Copper homeostasis and cuproptosis in health and disease Open
Copper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation of various biological processes. Regulation of copper levels within a narrow range is imperative for ma…
View article: Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors
Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors Open
The emergence of immunotherapy, particularly immune checkpoint inhibitors (ICIs), represents a groundbreaking approach to treating gastric cancer (GC). However, the prognosis of GC patients receiving ICI treatment is influenced by various …
View article: Gan-jiang-ling-zhu decoction improves steatohepatitis by regulating gut microbiota-mediated 12-tridecenoic acid inhibition
Gan-jiang-ling-zhu decoction improves steatohepatitis by regulating gut microbiota-mediated 12-tridecenoic acid inhibition Open
Introduction: Gan–jiang–ling–zhu (GJLZ) decoction is a classical traditional Chinese medicine prescription. Through invigorating yang , activating qi and dissipating dampness , GJLZ decoction is widely applied for the treatment of chronic …
View article: Editorial: Application of genomics and epigenetics in disease and syndrome classification
Editorial: Application of genomics and epigenetics in disease and syndrome classification Open
Keywords: disease classification, syndrome classification, genomics, DNA methylation, RNA methylation, protein modification
View article: The role of N6-methyladenosine in macrophage polarization: A novel treatment strategy for non-alcoholic steatohepatitis
The role of N6-methyladenosine in macrophage polarization: A novel treatment strategy for non-alcoholic steatohepatitis Open
RNA methylation modifications, as a widespread type of modification in eukaryotic cells, especially N6-methyladenosine (m6A), are associated with many activities in organisms, including macrophage polarization and progression of…
View article: Targeted metabolomics revealed the mechanisms underlying the role of Liansu capsule in ameliorating functional dyspepsia
Targeted metabolomics revealed the mechanisms underlying the role of Liansu capsule in ameliorating functional dyspepsia Open
Our findings indicated that Liansu capsule improved FD by regulating the deoxycholic acid/hyodeoxycholic acid-TGR5-STAT3-KLF5 axis. The findings reveal a novel mechanism underlying the role of Liansu capsule, which may be a promising thera…
View article: Impact of smoking cessation on non-alcoholic fatty liver disease prevalence: a systematic review and meta-analysis
Impact of smoking cessation on non-alcoholic fatty liver disease prevalence: a systematic review and meta-analysis Open
Objectives The negative effects of smoking on numerous cardiovascular and metabolic diseases have been widely acknowledged. However, the potential effect of smoking cessation is relatively unelucidated. The objective of this study is to ex…
View article: tRNA‐derived fragments are promising biomarkers for screening of early colorectal cancer
tRNA‐derived fragments are promising biomarkers for screening of early colorectal cancer Open
Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer-related death globally.1 In the clinical setting, early screening of CRC is vital for subsequent management. Conventional serum biomarkers s…
View article: Dynamic changes in DNA methylation and hydroxymethylation revealed the transformation of advanced adenoma into colorectal carcinoma
Dynamic changes in DNA methylation and hydroxymethylation revealed the transformation of advanced adenoma into colorectal carcinoma Open
Globally, colorectal carcinoma (CRC) ranks third in terms of prevalence according to the latest Global Cancer Statistics.1 Studies have shown that most CRCs begin as preexisting adenomas,2 among which advanced adenomas (AAs) have been demo…
View article: Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites
Lingguizhugan decoction improves non-alcoholic steatohepatitis partially by modulating gut microbiota and correlated metabolites Open
Background Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis (NASH). However, the anti-NASH effect…
View article: Roles of gut microbiota and metabolites in overweight and obesity of children
Roles of gut microbiota and metabolites in overweight and obesity of children Open
The prevalence of overweight and obesity in children and adolescents is an increasing public health problem. Pediatric overweight and obesity result from multiple factors, including genetic background, diet, and lifestyle. In addition, the…
View article: The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis
The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis Open
View article: Recent advances in lean NAFLD
Recent advances in lean NAFLD Open
As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the most pivotal role in NAFLD, approximately 10-20% of individuals…
View article: Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease
Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD …
View article: METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis
METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis Open
View article: Additional file 5 of METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis
Additional file 5 of METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis Open
Additional file 5. mRNA methylation level in colorectal carcinoma vs. normal tissue.
View article: Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology
Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology Open
View article: CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis
CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis Open
The expression of circ_0084927 is significantly increased in CRC and higher in advanced-stage CRC than in early-stage CRC. Moreover, circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/ AKT/mTOR path…
View article: METTL3 Facilitates Colorectal Carcinoma Progression via Regulating m6A-CRB3-Hippo Axis
METTL3 Facilitates Colorectal Carcinoma Progression via Regulating m6A-CRB3-Hippo Axis Open
Background Colorectal carcinoma (CRC) is the third most common cancer and the second most common cause of cancer-related death worldwide. RNA N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) play an important role in cancer. H…
View article: Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease
Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease Open
Alcoholic liver disease (ALD) is a liver disease caused by long-term alcohol consumption. ROS-mediated oxidative stress is the leading cause of ALD. Pien-Tze-Huang (PZH), a traditional formula, is famous in China. This study was designed t…
View article: Gut Microbiota and Related Metabolites Were Disturbed in Ulcerative Colitis and Partly Restored After Mesalamine Treatment
Gut Microbiota and Related Metabolites Were Disturbed in Ulcerative Colitis and Partly Restored After Mesalamine Treatment Open
Mesalamine has been well used in the improvement of ulcerative colitis (UC) in clinics, however, the underlying mechanisms were not well illustrated. To explore its efficacy from the perspective of gut microbiota and related metabolites, w…
View article: Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice
Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice Open
Berberine compounds (BC), consisting of berberine (BBR), oryzanol and vitamin B6, have been used to treat diabetes and hyperlipidemia in recent years, but the potential mechanisms under the effects have not been well determined.…