Yanqing Liu
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View article: Correction to “An Antibacterial and Antiadhesion <i>In Situ</i> Forming Hydrogel with Sol–Spray System for Noncompressible Hemostasis”
Correction to “An Antibacterial and Antiadhesion <i>In Situ</i> Forming Hydrogel with Sol–Spray System for Noncompressible Hemostasis” Open
View article: Global burden of esophageal diseases: a comprehensive analysis of disease trends and risk factors from 1990 to 2021
Global burden of esophageal diseases: a comprehensive analysis of disease trends and risk factors from 1990 to 2021 Open
For GERD and EC, the global burden continued to rise and decline from 1990 to 2021, respectively. Developing targeted public health strategies in different countries and regions is crucial for alleviating the global burden of ED.
View article: Flow Mode‐Dependent Regulation of von Willebrand Factor Degradation in Mechanical Circulatory Support
Flow Mode‐Dependent Regulation of von Willebrand Factor Degradation in Mechanical Circulatory Support Open
Background Among patients reliant on continuous‐flow (CF) mechanical circulatory support devices, bleeding is primarily caused by an acquired von Willebrand factor (vWF) deficiency, precipitated by the high shear stress and diminished puls…
View article: Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations
Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations Open
Background and objective Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the hyperproliferation and invasive behavior of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), which contributes to the degrad…
View article: Suppression of SRC protein kinase activity alleviates the severity of aganglionosis by impairing CAV1/FLNA expression
Suppression of SRC protein kinase activity alleviates the severity of aganglionosis by impairing CAV1/FLNA expression Open
Objective Hirschsprung's disease (HSCR) is a rare congenital disorder attributed to the defects of enteric neural crest cells. We aim to identify characteristic phosphorylation proteins and preliminarily explore underlying related action m…
View article: Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease
Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease Open
Background Amyloid-β protein (Aβ) accumulation is a defining characteristic of Alzheimer’s disease (AD), resulting in neurodegeneration and a decline in cognitive function. Given orexin’s well-documented role in enhancing memory and cognit…
View article: Neolignan and 3‐Benzylchroman Derivatives From <i>Celastrus orbiculatus</i> Thunb.
Neolignan and 3‐Benzylchroman Derivatives From <i>Celastrus orbiculatus</i> Thunb. Open
Phytochemical investigation of the ethyl acetate extract of the stems of Celastrus orbiculatus Thunb. led to the isolation of a new neolignan, celastorbiol A ( 1 ), and two new homoisoflavones, celastrones A and B ( 2 and 3 ), along with f…
View article: Retraction Note: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma
Retraction Note: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma Open
View article: Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing
Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing Open
View article: Chemical composition and antioxidant potential of ten ornamental Gesneriaceae taxa
Chemical composition and antioxidant potential of ten ornamental Gesneriaceae taxa Open
View article: Dimethyl Fumarate Inhibits Keratinocyte Hyperproliferation and Ameliorates Psoriasis via Directly Targeting Ribosomal Protein S6 Kinase A1
Dimethyl Fumarate Inhibits Keratinocyte Hyperproliferation and Ameliorates Psoriasis via Directly Targeting Ribosomal Protein S6 Kinase A1 Open
View article: Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment
Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment Open
Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis …
View article: Prediction of Sunspot Activity Based on Differential Evolution Algorithm and BP Neural Network Model
Prediction of Sunspot Activity Based on Differential Evolution Algorithm and BP Neural Network Model Open
In this research report, the prediction method of sunspot activity is deeply discussed, and a variety of statistical and data science models are used to make comprehensive prediction. Research focuses include the start time and duration of…
View article: Precise Acetabular Prosthesis Positioning Using a Novel Robot‐Assisted Total Hip Arthroplasty System: A Multicenter, Randomized Controlled Trial
Precise Acetabular Prosthesis Positioning Using a Novel Robot‐Assisted Total Hip Arthroplasty System: A Multicenter, Randomized Controlled Trial Open
Objective Total hip arthroplasty (THA) is currently one of the most effective treatment methods for end‐stage hip joint disease, and its long‐term effectiveness largely depends on the accurate placement of the acetabular prosthesis. In con…
View article: Efficacy of venoarterial extracorporeal membrane oxygenation with and without intra-aortic balloon pump in adult cardiogenic shock
Efficacy of venoarterial extracorporeal membrane oxygenation with and without intra-aortic balloon pump in adult cardiogenic shock Open
Introduction Intra-aortic balloon pump (IABP) is sometimes coupled with Venoarterial extracorporeal membrane oxygenation (VA-ECMO) to treat patients with cardiogenic shock. In this study, we attempted to evaluate the association of the IAB…
View article: Early Radiographic and Clinical Outcomes of Robotic‐arm‐assisted <scp><i>versus</i></scp> Conventional Total Knee Arthroplasty: A Multicenter Randomized Controlled Trial
Early Radiographic and Clinical Outcomes of Robotic‐arm‐assisted <span><i>versus</i></span> Conventional Total Knee Arthroplasty: A Multicenter Randomized Controlled Trial Open
Objective A robotic system was recently introduced to improve prosthetic alignment during total knee arthroplasty (TKA). The purpose of this multicenter, prospective, randomized controlled trial (RCT) was to determine whether robotic‐arm‐a…
View article: Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro
Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro Open
Chronic recurrent itch and skin inflammation are prominent features of atopic dermatitis (AD), which is closely related to the immune response driven by T-helper type 2 (Th2) cells. The expression of interleukin 31 (IL-31) is positively co…
View article: COE targets EphA2 to inhibit vasculogenic mimicry formation induced by hypoxia in hepatocellular carcinoma
COE targets EphA2 to inhibit vasculogenic mimicry formation induced by hypoxia in hepatocellular carcinoma Open
Background Vasculogenic Mimicry (VM) can reduce the efficacy of anti-angiogenesis and promote distant metastasis in hepatocellular carcinoma (HCC). Our previous studies have found that Celastrus orbiculatus extract (COE) can inhibit the VM…
View article: Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4 Open
Adjuvant chemoradiotherapy, molecular targeted therapy, and immunotherapy are frequently employed to extend the survival of patients with advanced gastric cancer (GC). However, most of these treatments have toxic side effects, drug resista…
View article: Alpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification
Alpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification Open
Lung cancer is the most common oncological disease worldwide, with non-small cell lung cancer accounting for approximately 85% of lung cancer cases. α-Hederin is a monodesmosidic triterpenoid saponin isolated from the leaves of Hedera heli…
View article: Advancing crush syndrome management: the potent role of Sodium zirconium cyclosilicate in early hyperkalemia intervention and survival enhancement in a rat model
Advancing crush syndrome management: the potent role of Sodium zirconium cyclosilicate in early hyperkalemia intervention and survival enhancement in a rat model Open
Background: Crush Syndrome (CS), a severe trauma resulting from prolonged muscle compression, is commonly seen in large-scale disasters such as earthquakes. It not only causes localized tissue damage but also triggers electrolyte imbalance…
View article: Effect of Celastrus Orbiculatus Extract on proliferation and apoptosis of human Burkitt lymphoma cells
Effect of Celastrus Orbiculatus Extract on proliferation and apoptosis of human Burkitt lymphoma cells Open
The lymphoma incidence rate is on the rise, with invasive forms particularly prone to relapse following conventional treatment, posing a significant threat to human life and wellbeing. Numerous studies have shown that traditional Chinese b…
View article: Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2
Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2 Open
Objective: Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb, Tripterygium wilfordii . This study aims to provide a scientific basis for the rational development and use of celastrol in breast ca…
View article: <i>Celastrus orbiculatus</i> extract reverses precancerous lesions of gastric cancer by inhibiting autophagy via regulating the PDCD4-ATG5 signaling pathway
<i>Celastrus orbiculatus</i> extract reverses precancerous lesions of gastric cancer by inhibiting autophagy via regulating the PDCD4-ATG5 signaling pathway Open
Objectives Celastrus orbiculatus ethyl acetate extract (COE) is the main extract of the stem of the Chinese herbal C. orbiculatus, which has anti-tumor and anti-inflammatory biological effects. Our previous study showed that COE had a cert…
View article: Prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with chronic heart failure across the different ejection fraction spectrum
Prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with chronic heart failure across the different ejection fraction spectrum Open
The ratio of fibrinogen to albumin (FAR) is considered a new inflammatory biomarker and a predictor of cardiovascular disease risk. However, its prognostic value for patients with chronic heart failure (CHF) with different ejection fractio…
View article: Jianpi Fuzheng Decoction in the Treatment of Gastric Cancer-Related Fatigue
Jianpi Fuzheng Decoction in the Treatment of Gastric Cancer-Related Fatigue Open
Objective: To observe the clinical effects of Jianpi Fuzheng Decoction in patients with gastric cancer and cancer-related fatigue (CRF). Methods: Using the random number table method as a reference, 68 cases of gastric CRF were randomly di…
View article: Alpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification
Alpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification Open
Lung cancer is the most common oncological disease worldwide, with non-small cell lung cancer accounting for approximately 85% of lung cancer cases. α-Hederin is a monodesmosidic triterpenoid saponin isolated from the leaves of Hedera heli…
View article: Effects of 60 Degrees of Flexion and Perioperative Use of Tranexamic Acid on Recovery After Knee Replacement
Effects of 60 Degrees of Flexion and Perioperative Use of Tranexamic Acid on Recovery After Knee Replacement Open
Objective To explore the effect of 60 knee flexion combined with multiple tranexamic acid application on postoperative recovery of knee replacement patients. Methods Knee replacement patients admitted to our hospital from February 2022 to …
View article: Network pharmacology‑based investigation of potential targets of triptonodiol acting on non-small-cell lung cancer
Network pharmacology‑based investigation of potential targets of triptonodiol acting on non-small-cell lung cancer Open
Background Triptonodiol is a very promising antitumor drug candidate extracted from the Chinese herbal remedy Tripterygium wilfordii Hook. F., and related studies are underway. Methods To explore the mechanism of triptonodiol for lung canc…
View article: Traditional Banxia Xiexin decoction inhibits invasion, metastasis, and epithelial mesenchymal transition in gastric cancer by reducing lncRNA TUC338 expression
Traditional Banxia Xiexin decoction inhibits invasion, metastasis, and epithelial mesenchymal transition in gastric cancer by reducing lncRNA TUC338 expression Open