Yanran He
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View article: Association between the age-adjusted visceral adiposity index (AVAI) and gynecologic malignancies: a cross-sectional study based on NHANES data
Association between the age-adjusted visceral adiposity index (AVAI) and gynecologic malignancies: a cross-sectional study based on NHANES data Open
The AVAI, a composite index that integrates visceral fat distribution and metabolic function, was shown for the first time to be significantly associated with the risk of gynecologic malignancies, particularly cervical cancer, for which it…
POS-069 TIME-DEPENDENT PROTEOMICS PROFILE AFTER RENAL ISCHEMIA-REPERFUSION INJURY Open
Renal Ischemia-reperfusion (IR) is one of the most common causes for acute kidney injury (AKI). We investigated the time-dependent protein expression changes in renal IR injury using quantitative proteomics.
Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides Open
Significance CAR T cells have shown significant promise in treating hematopoietic cancers but challenges remain, including antigen loss and identification of targets in solid tumors. Aberrant O-linked glycosylation in solid cancers is comm…
Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell Open
Human cancer cells were eradicated by adoptive transfer of T cells transduced with a chimeric antigen receptor (CAR) made from an antibody (237Ab) that is highly specific for the murine Tn-glycosylated podoplanin (Tn-PDPN). The objectives …
Multiple cancer-specific antigens are targeted by a chimeric antibody receptor on a single cancer cell Open
Human cancer cells were eradicated by adoptive transfer of T cells transduced with a chimeric antigen receptor (CAR) made from an antibody (237Ab) that is highly specific for the murine Tn-glycosylated podoplanin (Tn-PDPN). The objectives …
View article: TCR–pMHC bond conformation controls TCR ligand discrimination
TCR–pMHC bond conformation controls TCR ligand discrimination Open
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds an…
Simultaneous Targeting of Multiple Cancer-Specific Antigens on a Cancer Cell by One Chimeric Antigen Receptor Open
Two key challenges for chimeric antibody receptor (CAR) T cell therapies for cancers are: The toxicities from targeting non-cancer-specific antigens. And the relapses from antigen-loss-variants (ALVs). In this study, we have shown that a C…