Yun Lu
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Author Swipe
View article: Association between immune check point inhibitors and digestive system inflammatory adverse reactions: evidence from pharmacovigilance analysis and systematic review
Association between immune check point inhibitors and digestive system inflammatory adverse reactions: evidence from pharmacovigilance analysis and systematic review Open
Purpose Comparative real-world data on the spectrum of digestive inflammatory adverse reactions across ICI classes are limited. Existing evidence on immune-related Sjögren’s syndrome/sialadenitis consists largely of case reports and small …
View article: Safety of antidepressants commonly used in 6–17-year-old children and adolescents: A disproportionality analysis from 2014–2023 on the basis of the FAERS database
Safety of antidepressants commonly used in 6–17-year-old children and adolescents: A disproportionality analysis from 2014–2023 on the basis of the FAERS database Open
Background Depression is a common mental disorder in children and adolescents, and antidepressants are widely used for treatment. This study aimed to explore and analyze adverse events (AEs) associated with antidepressant use in this popul…
View article: Hepatotoxicity associated with statins: A retrospective pharmacovigilance study based on the FAERS database
Hepatotoxicity associated with statins: A retrospective pharmacovigilance study based on the FAERS database Open
Background Statins are commonly prescribed in clinical practice and are associated with a high risk of drug-induced liver injury (DILI). This study aims to examine the real-world data on statin-induced liver injury to assess medication saf…
View article: Different Performance of Transformer and Logistic Regression Models in Credit Risk Prediction
Different Performance of Transformer and Logistic Regression Models in Credit Risk Prediction Open
Nowadays, people’s use of credit cards is increasing significantly, and the importance of predicting credit default for banks has become higher. This paper aims to compare the different performances of two binary classification methods--lo…
View article: Modernizing Research and Evidence Consensus Definitions
Modernizing Research and Evidence Consensus Definitions Open
Importance The US Food and Drug Administration (FDA) and National Institutes of Health (NIH) share a mutual interest in facilitating efficient, well-designed clinical studies of drugs, devices, and biological products. Recent advances in s…
View article: Association of radiotherapy with secondary pelvic cancers in male patients with rectal cancer
Association of radiotherapy with secondary pelvic cancers in male patients with rectal cancer Open
Male rectal cancer patients receiving RT had a decreased risk of SPC and an increased risk of SBC, and the prognosis of SPC patients in the RT group was worse compared to that of the NRT group. Follow-up and monitoring of SBC and SPC shoul…
View article: Different Performance of Transformer and Logistic Regression Models in Credit Risk Prediction
Different Performance of Transformer and Logistic Regression Models in Credit Risk Prediction Open
Nowadays, people’s use of credit cards is increasing significantly, and the importance of predicting credit default for banks has become higher. This paper aims to compare the different performances of two binary classification methods--lo…
View article: Lessons Learned From Characterizing Long <scp>COVID</scp> Among US Medicare Beneficiaries
Lessons Learned From Characterizing Long <span>COVID</span> Among US Medicare Beneficiaries Open
Purpose To characterize long‐term effects of COVID‐19 among older adults (aged ≥ 65 years). Methods This retrospective descriptive study utilized Medicare Fee‐for‐Service beneficiaries' claims to characterize post‐COVID condition diagnosis…
View article: A surrogate endpoint-based provisional approval causal roadmap, illustrated by vaccine development
A surrogate endpoint-based provisional approval causal roadmap, illustrated by vaccine development Open
Summary For many rare diseases with no approved preventive interventions, promising interventions exist. However, it has proven difficult to conduct a pivotal phase 3 trial that could provide direct evidence demonstrating a beneficial effe…
View article: ResNet-Vision Transformer based MRI-endoscopy fusion model for predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A multicenter study
ResNet-Vision Transformer based MRI-endoscopy fusion model for predicting treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A multicenter study Open
Background: Neoadjuvant chemoradiotherapy followed by radical surgery has been a common practice for patients with locally advanced rectal cancer, but the response rate varies among patients. This study aimed to develop a ResNet-Vision Tra…
View article: Acute respiratory distress syndrome caused by Chlamydia psittaci: a case report and literature review
Acute respiratory distress syndrome caused by Chlamydia psittaci: a case report and literature review Open
Background Psittacosis is a zoonotic disease with a low incidence rate and a lack of specificity in clinical manifestations, making it prone to be missed, misdiagnosed, and even cause delayed treatment for patients. Metagenomic next-genera…
View article: Relative Effectiveness and Waning of a Third Dose of mRNA COVID-19 Vaccine in Medicare Beneficiaries Aged 65 Years and Older During the BA.1/BA.2 Omicron Period
Relative Effectiveness and Waning of a Third Dose of mRNA COVID-19 Vaccine in Medicare Beneficiaries Aged 65 Years and Older During the BA.1/BA.2 Omicron Period Open
Background We assessed the added benefit and waning effectiveness of a third COVID-19 vaccine dose (original formula) for preventing COVID-19–related outcomes. Methods We used Medicare claims data to conduct a retrospective cohort study in…
View article: Use of proton pump inhibitors and risk of severe COVID‐19: A case–control study in United States Medicare beneficiaries
Use of proton pump inhibitors and risk of severe COVID‐19: A case–control study in United States Medicare beneficiaries Open
Background Concerns have been raised regarding proton pump inhibitor (PPI) use and risk of severe coronavirus disease 2019 (COVID‐19). Observational studies have yielded heterogeneous results and were subject to important methodological li…
View article: Establishment of an HPLC Fingerprint and Cluster Analysis for Miao Ethnic Medicine Osbeckia opipara
Establishment of an HPLC Fingerprint and Cluster Analysis for Miao Ethnic Medicine Osbeckia opipara Open
: Osbeckia opipara, a traditional Miao medicine, is commonly used by the renowned national-level Chinese Traditional Medicine practitioner Zhengshi Wu for the treatment of diarrhea due to its strong antioxidative, anti-inflammatory, and an…
View article: Stroke After Influenza Vaccines in Older Adults in the US, 2016 to 2019
Stroke After Influenza Vaccines in Older Adults in the US, 2016 to 2019 Open
This case series investigates whether an increase in stroke risk occurred after influenza vaccination among fee-for-service Medicare beneficiaries during the influenza seasons from 2016 to 2019.
View article: Antibiotic-induced severe cutaneous adverse reactions: a single-center retrospective study over ten years
Antibiotic-induced severe cutaneous adverse reactions: a single-center retrospective study over ten years Open
Objective Severe cutaneous adverse reactions (SCARs) are rare but life-threatening, with antibiotics being the main cause. This retrospective study from a single center was designed to analyze the culprit drugs, clinical features and treat…
View article: Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study
Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study Open
Purpose Neoadjuvant chemoradiotherapy has been the standard practice for patients with locally advanced rectal cancer. However, the treatment response varies greatly among individuals, how to select the optimal candidates for neoadjuvant c…
View article: Stroke Risk After COVID-19 Bivalent Vaccination Among US Older Adults
Stroke Risk After COVID-19 Bivalent Vaccination Among US Older Adults Open
Importance In January 2023, the US Centers for Disease Control and Prevention and the US Food and Drug Administration noted a safety concern for ischemic stroke among adults aged 65 years or older who received the Pfizer-BioNTech BNT162b2;…
View article: Real-world Effectiveness of mRNA COVID-19 Vaccines Among US Nursing Home Residents Aged ≥65 Years in the Pre-Delta and High Delta Periods
Real-world Effectiveness of mRNA COVID-19 Vaccines Among US Nursing Home Residents Aged ≥65 Years in the Pre-Delta and High Delta Periods Open
Background Long-term care residents were among the most vulnerable during the COVID-19 pandemic. We estimated vaccine effectiveness of mRNA COVID-19 vaccines in Medicare nursing home residents aged ≥65 years during pre-Delta and high Delta…
View article: Identification and validation of pyroptosis-related genes as potential biomarkers for hypertrophic cardiomyopathy: A comprehensive bioinformatics analysis
Identification and validation of pyroptosis-related genes as potential biomarkers for hypertrophic cardiomyopathy: A comprehensive bioinformatics analysis Open
Pyroptosis plays a key role in the death of cells including cardiomyocytes, and it is associated with a variety of cardiovascular diseases. However, the role of pyroptosis-related genes (PRGs) in hypertrophic cardiomyopathy (HCM) is not we…
View article: Cutting-edge research on the action plan for the prevention and control of emerging contaminants in China
Cutting-edge research on the action plan for the prevention and control of emerging contaminants in China Open
Editorial: cutting-edge research on the action plan for the prevention and control of emerging contaminants in ChinaWater treatment and reuse is the key strategy to address the problems of water shortages.To facilitate the communication an…
View article: Transarterial chemoembolization with insertion of radioactive seeds for hepatocellular carcinoma.
Transarterial chemoembolization with insertion of radioactive seeds for hepatocellular carcinoma. Open
These data suggest that a combination of TACE and RSI can contribute to significant improvements in HCC patient therapeutic response rates, OS, and PFS relative to TACE alone.
View article: <scp>HIV</scp> risk behavior profiles among men who have sex with men interested in donating blood: Findings from the Assessing Donor Variability and New Concepts in Eligibility study
<span>HIV</span> risk behavior profiles among men who have sex with men interested in donating blood: Findings from the Assessing Donor Variability and New Concepts in Eligibility study Open
Background Individual risk assessment allows donors to be evaluated based on their own behaviors. Study objectives were to assess human immunodeficiency virus (HIV) risk behaviors in men who have sex with men (MSM) and estimate the proport…
View article: HIV Risk Behavior Profiles Among Men Who Have Sex with Men Interested in Donating Blood: The Assessing Donor Variability and New Concepts in Eligibility (ADVANCE) Study
HIV Risk Behavior Profiles Among Men Who Have Sex with Men Interested in Donating Blood: The Assessing Donor Variability and New Concepts in Eligibility (ADVANCE) Study Open
Importance Blood donor selection policies should be evidence-based. Individual risk assessment allows potential donors to be evaluated based on their own behaviors. Objective The Assessing Donor Variability and New Concepts in Eligibility …
View article: Evaluation of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Adults Aged 65 Years and Older: A Self-Controlled Study in the U.S
Evaluation of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Adults Aged 65 Years and Older: A Self-Controlled Study in the U.S Open
Background Our near-real-time safety monitoring of 16 adverse events (AEs) following COVID-19 mRNA vaccination identified potential elevations in risk for six AEs following primary series and monovalent booster dose administration. The cru…