Yu Gu
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View article: Clinical Research Progress of Perioperative Hidden Blood Loss in Elderly Patients with Femoral Intertrochanteric Fractures
Clinical Research Progress of Perioperative Hidden Blood Loss in Elderly Patients with Femoral Intertrochanteric Fractures Open
Intertrochanteric fracture of femur is a common type of fracture in elderly patients with osteoporosis. At present, this fracture is mainly treated by surgery. With the advancement of medical technology, trochanteric fracture can be comple…
View article: Effect of remimazolam besylate versus propofol on haemodynamic profiles in patients undergoing thyroid surgery with recurrent laryngeal nerve monitoring: a protocol for a randomised controlled trial
Effect of remimazolam besylate versus propofol on haemodynamic profiles in patients undergoing thyroid surgery with recurrent laryngeal nerve monitoring: a protocol for a randomised controlled trial Open
Introduction Thyroid surgery with intraoperative nerve monitoring under total intravenous anaesthesia often requires deeper sedation due to limitations or lack of neuromuscular blocking agents, usually resulting in haemodynamic instability…
View article: A population study comparing tracheal and lung adenoid cystic carcinoma
A population study comparing tracheal and lung adenoid cystic carcinoma Open
Background Thoracic adenoid cystic carcinoma (ACC) is rare, and the differences between tracheal and lung lesions have not been fully understood. Methods Patients were identified from a Chinese cancer center (FUSCC) (2005–2022) and the Sur…
View article: Comparison of treatment strategies for resectable locally advanced primary mucinous adenocarcinoma of the lung
Comparison of treatment strategies for resectable locally advanced primary mucinous adenocarcinoma of the lung Open
Background Primary pure mucinous adenocarcinoma (PMA) is a rare type of lung cancer with unique clinical and prognostic features. Previous studies have shown that PMA have more early‐stage cancer compared with other adenocarcinoma (ADC) su…
View article: Effects of subanaesthetic S-ketamine on postoperative delirium and cognitive function in elderly patients undergoing non-cardiac thoracic surgery: a protocol for a randomised, double-blinded, placebo-controlled and positive-controlled, non-inferiority trial (SKED trial)
Effects of subanaesthetic S-ketamine on postoperative delirium and cognitive function in elderly patients undergoing non-cardiac thoracic surgery: a protocol for a randomised, double-blinded, placebo-controlled and positive-controlled, non-inferiority trial (SKED trial) Open
Introduction Postoperative delirium (POD) is a common and distressing complication after thoracic surgery. S-ketamine has neuroprotective properties as a dissociative anaesthetic. Emerging literature has indicated that S-ketamine can reduc…
View article: DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis Open
Background Previously, we reported the expression of DLX4 isoforms ( BP1 and DLX7 ) in myeloid leukemia, but the functional role of DLX4 isoforms remains poorly understood. In the work described herein, we further determined the underlying…
View article: Whole-Genome DNA Methylation Sequencing Reveals Epigenetic Changes in Myelodysplastic Syndromes
Whole-Genome DNA Methylation Sequencing Reveals Epigenetic Changes in Myelodysplastic Syndromes Open
Epigenetic dysregulation of cancer-associated genes has been identified to contribute to the pathogenesis of myelodysplastic syndromes (MDS). However, few studies have elucidated the whole-genome DNA methylation in the initiation pathogene…
View article: Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia
Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia Open
Leukocyte immunoglobulin (Ig)-like receptor Bs (LILRBs), a family of type I transmembrane glycoproteins, are known to inhibit immune activation. Here, we comprehensively evaluated the molecular, prognostic, and immunological charact…
View article: Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial
Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial Open
View article: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia
Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia Open
Background Obesity confers enhanced risk for multiple diseases including cancer. The DNA methylation alterations in obesity-related genes have been implicated in several human solid tumors. However, the underlying role and clinical implica…
View article: [Effects of different postoperative analgesic strategies on postoperative neurocognitive function and quality of recovery in elderly patients undergoing one lung ventilation].
[Effects of different postoperative analgesic strategies on postoperative neurocognitive function and quality of recovery in elderly patients undergoing one lung ventilation]. Open
In elderly patients undergoing surgeries with one lung ventilation, general anesthesia combined with either postoperative continuous thoracic paravertebral block or epidural analgesia can significantly improve postoperative neurocognitive …
View article: AZD9291 Resistance Reversal Activity of a pH‐Sensitive Nanocarrier Dual‐Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC
AZD9291 Resistance Reversal Activity of a pH‐Sensitive Nanocarrier Dual‐Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC Open
AZD9291 can effectively prolong survival of non‐small cell lung cancer (NSCLC) patients. Unfortunately, the mechanism of its acquired drug resistance is largely unknown. This study shows that autophagy and fibroblast growth factor receptor…
View article: Giant axillary tumor resection using ultrasound-guided interscalene brachial plexus block and serratus anterior plane block
Giant axillary tumor resection using ultrasound-guided interscalene brachial plexus block and serratus anterior plane block Open
Herein, we report the combined use of interscalene brachial plexus block and serratus anterior plane block for surgical removal of a large neoplasm that was embedded deep in the axilla and chest wall of a patient with high-risk hypertensio…
View article: The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome
The Potential Role of Gut Mycobiome in Irritable Bowel Syndrome Open
The human gut is inhabited by diverse microorganisms that play crucial roles in health and disease. Gut microbiota dysbiosis is increasingly considered as a vital factor in the etiopathogenesis of irritable bowel syndrome (IBS), which is a…
View article: Comprehensive analysis of circular RNA profiling in AZD9291‐resistant non‐small cell lung cancer cell lines
Comprehensive analysis of circular RNA profiling in AZD9291‐resistant non‐small cell lung cancer cell lines Open
Background Osimertinib (AZD9291), a third‐generation EGFR‐tyrosine kinase inhibitor, can effectively prolong survival in non‐small cell lung cancer (NSCLC) patients with EGFR mutations, particularly T790M mutations; however, acquired resis…
View article: Should minimally invasive lung adenocarcinoma be transferred from stage IA1 to stage 0 in future updates of the TNM staging system?
Should minimally invasive lung adenocarcinoma be transferred from stage IA1 to stage 0 in future updates of the TNM staging system? Open
Patients with AIS and MIA had similar post-surgical survival rates. We propose that MIA may potentially be transferred from IA1 to stage 0 in the future.
View article: Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity‐matched study based on the SEER database
Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity‐matched study based on the SEER database Open
Background The prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database. Methods This retrospective study used SEER data of TNET patients betwe…
View article: Prognosis of limited resection versus lobectomy in elderly patients with invasive lung adenocarcinoma with tumor size less than or equal to 2 cm
Prognosis of limited resection versus lobectomy in elderly patients with invasive lung adenocarcinoma with tumor size less than or equal to 2 cm Open
We conclude that wedge resection may be a reasonable surgical choice for elderly patients with tumor sizes ≤1 cm.
View article: Visceral pleural invasion predict a poor survival among lung adenocarcinoma patients with tumor size ≤ 3cm
Visceral pleural invasion predict a poor survival among lung adenocarcinoma patients with tumor size ≤ 3cm Open
VPI could predict a poor survival even for node-negative invasive lung adenocarcinoma patients with tumor size less than 3cm.
View article: Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer
Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer Open
Tamoxifen(TAM) is one of the most effective endocrine treatment for estrogen receptor(ER)-positive breast cancer, however drug resistance greatly limits benefit of it. Our purpose is to uncover the role of Beclin 1 in tamoxifen resistance …