Yanshu Zhang
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View article: Hypertension aggravates lead exposure induced microglia polarization via ANT1 regulating mtDNA leakage
Hypertension aggravates lead exposure induced microglia polarization via ANT1 regulating mtDNA leakage Open
View article: Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis
Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis Open
Environmental lead (Pb) exposure has been implicated in the development of depression. Here we show that Pb induces depression-like behaviour in mice by triggering ferroptosis. Single-cell RNA sequencing revealed that astrocytes exhibited …
View article: Magnetic beads‐based ligand fishing for rapid screening of dietary α‐glucosidase inhibitory ligands from the rhizome of <scp><i>Alpinia officinarum</i></scp> Hance combined with molecular docking
Magnetic beads‐based ligand fishing for rapid screening of dietary α‐glucosidase inhibitory ligands from the rhizome of <span><i>Alpinia officinarum</i></span> Hance combined with molecular docking Open
BACKGROUND The rhizome of Alpinia officinarum Hance, considered as a medicinal and edible plant, is gathering increasing attention as a natural source for exploring dietary α‐glucosidase inhibitors. Magnetic beads‐based ligand fishing has …
View article: The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering
The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering Open
View article: Point Cloud Neural Operator for Parametric PDEs on Complex and Variable Geometries
Point Cloud Neural Operator for Parametric PDEs on Complex and Variable Geometries Open
Surrogate models are critical for accelerating computationally expensive simulations in science and engineering, particularly for solving parametric partial differential equations (PDEs). Developing practical surrogate models poses signifi…
View article: A near-complete genome assembly of the bearded dragon <i>Pogona vitticeps</i> provides insights into the origin of <i>Pogona</i> sex chromosomes
A near-complete genome assembly of the bearded dragon <i>Pogona vitticeps</i> provides insights into the origin of <i>Pogona</i> sex chromosomes Open
Background Vertebrate sex is typically determined either by genetic factors, such as sex chromosomes, or by environmental cues like temperature. Therefore, the agamid dragon lizard Pogona vitticeps is remarkable in this regard, as it exhib…
View article: Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure
Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure Open
Periodontal regenerative medicine is currently undergoing a paradigm shift from dissecting the healing process toward utilization of the developmental program. Biological hydroxyapatite (BHA), a major component of guided tissue regeneratio…
View article: Point Cloud Neural Operator for Parametric Pdes on Complex and Variable Geometries
Point Cloud Neural Operator for Parametric Pdes on Complex and Variable Geometries Open
View article: Comprehensive analysis of clinical research profiles and study characteristics of oral potentially malignant disorders: an observational study
Comprehensive analysis of clinical research profiles and study characteristics of oral potentially malignant disorders: an observational study Open
View article: Identification of DREB Family Genes in Banana and Their Function under Drought and Cold Stress
Identification of DREB Family Genes in Banana and Their Function under Drought and Cold Stress Open
Bananas are one of the most important cash crops in the tropics and subtropics. Drought and low-temperature stress affect the growth of banana. The DREB (dehydration responsive element binding protein) gene family, as one of the major tran…
View article: The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine
The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine Open
View article: Identification of Dreb Family Genes in Banana and the Functional Under Drought and Cold Stress
Identification of Dreb Family Genes in Banana and the Functional Under Drought and Cold Stress Open
View article: Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment
Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment Open
The results of this study could provide some favorable theoretical bases for applying periodontal development engineering strategy in resolving the difficulties in periodontal multi-tissue regeneration.
View article: PAPR: Proximity Attention Point Rendering
PAPR: Proximity Attention Point Rendering Open
Learning accurate and parsimonious point cloud representations of scene surfaces from scratch remains a challenge in 3D representation learning. Existing point-based methods often suffer from the vanishing gradient problem or require a lar…
View article: Identification of the passion fruit (Passiflora edulis Sims) MYB family in fruit development and abiotic stress, and functional analysis of PeMYB87 in abiotic stresses
Identification of the passion fruit (Passiflora edulis Sims) MYB family in fruit development and abiotic stress, and functional analysis of PeMYB87 in abiotic stresses Open
Environmental stresses are ubiquitous in agricultural cultivation, and they affect the healthy growth and development of edible tissues in passion fruit. The study of resistance mechanisms is important in understanding the adaptation and r…
View article: PbO Nanoparticles Increase the Expression of ICAM-1 and VCAM-1 by Increasing Reactive Oxygen Species Production in Rat Choroidal Epithelial Line Z310 Cells
PbO Nanoparticles Increase the Expression of ICAM-1 and VCAM-1 by Increasing Reactive Oxygen Species Production in Rat Choroidal Epithelial Line Z310 Cells Open
PbO nanoparticles (nano-PbO) are widely used in the production of electrode materials, but exposure to them can cause brain damage. The first barrier preventing nano-PbO from entering the brain is the choroid plexus. However, the effect of…
View article: Genome-wide alternation and effect of DNA methylation in the impairments of steroidogenesis and spermatogenesis after PM2.5 exposure
Genome-wide alternation and effect of DNA methylation in the impairments of steroidogenesis and spermatogenesis after PM2.5 exposure Open
The effects of ambient fine particles on male reproductive health have raised widespread concern. The particular underlying mechanisms of the damage remain largely unclear and demand more research in new directions. Previous research has r…
View article: TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma Open
Characterization of the dynamic change in the immunological landscape during malignant transformation from precancerous lesions to cancerous lesions in squamous cell carcinoma (SCC) is critical for the application of immunotherapy. Here, w…
View article: Associations of mixed metals exposure with risk of cognitive impairment: A cross-sectional study in Chinese adults
Associations of mixed metals exposure with risk of cognitive impairment: A cross-sectional study in Chinese adults Open
Background Associations between exposure to single metals and cognitive impairment or related outcomes have been reported in many previous studies. However, co-exposure to more than one metal is common situation. In recent years, studies o…
View article: Potential significance of Nrf2-ROS-MMP-9 axis in blood cerebrospinal fluid barrier dysfunction induced by lanthanum chloride
Potential significance of Nrf2-ROS-MMP-9 axis in blood cerebrospinal fluid barrier dysfunction induced by lanthanum chloride Open
Lanthanum (La) can cause brain barrier injured and lead to the cognitive impairment. Yet, fewer research about La induced the blood cerebrospinal fluid barrier (BCSFB) dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a ke…
View article: MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure
MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure Open
An increasing number of studies have clarified that ferroptosis plays a vital role in neurodegenerative diseases, which is characterized by the accumulation of Fe2+, lipid peroxidation, and alteration of mitochondrial structure.…
View article: Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1
Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1 Open
View article: Genome-Wide Profiling Identifies Testicular DNA Methylation Involved in Real-World Pm2.5-Induced Impairment of Steroidogenesis and Spermatogenesis in Mice
Genome-Wide Profiling Identifies Testicular DNA Methylation Involved in Real-World Pm2.5-Induced Impairment of Steroidogenesis and Spermatogenesis in Mice Open
View article: Research progress on the MYB transcription factors in tropical fruit
Research progress on the MYB transcription factors in tropical fruit Open
Tropical fruits, such as bananas, passion fruit, mangoes, and lychees, are rich in vitamins, flavonoids and non-flavonoid phenols, and are the healthiest way to intake bioactive compounds in one's daily diet. Coupled with their unique tast…
View article: Role of Nf-Κb in Activation of Astrocytes Induced by Lead Exposure Based on Bioinformatics Analysis of Hippocampal Proteomics
Role of Nf-Κb in Activation of Astrocytes Induced by Lead Exposure Based on Bioinformatics Analysis of Hippocampal Proteomics Open
View article: Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier
Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier Open
View article: Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway
Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway Open
High malignancy and high mortality of glioma render it urgent to elucidate the underlying mechanisms of glioma carcinogenesis and explore novel targets for therapy. Epidemiologic and clinical studies have revealed that chronic stress promo…
View article: A cross–sectional survey of preschool children: Exploring heavy metal exposure, neurotransmitters, and neurobehavioural relationships and mediation effects
A cross–sectional survey of preschool children: Exploring heavy metal exposure, neurotransmitters, and neurobehavioural relationships and mediation effects Open
View article: Research on Early Warning Mechanism and Model of Liver Cancer Rehabilitation Based on CS-SVM
Research on Early Warning Mechanism and Model of Liver Cancer Rehabilitation Based on CS-SVM Open
Since the 20th century, cancer has become one of the main diseases threatening human health. Liver cancer is a malignant tumor with extremely high clinical morbidity and fatality rate and easy recurrence after surgery. Research on the post…
View article: Correction to: The Role of Nrf2 on the Cognitive Dysfunction of High-fat Diet Mice Following Lead Exposure
Correction to: The Role of Nrf2 on the Cognitive Dysfunction of High-fat Diet Mice Following Lead Exposure Open