Yanting Wu
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View article: Association between lower fasting plasma glucose levels during oral glucose tolerance test and adverse perinatal outcomes: A Chinese cohort study
Association between lower fasting plasma glucose levels during oral glucose tolerance test and adverse perinatal outcomes: A Chinese cohort study Open
Background It is unknown whether fasting plasma glucose (FPG) level within the normal range as defined by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is associated with perinatal outcomes. This st…
View article: Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications
Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications Open
Exosomes, nanoscale vesicles secreted by diverse cell types, serve as critical mediators of intercellular and interorgan communication in metabolic physiology. Their unique advantages include encapsulating cell‐specific biomolecules that r…
View article: Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome
Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome Open
Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains un…
View article: A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention
A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention Open
This paper describes the methods for the development and implementation of the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI) intervention, part of a World Health Organization-supported effort to prevent childhood obesity thr…
View article: A mitochondrial regulator protein, mitofusin 2, is elevated in the maternal blood of women with preeclampsia
A mitochondrial regulator protein, mitofusin 2, is elevated in the maternal blood of women with preeclampsia Open
In early-onset placenta, the expression of Mfn2 is significantly lower than that in full-term pregnancy, while in late-onset eclampsia, it is not, indicating that the abnormal expression of Mnf2 in placenta is related to the occurrence per…
View article: An ultraconserved pseudo 5' splice site fine-tunes development by regulating alternative splicing within TOR-related pathways
An ultraconserved pseudo 5' splice site fine-tunes development by regulating alternative splicing within TOR-related pathways Open
Introns have expanded dramatically during evolution, in which ultraconserved RNA motifs may play essential regulatory roles. Sharing the sequence with the actual 5' splice sites (5'SSs), pseudo-5'SSs are widespread in introns but never spl…
View article: A meta‐analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus
A meta‐analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus Open
This study aims to comprehensively evaluate the association between gestational diabetes mellitus (GDM) and the risk of chronic diseases, including obesity, glycolipid metabolic disorders, neurodevelopmental conditions and cardiovascular d…
View article: Optimal Gestational Weight Gain and Fetal Growth in Urban Environments: The Role of Residential Greenness
Optimal Gestational Weight Gain and Fetal Growth in Urban Environments: The Role of Residential Greenness Open
The influence of residential greenness on maternal gestational weight gain (GWG) and fetal intrauterine growth remains understudied. This study examined the impact of residential greenness on GWG and fetal intrauterine growth and assessed …
View article: Internet-Based Cognitive Behavioral Therapy for Preventing Postpartum Depressive Symptoms Among Pregnant Individuals With Depression: Multicenter Randomized Controlled Trial in China
Internet-Based Cognitive Behavioral Therapy for Preventing Postpartum Depressive Symptoms Among Pregnant Individuals With Depression: Multicenter Randomized Controlled Trial in China Open
Background Women are particularly vulnerable to depression during pregnancy, which is one of the strongest risk factors for developing postpartum depression (PPD). Addressing antenatal depressive symptoms in these women is crucial for prev…
View article: Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy
Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy Open
Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM2.5 and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different co…
View article: Ultrasensitive simultaneous detection of lead and cadmium in water using gold nanocluster-modified gold electrodes
Ultrasensitive simultaneous detection of lead and cadmium in water using gold nanocluster-modified gold electrodes Open
Novel GNPs-Au modified electrode enables ultrasensitive detection of Pb 2+ and Cd 2+ (1 ng L −1 LOD) with 7.2-fold enhanced sensitivity. Achieves 90–113% recovery in real water samples. Ideal for environmental monitoring applications.
View article: Associations of Education Attainment With Postpartum Depression and the Mediating Exploration: A Mendelian Randomization Study
Associations of Education Attainment With Postpartum Depression and the Mediating Exploration: A Mendelian Randomization Study Open
Background: Many studies have explored the relationship between education and postpartum depression (PPD), with inconsistent results. Our study is to identify which education‐related factors (education attainment, qualifications, cognitive…
View article: A spatiotemporal transcriptomic atlas of mouse placentation
A spatiotemporal transcriptomic atlas of mouse placentation Open
The placenta, a temporary but essential organ for gestational support, undergoes intricate morphological and functional transformations throughout gestation. However, the spatiotemporal patterns of gene expression underlying placentation r…
View article: High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring
High Estradiol Environment After IVF Causes Increased Risk of Glucose Metabolic Dysfunction in Offspring Open
Context Assisted reproductive technology (ART) is associated with increased metabolic risks in offspring. The effect of high maternal estradiol (E2) levels during early pregnancy on the glucose metabolism of offspring remains unclear. Obje…
View article: Serpina3c deficiency aggravates vascular dysfunction and VSMC dysregulation through regulating adamts4 pathway activity in obese mice
Serpina3c deficiency aggravates vascular dysfunction and VSMC dysregulation through regulating adamts4 pathway activity in obese mice Open
Background Obesity leads to arterial stiffness (AS), which is an independent risk factor for cardiovascular disease. Vascular smooth muscle cell (VSMC) dysfunction is a critical step in the development of AS. Adamts4 (a disintegrin and met…
View article: Single-cell RNA-sequencing analysis of the effects of frozen-thawed embryo transfer on the transcriptome of trophoblasts
Single-cell RNA-sequencing analysis of the effects of frozen-thawed embryo transfer on the transcriptome of trophoblasts Open
Objective: Frozen-thawed embryo transfer (FET) is widely used in in vitro fertilization (IVF) clinics but is associated with an increased risk of several pregnancy complications, including large-for-gestational age and placenta-related dis…
View article: Safety of embryo cryopreservation: insights from mid-term placental transcriptional changes
Safety of embryo cryopreservation: insights from mid-term placental transcriptional changes Open
Background In recent years, with benefits from the continuous improvement of clinical technology and the advantage of fertility preservation, the application of embryo cryopreservation has been growing rapidly worldwide. However, amidst th…
View article: Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth
Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth Open
Exposure to certain heavy metals has been demonstrated to be associated with a higher risk of preterm birth (PTB). However, studies focused on the effects of other metal mixtures were limited. A nested case‒control study enrolling 94 PTB c…
View article: Aging‐induced short‐chain acyl‐CoA dehydrogenase promotes age‐related hepatic steatosis by suppressing lipophagy
Aging‐induced short‐chain acyl‐CoA dehydrogenase promotes age‐related hepatic steatosis by suppressing lipophagy Open
Hepatic steatosis, the first step in the development of nonalcoholic fatty liver disease (NAFLD), is frequently observed in the aging population. However, the underlying molecular mechanism remains largely unknown. In this study, we first …
View article: Influence of the number of washings for embryos on non-invasive preimplantation chromosome screening results
Influence of the number of washings for embryos on non-invasive preimplantation chromosome screening results Open
Objective To explore the effect of varying numbers of embryo washings prior to blastocyst formation in non-invasive preimplantation chromosome screening (NICS) on the accuracy of NICS results. Methods In this study, 68 blastocysts from pre…
View article: Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study
Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study Open
Preeclampsia is a primary placental disorder, with impaired placental vascularization leading to uteroplacental hypoperfusion. We aimed to investigate differences in metal and metalloid content between the placentas of women with preeclamp…
View article: Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial
Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial Open
Background Significant lower genital tract (LGT) dysbiosis and an associated lower rate of clinical pregnancy after in vitro fertilization–frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients have been previousl…