Yongcheng Pan
YOU?
Author Swipe
View article: Decreased scleral Wnt5ahi fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice
Decreased scleral Wnt5ahi fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice Open
Myopia is a common refractive error with high prevalence; its pathogenesis is poorly understood. Scleral single-cell RNA sequencing is used to determine whether there is an association between phenotypic heterogeneity of scleral fibroblast…
View article: 神经元核内包涵体病的动物及人源细胞模型构建与机制研究进展
神经元核内包涵体病的动物及人源细胞模型构建与机制研究进展 Open
Neuronal intranuclear inclusion disease (NIID) is a rare autosomal dominant neurodegenerative disorder defined by the presence of eosinophilic intranuclear inclusions across both central and peripheral components of the nervous system, as …
View article: GGC expansions in <i>NOTCH2NLC</i> contribute to Parkinson disease and dopaminergic neuron degeneration
GGC expansions in <i>NOTCH2NLC</i> contribute to Parkinson disease and dopaminergic neuron degeneration Open
Background and purpose The role of GGC repeat expansions within NOTCH2NLC in Parkinson's disease (PD) and the substantia nigra (SN) dopaminergic neuron remains unclear. Here, we profile the NOTCH2NLC GGC repeat expansions in a large cohort…
View article: Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models Open
Background Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by widespread intranuclear inclusions in the nervous system as well as multiple visceral organs. In 2019, expanded GGC repeats wit…
View article: Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model
Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model Open
Introduction Huntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT). Ras homolog enriched in the …
View article: Expression of expanded GGC repeats within <i>NOTCH2NLC</i> causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease
Expression of expanded GGC repeats within <i>NOTCH2NLC</i> causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease Open
GGC repeat expansions within NOTCH2NLC have been identified as the genetic cause of neuronal intranuclear inclusion disease (NIID). To understand the molecular pathogenesis of NIID, here, we established both a transgenic mouse model and a …
View article: Identification of a Novel Heterozygous Mutation in the EIF2B4 Gene Associated With Vanishing White Matter Disease
Identification of a Novel Heterozygous Mutation in the EIF2B4 Gene Associated With Vanishing White Matter Disease Open
Vanishing white matter disease (VWM) is one of the most common childhood inherited leukoencephalopathies with autosomal recessive inheritance. Mutations in five genes, EIF2B1-5 , have been identified as the major cause of VWM. In this stud…
View article: Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice
Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice Open
Significance A variety of neurodegenerative diseases show selective neuronal loss in distinct brain regions. It remains unclear how the ubiquitously expressed disease proteins can cause selective neurodegeneration. In Huntington’s disease,…
View article: Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response
Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response Open
Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington's disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the …
View article: Phosphorylation of myelin regulatory factor by <scp>PRKG</scp> 2 mediates demyelination in Huntington's disease
Phosphorylation of myelin regulatory factor by <span>PRKG</span> 2 mediates demyelination in Huntington's disease Open
Demyelination is a common pathological feature of a large number of neurodegenerative diseases including multiple sclerosis and Huntington's disease (HD). Laquinimod (LAQ) has been found to have therapeutic effects on multiple sclerosis an…
View article: MiR-34a suppresses HNSCC growth through modulating cell cycle arrest and senescence
MiR-34a suppresses HNSCC growth through modulating cell cycle arrest and senescence Open
MiR-34a acts as a tumor suppressor in various malignancies. In HNSCC, the role of miR-34a in proliferation has not been fully elaborated and the target genes are still bind. Here, we addressed that forced miR-34a expression induced cell cy…
View article: Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression
Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression Open
AMPD1 is an adenosine monophosphate deaminase that catalyzes the deamination of AMP to IMP. To understand the physiological function of AMPD1, we obtained a strain of Ampd1 mutant mice from KOMP repository, which was generated by a knockou…