Yanting Xing
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View article: Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation
Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation Open
Genetic interactions are adaptive within a species. Hybridization can disrupt such species‐specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to …
View article: Modulating Nanodroplet Formation En Route to Fibrillization of Amyloid Peptides with Designed Flanking Sequences
Modulating Nanodroplet Formation En Route to Fibrillization of Amyloid Peptides with Designed Flanking Sequences Open
Soluble oligomers populating early amyloid aggregation can be regarded as nanodroplets of liquid-liquid phase separation (LLPS). Amyloid peptides typically contain hydrophobic aggregation-prone regions connected by hydrophilic linkers and …
View article: Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles
Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles Open
Amyloid aggregation is a ubiquitous form of protein misfolding underlying the pathologies of Alzheimer's disease (AD), Parkinson's disease (PD) and type 2 diabetes (T2D), three primary forms of human amyloid diseases. While much has been l…
View article: The Bike-Sharing Rebalancing Problem Considering Multi-Energy Mixed Fleets and Traffic Restrictions
The Bike-Sharing Rebalancing Problem Considering Multi-Energy Mixed Fleets and Traffic Restrictions Open
Nowadays, as a low-carbon and sustainable transport mode bike-sharing systems are increasingly popular all over the world, as they can reduce road congestion and decrease greenhouse gas emissions. Aiming at the problem of the mismatch of b…
View article: Amyloid Aggregation under the Lens of Liquid–Liquid Phase Separation
Amyloid Aggregation under the Lens of Liquid–Liquid Phase Separation Open
Increasing experiments suggest that amyloid peptides can undergo liquid-liquid phase separation (LLPS) before the formation of amyloid fibrils. However, the exact role of LLPS in amyloid aggregation at the molecular level remains elusive. …
View article: Morphological Determinants of Carbon Nanomaterial-Induced Amyloid Peptide Self-Assembly
Morphological Determinants of Carbon Nanomaterial-Induced Amyloid Peptide Self-Assembly Open
Hybridizing carbon nanomaterials (CNMs) with amyloid fibrils-the ordered nanostructures self-assembled by amyloidogenic peptides-has found promising applications in bionanotechology. Understanding fundamental interactions of CNMs with amyl…
View article: Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding
Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding Open
Alzheimer's disease (AD) is the most severe form of neurological disorder, characterized by the presence of extracellular amyloid-β (Aβ) plaques and intracellular tau tangles. For decades, therapeutic strategies against the pathological sy…
View article: Peptide Self‐Assembly: Amyloid Self‐Assembly of hIAPP8‐20 via the Accumulation of Helical Oligomers, α‐Helix to β‐Sheet Transition, and Formation of β‐Barrel Intermediates (Small 18/2019)
Peptide Self‐Assembly: Amyloid Self‐Assembly of hIAPP8‐20 via the Accumulation of Helical Oligomers, α‐Helix to β‐Sheet Transition, and Formation of β‐Barrel Intermediates (Small 18/2019) Open
In article number 1805166, Pu Chun Ke, Feng Ding, and co-workers study the amyloid self-assembly of human islet amyloid polypeptide (hIAPP)8-20, a process associated with many neurodegenerative diseases and diabetes. The peptide is found t…
View article: Amyloid Self‐Assembly of hIAPP8‐20 via the Accumulation of Helical Oligomers, α‐Helix to β‐Sheet Transition, and Formation of β‐Barrel Intermediates
Amyloid Self‐Assembly of hIAPP8‐20 via the Accumulation of Helical Oligomers, α‐Helix to β‐Sheet Transition, and Formation of β‐Barrel Intermediates Open
The self‐assembly of human islet amyloid polypeptide (hIAPP) into β‐sheet‐rich nanofibrils is associated with the pathogeny of type 2 diabetes. Soluble hIAPP is intrinsically disordered with N‐terminal residues 8–17 as α‐helices. To unders…
View article: Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide
Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide Open
Micellar lysophosphatidylcholine inhibits the aggregation of human islet amyloid polypeptide (IAPP).