Yanwei Shen
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View article: Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer
Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer Open
Background: Previous clinical studies have suggested that Toll-like receptor (TLR)2 had predictive function for endocrine resistance in HER2-positive breast cancer (BCa). Nevertheless, it remains unclear whether TLR2 would relate to develo…
View article: Genomic Alterations Correlated to Trastuzumab Resistance and Clinical Outcomes in HER2+/HR- Breast Cancers of Patients Living in Northwestern China
Genomic Alterations Correlated to Trastuzumab Resistance and Clinical Outcomes in HER2+/HR- Breast Cancers of Patients Living in Northwestern China Open
Anti-HER2 therapy has significantly improved the survival rates of patients with HER2+ breast cancer. However, a subset of these patients eventually experience treatment failure, and the underlying genetic mechanisms remain largely unexplo…
View article: The regulatory roles of T helper cells in distinct extracellular matrix characterization in breast cancer
The regulatory roles of T helper cells in distinct extracellular matrix characterization in breast cancer Open
Background Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The ECM has been recognized as an important determinant of breast cancer progression and prognosis. Recent studies have revealed a strong link bet…
View article: Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer
Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer Open
Long non-coding ribonucleic acid 01555 (linc01555) is a brand-new long non-coding RNA (lncRNA) that acts a carcinogenic function in various cancers. However, its role in small cell lung cancer (SCLC) is uncertain. This research was to figu…
View article: Neoantigen vaccine and neoantigen‐specific cell adoptive transfer therapy in solid tumors: Challenges and future directions
Neoantigen vaccine and neoantigen‐specific cell adoptive transfer therapy in solid tumors: Challenges and future directions Open
The phenomenon of tumor hierarchy and genetic instability can be explained by the “two‐hits theory” and results in the occurrence of many somatic mutations. The expression of nonsynonymous mutations results in the production of mutant prot…
View article: Construction of a Prognostic Nomogram Model for Patients with Mucinous Breast Cancer
Construction of a Prognostic Nomogram Model for Patients with Mucinous Breast Cancer Open
Objective. The objective of the study is to develop a nomogram for estimating three- and five-year survival rates in mucinous breast cancer patients. Methods. Between 2010 and 2016, the National Cancer Institute's Surveillance, Epidemiolog…
View article: Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer
Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer Open
Long non-coding ribonucleic acid 01555 (linc01555) is a brand-new long non-coding RNA (lncRNA) that acts a carcinogenic function in various cancers. However, its role in small cell lung cancer (SCLC) is uncertain. This research was to figu…
View article: A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study
A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study Open
Background 5–10% of patients are diagnosed with metastatic breast cancer (MBC) at the initial diagnosis. This study aimed to develop a nomogram to predict the overall survival (OS) of these patients. Methods de novo MBC patients diagnosed …
View article: RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1
RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1 Open
Lung carcinoma is a prominent cause of mortality among patients with cancer. Previous studies have reported the vital role of long non‑coding RNAs (lncRNAs) in the malignant progression of lung cancer. lncRNA RP11‑284F21.9 was originally i…
View article: The functions and clinical applications of tumor-derived exosomes
The functions and clinical applications of tumor-derived exosomes Open
Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm. They can be secreted by all cell types and transfer information in the form of their contents, which include proteins, lipids and nucleic acids, to other cells t…
View article: Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin Open
Background A promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion and oxygenation of tumor vasculature. Thalidomide (Thal) has been shown to increase the ant…
View article: SUN-277 SCAVENGING OF LIPID ALDEHYDES LESSENS KIDNEY INJURY-DRIVEN ATHEROSCLEROSIS
SUN-277 SCAVENGING OF LIPID ALDEHYDES LESSENS KIDNEY INJURY-DRIVEN ATHEROSCLEROSIS Open
Chronic kidney disease (CKD) accelerates atherogenesis. Reactive aldehydes, including isoprostanes and isolevuglandins (IsoLG) are lipoxidation products carried by high density lipoprotein (HDL). These aldehydes promote cellular dysfunctio…
View article: Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer Open
Growing evidence indicates that Angiomotin (Amot)-p130 and Amot-p80 have different physiological functions. We hypothesized that Amot-p130 is a tumor suppressor gene in breast cancer, in contrast with the canonical oncogenicity of Amot-p80…
View article: Additional file 2: of Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
Additional file 2: of Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin Open
Table S1. List of differentially expressed proteins between control tumors and Thal-treated tumors. (XLS 46 kb)
View article: Comparative Analysis of Outcomes and Clinicopathological Characteristics of Synchronous and Metachronous Contralateral Breast Cancer: A Study of the SEER Database
Comparative Analysis of Outcomes and Clinicopathological Characteristics of Synchronous and Metachronous Contralateral Breast Cancer: A Study of the SEER Database Open
The characteristics and outcomes of sCBCs and mCBCs were substantially different. sCBC and mCBC patients may have different prognosis, and the prognosis of CBC depends on the first and second tumors.
View article: Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis
Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis Open
Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently ne…
View article: AmotP130 regulates Rho <scp>GTP</scp>ase and decreases breast cancer cell mobility
AmotP130 regulates Rho <span>GTP</span>ase and decreases breast cancer cell mobility Open
Angiomotin (Amot) is a newly discovered, multifunctional protein that is involved in cell migration and angiogenesis. However, the role of its isoform, AmotP130, in the regulation of cytoskeleton and metastasis of breast cancer, is unclear…
View article: The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012
The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012 Open
The overall risk of SPCRC increased among patients with both prior RCC and LCC, but not among those with ReC. The different survival outcomes in CRC survivors suffering from SPCRC were largely explained by the patient age but not by the pr…
View article: Clinicopathological features and survival of early stage breast cancer in northwest China: A population‐based retrospective study of 1287 patients
Clinicopathological features and survival of early stage breast cancer in northwest China: A population‐based retrospective study of 1287 patients Open
Background Breast cancer (BC) displays different clinicopathological features and outcomes based on patient age, molecular subtype, and treatment. However, such features in BC patients in northwest China are unclear. This study investigate…
View article: Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma
Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma Open
The clinical outcomes and therapeutic strategies for infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma (ILC) are not uniform. The primary objectives of this study were to identify the differences in the clinical charac…
View article: Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer
Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer Open
Vasculogenic mimicry (VM), a newly defined pattern of tumor blood perfusion, describes the functional plasticity of aggressive tumor cells forming de novo vascular networks and is associated with the cancer progression and metastasis. Howe…
View article: Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors
Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumors Open
The aim of this study was to determine the clinical features, treatment factors, and prognosis of patients with multiple primary malignant tumors (MPMTs). In total, 161 patients with MPMTs at our hospital (The First Affiliated Hospital of …
View article: Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis
Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis Open
Various studies have evaluated the significance of PTEN (phosphatase and tensin homolog deleted from chromosome 10) expression in breast cancer, but their results remain controversial. We conducted a meta-analysis to evaluate the associati…
View article: Incidence and survival differences in esophageal cancer among ethnic groups in the United States
Incidence and survival differences in esophageal cancer among ethnic groups in the United States Open
Histological type distribution between racial groups could be an important consideration in the incidence and the survival trend but other factors could also have an effect.
View article: Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study
Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study Open
Risk of SPMs increases in CRC survivors, especially in the first 5 years after prior diagnosis. Intensive surveillance should be advocated among young patients, with specific attention to the small intestine, colorectum, renal pelvis, and …
View article: Angiomotin Family Members: Oncogenes or Tumor Suppressors?
Angiomotin Family Members: Oncogenes or Tumor Suppressors? Open
Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and th…
View article: Importance of the interaction between immune cells and tumor vasculature mediated by thalidomide in cancer treatment (Review)
Importance of the interaction between immune cells and tumor vasculature mediated by thalidomide in cancer treatment (Review) Open
Over the past 60 years, thalidomide has metamorphosized from a drug prescribed to treat morning sickness in pregnant women, which was subsequently found to induce birth defects, into a highly effective therapy for treating leprosy and mult…