Yanwen Zhang
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View article: Genome-Wide Identification and Expression Profiling of the GRAS Gene Family in Taxus cuspidate
Genome-Wide Identification and Expression Profiling of the GRAS Gene Family in Taxus cuspidate Open
Background: The GRAS transcription factor family plays pivotal regulatory roles in plant growth and development, hormone signaling, and responses to environmental stresses. Taxus cuspidata, an endangered and nationally protected conifer sp…
View article: FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer
FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer Open
Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene, is notably upregulated in various malignancies, including triple-negative breast cancer, pancreatic ductal adenocarcinoma, and colon carcinoma, and potentially mediates…
View article: Coronary artery calcification and cardiovascular outcome as assessed by intravascular OCT and artificial intelligence
Coronary artery calcification and cardiovascular outcome as assessed by intravascular OCT and artificial intelligence Open
Coronary artery calcification (CAC) is a marker of atherosclerosis and is thought to be associated with worse clinical outcomes. However, evidence from large-scale high-resolution imaging data is lacking. We proposed a novel deep learning …
View article: Nitazoxanide ameliorates OVA-induced airway inflammation in asthmatic mice via p38-MAPK/NFkB and AMPK/STAT3 pathways
Nitazoxanide ameliorates OVA-induced airway inflammation in asthmatic mice via p38-MAPK/NFkB and AMPK/STAT3 pathways Open
Nitazoxanide has an anti-inflammatory effect, we clarified the ameliorative effect of nitazoxanide on asthmatic airway inflammation by conducting in vitro and in vivo experiments. In vitro, we assessed the effect of nitazoxanide on cytokin…
View article: MiR-185-5p measurement assists in reflecting Th1/Th2 cell imbalance, inflammatory cytokine production, and exacerbation risk for childhood asthma
MiR-185-5p measurement assists in reflecting Th1/Th2 cell imbalance, inflammatory cytokine production, and exacerbation risk for childhood asthma Open
Background: MicroRNA (miR)-185-5p participates in the pathology of asthma by regulating immune imbalance, inflammation, periostin synthesis, and smooth muscle contraction. This study intended to explore the dysregulation of miR-185p and it…
View article: Analysis of Psychiatric Symptoms and Suicide Risk Among Younger Adults in China by Gender Identity and Sexual Orientation
Analysis of Psychiatric Symptoms and Suicide Risk Among Younger Adults in China by Gender Identity and Sexual Orientation Open
Importance Younger adults in China who are transgender and gender nonconforming (TGNC) and lesbian, gay, and bisexual (LGB) experience high levels of minority stress (eg, stigma and bullying) and adverse mental health symptoms. However, th…
View article: A multicomponent digital intervention to promote help-seeking for mental health problems and suicide in sexual and gender diverse young adults: A randomized controlled trial
A multicomponent digital intervention to promote help-seeking for mental health problems and suicide in sexual and gender diverse young adults: A randomized controlled trial Open
Background LGBTQ+ community’s higher susceptibility to worse mental health outcomes and more help-seeking barriers compared to the cis -heterosexual population. Despite the LGBTQ+ population facing higher mental health risks, there has bee…
View article: Rates of breastfeeding or chestfeeding and influencing factors among transgender and gender-diverse parents: a cross sectional study
Rates of breastfeeding or chestfeeding and influencing factors among transgender and gender-diverse parents: a cross sectional study Open
There are no funding sources to declare.
View article: Small Noncoding RNAs Contribute to Sperm Oxidative Stress‐Induced Programming of Behavioral and Metabolic Phenotypes in Offspring
Small Noncoding RNAs Contribute to Sperm Oxidative Stress‐Induced Programming of Behavioral and Metabolic Phenotypes in Offspring Open
There is growing evidence that paternal environmental information alters small noncoding RNAs (sncRNAs) in sperm and in turn can induce alterations of metabolic and behavioral phenotypes of the next generation. However, the potential media…
View article: 1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells
1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells Open
Background: With the global popularity of communication devices such as mobile phones, there are increasing concerns regarding the effect of radiofrequency electromagnetic radiation (RF-EMR) on the brain, one of the most important organs s…
View article: Examination of Salivary Secretion and Salivary Cortisol Concentration by Scent Stimulation
Examination of Salivary Secretion and Salivary Cortisol Concentration by Scent Stimulation Open
現在，ストレス社会により唾液量が減少し口腔乾燥を訴える患者が増えている．唾液量の減少は，歯科口腔疾患だけでなく，嚥下障害にも関連し全身の健康に影響を与える．我々は唾液分泌を促進する簡便で安全な方法としてにおい刺激に着目し，本研究ではパイナップルの香り刺激に対する唾液量と唾液中コルチゾール濃度への影響を検討することを目的とした．健常成人10名を対象に，香りなし試行と香りあり試行の2試行を実施させ，実験中の唾液量と唾液中コルチゾール濃度を測定した．香りあり試行では，パイナップル…
View article: 1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling
1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling Open
The increasing intensity of environmental radiofrequency electromagnetic fields (RF-EMF) has increased public concern about its health effects. Of particular concern are the influences of RF-EMF exposure on the development of the brain. Th…
View article: Control of patterns of symmetric cell division in the epidermal and cortical tissues of the Arabidopsis root
Control of patterns of symmetric cell division in the epidermal and cortical tissues of the Arabidopsis root Open
Controlled cell division is central to the growth and development of all multicellular organisms. Within the proliferating zone of the Arabidopsis root, regular symmetric divisions give rise to patterns of parallel files of cells, the gene…
View article: Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review)
Human leukocyte antigen‑G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review) Open
Human leukocyte antigen-G (HLA-G) is a non-classical HLA molecule, predominantly expressed in cytotrophoblast cells to protect the fetus during pregnancy. Notably, a high frequency of HLA-G expression has been observed in a wide variety of…
View article: Selection and Validation of Appropriate Reference Genes for Quantitative Real-Time PCR Normalization in Staminate and Perfect Flowers of Andromonoecious Taihangia rupestris
Selection and Validation of Appropriate Reference Genes for Quantitative Real-Time PCR Normalization in Staminate and Perfect Flowers of Andromonoecious Taihangia rupestris Open
Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) is the most commonly used and powerful method for gene expression analysis due to its high sensitivity, specificity, and high throughput, and the accuracy of …
View article: Extremely Low-Frequency Electromagnetic Fields Promote In Vitro Neuronal Differentiation and Neurite Outgrowth of Embryonic Neural Stem Cells via Up-Regulating TRPC1
Extremely Low-Frequency Electromagnetic Fields Promote In Vitro Neuronal Differentiation and Neurite Outgrowth of Embryonic Neural Stem Cells via Up-Regulating TRPC1 Open
Exposure to extremely low-frequency electromagnetic fields (ELF-EMFs) can enhance hippocampal neurogenesis in adult mice. However, little is focused on the effects of ELF-EMFs on embryonic neurogenesis. Here, we studied the potential effec…