Yanxi Ji
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View article: Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification
Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification Open
Rapid and accurate detection of infectious virus particles, not just viral nucleic acid, is essential to avoid unnecessary quarantine and effectively control the spread of viral diseases such as coronavirus disease 2019 (COVID-19), severe …
View article: Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses Open
Introduction Understanding the intricacies of the host inflammatory response to coronaviruses is essential for developing effective therapeutic strategies to mitigate the severe consequences of these infections. Various coronaviruses can t…
View article: Evidence for fomite transmission of SARS‐CoV‐2 Omicron variant in a mouse model
Evidence for fomite transmission of SARS‐CoV‐2 Omicron variant in a mouse model Open
Impact statement Throughout the COVID‐19 pandemic, the risk of fomite‐based transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has not been systematically investigated. In this study, we employed the K18‐hACE2 mou…
View article: Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses
Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses Open
View article: Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2
Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2 Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially described to target the respiratory system and now has been reported to infect a variety of cell types, including cardiomyocytes, neurons, hepatocytes, and gut …
View article: The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus driving the ongoing coronavirus disease 2019 (COVID-19) pandemic, continues to rapidly evolve. Because of the limited efficacy of vaccination in prevention of SARS-CoV…
View article: Comparison of model‐specific histopathology in mouse models of COVID‐19
Comparison of model‐specific histopathology in mouse models of COVID‐19 Open
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has been identified as the causative agent of the current coronavirus disease 2019 pandemic. Development of animal models that parallel the clinical and pat…
View article: The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency
The Impact of Accumulated Mutations in SARS-CoV-2 Variants on the qPCR Detection Efficiency Open
SARS-CoV-2 is evolving with mutations throughout the genome all the time and a number of major variants emerged, including several variants of concern (VOC), such as Delta and Omicron variants. In this study, we demonstrated that mutations…
View article: Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells Open
View article: A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery
A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery Open
View article: P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus Open
Interferon-inducible p200 family protein IFI204 was reported to be involved in DNA sensing, and subsequently induces the production of type I interferons and proinflammatory mediators. However, its function in the regulation of antiviral i…
View article: The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells
The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells Open
RNA interference (RNAi) is a process of eukaryotic posttranscriptional gene silencing that functions in antiviral immunity in plants, nematodes, and insects. However, recent studies provided strong supports that RNAi also plays a role in a…