Yumeng Jia
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View article: Regrowth and Yield Formation of ‘Qingtian No. 1’ Oat in Response to Cutting Management
Regrowth and Yield Formation of ‘Qingtian No. 1’ Oat in Response to Cutting Management Open
The optimization of mowing management is crucial for establishing a high-yielding “one sowing, two harvests” system for oat (Avena sativa L.) forage production in the alpine regions of the Tibetan Plateau. This study aimed to identify the …
View article: Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF
Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF Open
Background: Disrupted cardiomyocyte energy metabolism is a hallmark of heart failure with preserved ejection fraction (HFpEF). Succinate, a key intermediate of the tricarboxylic acid cycle, is markedly decreased in HFpEF myocardium. Beyond…
View article: Association between intake of various sugar subtypes and common mental disorders: A large prospective study
Association between intake of various sugar subtypes and common mental disorders: A large prospective study Open
Excessive sugar consumption elevates the risks of depression, anxiety, and self-harm, whereas moderate intake demonstrates protective effects, particularly in obese populations. These U/J-shaped dose-response relationships inform our propo…
View article: Analysis of deformation rule of deep foundation pit excavation of railway station in soft soil with silt
Analysis of deformation rule of deep foundation pit excavation of railway station in soft soil with silt Open
This study investigates the behavior of retaining structures and the settlement of external surfaces in deep foundation pits located in areas characterized by muddy soft soil. The research evaluates the efficacy of two constitutive models-…
View article: Adversarial Curriculum Graph-Free Knowledge Distillation for Graph Neural Networks
Adversarial Curriculum Graph-Free Knowledge Distillation for Graph Neural Networks Open
Data-free Knowledge Distillation (DFKD) is a method that constructs pseudo-samples using a generator without real data, and transfers knowledge from a teacher model to a student by enforcing the student to overcome dimensional differences …
View article: Advances of the Gut and Vaginal Microbiota in Ovarian Cancer
Advances of the Gut and Vaginal Microbiota in Ovarian Cancer Open
Ovarian cancer remains a global health challenge characterized by frequently delayed diagnosis and alarming mortality rates. Recent progress in the crosstalk between gut and vaginal microbiomes in ovarian cancer provides new insights into …
View article: Bufalin Suppresses Esophageal Squamous Cell Carcinoma Progression through Protein Arginine Methyltransferase-6/AKT/Mammalian Target of Rapamycin Pathway Inhibition
Bufalin Suppresses Esophageal Squamous Cell Carcinoma Progression through Protein Arginine Methyltransferase-6/AKT/Mammalian Target of Rapamycin Pathway Inhibition Open
Objective: Esophageal squamous cell carcinoma (ESCC), a commonly encountered malignant tumor in the gastrointestinal tract, poses a significant health burden. Bufalin, a pharmacologically active molecule, has been shown to exhibit antitumo…
View article: Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease
Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease Open
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable…
View article: Machine Learning‐Based Integration of Single‐Cell and Bulk Transcriptome Reveals Coagulation Signature and Phenotypic Heterogeneity in Hepatocellular Carcinoma
Machine Learning‐Based Integration of Single‐Cell and Bulk Transcriptome Reveals Coagulation Signature and Phenotypic Heterogeneity in Hepatocellular Carcinoma Open
Primary liver cancer ranks as the third most lethal cancer globally, with hepatocellular carcinoma (HCC) being the most prevalent pathologic type. The liver plays a crucial role in maintaining normal coagulation function by synthesising, r…
View article: Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study
Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study Open
Background Despite growing awareness of the mental health damage caused by air pollution, the epidemiologic evidence on impact of air pollutants on major mental disorders (MDs) remains limited. We aim to explore the impact of various air p…
View article: A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders
A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders Open
Accelerated biological aging is significantly associated with the incidence of several musculoskeletal disorders. These insights highlight the importance of biological age assessments in gauging musculoskeletal disorder risk, aiding early …
View article: Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report
Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report Open
Introduction Brodifacoum is a highly potent superwarfarin rodenticide that leads to coagulopathy. Although the effect of warfarin during pregnancy is well understood, reports on superwarfarin poisoning, like brodifacoum, during pregnancy a…
View article: Catheter ablation in a monochorionic diamniotic twin pregnancy: A case report and literature review
Catheter ablation in a monochorionic diamniotic twin pregnancy: A case report and literature review Open
Rationale: Preexcitation syndrome is an uncommon congenital cardiac disorder that impairs the normal cardiac conduction system. Radiofrequency ablation is one of the most effective treatments for this condition. Nevertheless, radiofrequenc…
View article: Global research trends and hotspots in gestational diabetes and long-term cardiovascular health: A bibliometric analysis
Global research trends and hotspots in gestational diabetes and long-term cardiovascular health: A bibliometric analysis Open
This is the first bibliometric analysis linking CVD and GDM. Future research should investigate pathways between GDM and CVD, emphasizing gene expression and inflammation, while advocating for collaborative prevention strategies.
View article: A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety
A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety Open
Our study identified the joint effects of air pollution with genetic susceptibility on the risk of depression and anxiety, and provided several novel candidate genes for the interaction, contributing to an understanding of the genetic arch…
View article: Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease Open
CTGF plays a crucial role in the development of KBD. Curcumin has shown potential in inhibiting CTGF levels and reducing chondrocyte apoptosis, highlighting its promise as a therapeutic agent for preventing cartilage damage in KBD. Our fin…
View article: FODA-PG for Enhanced Medical Imaging Narrative Generation: Adaptive Differentiation of Normal and Abnormal Attributes
FODA-PG for Enhanced Medical Imaging Narrative Generation: Adaptive Differentiation of Normal and Abnormal Attributes Open
Automatic Medical Imaging Narrative generation aims to alleviate the workload of radiologists by producing accurate clinical descriptions directly from radiological images. However, the subtle visual nuances and domain-specific terminology…
View article: A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals
A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals Open
Objective This study aimed to identify candidate loci and genes related to sleep disturbances in depressed individuals and clarify the co-occurrence of sleep disturbances and depression from the genetic perspective. Methods The study subje…
View article: Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin–Beck Disease and Osteoarthritis Patients
Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin–Beck Disease and Osteoarthritis Patients Open
The aim of this study was to provide a comprehensive understanding of similarities and differences in mRNAs, lncRNAs, and circRNAs within cartilage for Kashin–Beck disease (KBD) compared to osteoarthritis (OA). We conducted a comparison of…
View article: Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders
Exploring the Interplay between Mitochondrial DNA and Lifestyle Factors in the Pathogenesis of Psychiatric Disorders Open
The objectives of this study were to investigate the interaction of mitochondrial DNA (mtDNA) and lifestyle factors in the development of psychiatric disorders and to gain greater insight into their pathogenesis and comorbidity. We analyze…
View article: Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort
Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort Open
Background The identification of suitable biomarkers is of crucial clinical importance for the early diagnosis of treatment-resistant schizophrenia (TRS). This study aims to comprehensively analyze the association between TRS and blood and…
View article: Enhanced polygenic risk score incorporating gene–environment interaction suggests the association of major depressive disorder with cardiac and lung function
Enhanced polygenic risk score incorporating gene–environment interaction suggests the association of major depressive disorder with cardiac and lung function Open
Background Depression has been linked to an increased risk of cardiovascular and respiratory diseases; however, its impact on cardiac and lung function remains unclear, especially when accounting for potential gene–environment interactions…
View article: Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination
Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination Open
T-2 toxin and deoxynivalenol (DON) are two prevalent mycotoxins that cause cartilage damage in Kashin–Beck disease (KBD). Cartilage extracellular matrix (ECM) degradation in chondrocytes is a significant pathological feature of KBD. It has…
View article: Three-dimensional spatial orbital angular momentum holography
Three-dimensional spatial orbital angular momentum holography Open
The degree of freedom of orbital angular momentum of light has been used as a new information carrier in optical holographic information processing technology. However, current research on orbital angular momentum holography mainly focuses…