Yanxia Chu
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Hepatic insulin sensitivity is improved in high‐fat diet‐fed <i>Park2</i> knockout mice in association with increased hepatic AMPK activation and reduced steatosis Open
Park2 is an E3 ubiquitin ligase known for its role in mitochondrial quality control via the mitophagy pathway. Park2 KO mice are protected from diet-induced obesity and hepatic insulin sensitivity is improved in high-fat diet (HFD)-fed Par…
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is the most common and devastating of the interstitial lung diseases. Epithelial dysfunction is thought to play a prominent role in disease pathology, and we sought to characterize secreted signals that …
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance Open
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we inves…
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance Open
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we inves…
Association of genetic variation in <em>COMT</em> gene with pain related to sickle cell disease in patients from the walk-PHaSST study Open
COMT functional variants may predispose SCD patients to worse acute pain in women. The association of COMT variants with the intensity of self-reported acute pain warrants further genetic study of pain perception in SCD.
Variable Susceptibility to Cigarette Smoke–Induced Emphysema in 34 Inbred Strains of Mice Implicates <i>Abi3bp</i> in Emphysema Susceptibility Open
Chronic obstructive pulmonary disease (COPD) is caused by a complex interaction of environmental exposures, most commonly cigarette smoke, and genetic factors. Chronic cigarette smoke exposure in the mouse is a commonly used animal model o…
Loss of Twist1 in the Mesenchymal Compartment Promotes Increased Fibrosis in Experimental Lung Injury by Enhanced Expression of CXCL12 Open
Idiopathic pulmonary fibrosis (IPF) is a disease characterized by the accumulation of apoptosis-resistant fibroblasts in the lung. We have previously shown that high expression of the transcription factor Twist1 may explain this prosurviva…
Thrombospondin‐1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia Open
Sickle cell disease (SCD) is known to promote end-organ damage over time. Patients with especially high rates of intravascular hemolysis in SCD have decreased nitric oxide (NO) bioavailability, which is associated with vasculopathy and pul…
Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1 Open
The wingless pathway has a powerful influence on bone metabolism and is a therapeutic target in skeletal disorders. Wingless signaling is mediated in part through the Frizzled (FZD) receptor family. FZD transcriptional regulation is poorly…
P049 Loss of Twist1 in Colα2(I)+ Cells Promotes Increased Fibrosis in Experimental Lung Injury Through C-X-C Motif Ligand 12 (CXCL12) Open
emphysema or EE < 15% (p ¼ 0.037).Mean decline in absolute DLco (% predicted) was 3.5% in patients with EE 15% versus 3.3% in patients with no emphysema or EE < 15% (p ¼ 0.872).Mean change in CPI was 1.9 in patients with EE 15% versus 2.7 …
Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies Open
IPF is characterized by the loss of RXFP1 expression. RXFP1 expression is directly associated with pulmonary function in patients with IPF. The relaxin-like effects of CGEN25009 in vitro are dependent on expression of RXFP1. Our data sugge…