Yanxia Huang
YOU?
Author Swipe
View article: Ideal cardiovascular health and its associated factors among young people in Zhuhai, China: a cross-sectional study
Ideal cardiovascular health and its associated factors among young people in Zhuhai, China: a cross-sectional study Open
Objective To investigate the status of ideal cardiovascular health (CVH) among young individuals in Zhuhai, China, and analyse the factors that affect it, providing a basis for formulating prevention strategies for cardiovascular diseases …
View article: The value of combined thromboelastography test for the early prediction of disease severity in patients with haemorrhagic fever of renal syndrome and the construction of a critical model
The value of combined thromboelastography test for the early prediction of disease severity in patients with haemorrhagic fever of renal syndrome and the construction of a critical model Open
Background Thromboelostograms (TEG) are indicators that reflect the dynamic changes in blood coagulation objectively. Compared with traditional coagulation tests, TEG are easy to perform; imparting a head start in determining patients’coag…
View article: Pneumonia, a pulmonary abscess, and an empyema caused by Parvimonas micra
Pneumonia, a pulmonary abscess, and an empyema caused by Parvimonas micra Open
Background: Pneumonia with an empyema caused by anaerobic bacteria is rare but can be life-threatening, especially in immunocompromised patients. Case presentation: A 67-year-old man with diabetes and hypertension who presented with pneumo…
View article: Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma
Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma Open
The findings of this survey study suggest that social support was associated with higher QOL and lower FT in HCC patients. Future investigations focusing on targeted social support interventions may enhance QOL and reduce FT in HCC patient…
View article: Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics
Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics Open
The article provides an overview of the current understanding of the interplay between metabolic pathways and immune function in the context of triple-negative breast cancer (TNBC). It highlights recent advancements in single-cell and spat…
View article: Thiophene-backbone arcuate graphene nanoribbons: shotgun synthesis and length dependent properties
Thiophene-backbone arcuate graphene nanoribbons: shotgun synthesis and length dependent properties Open
The modular synthesis of graphene nanoribbons represents a highly efficient approach for producing GNRs with diverse structures and functionalities.
View article: Thiophene-backbone Arcuate Graphene Nanoribbons: Shotgun Synthesis and Length-dependent Properties
Thiophene-backbone Arcuate Graphene Nanoribbons: Shotgun Synthesis and Length-dependent Properties Open
Efficient synthetic methods are urgently needed to produce graphene nanoribbons (GNRs) with diverse structures and functions. Precise control over the topological edges of GNRs is also crucial for achieving diverse molecular topologies and…
View article: Prediction of 90 day readmission in heart failure with preserved ejection fraction by interpretable machine learning
Prediction of 90 day readmission in heart failure with preserved ejection fraction by interpretable machine learning Open
Aims Certain critical risk factors of heart failure with preserved ejection fraction (HFpEF) patients were significantly different from those of heart failure with reduced ejection fraction (HFrEF) patients, resulting in the limitations of…
View article: SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids
SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids Open
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals. However, whether and how aging brains are affected by Omicron variants in terms of neuroinvasiv…
View article: VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage Open
Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for a range of diseases, including ischemic stroke, myocardial infarction, and trauma. Following the restoration of blood flow post-tissue ischemia, oxidative stress c…
View article: Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis Open
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis. Objective To determine the effect of XBJ vs placebo on 28-day mortality am…
View article: Proppant embedment in rough fractures considering shale hydration
Proppant embedment in rough fractures considering shale hydration Open
Shale reservoirs are significantly hydrated owing to the presence of large amounts of clay minerals. However, the mechanical properties of the hydration layer on the rock surface decline, resulting in severe proppant embedding. In this stu…
View article: Novel compound heterozygous variants in the USH2A gene associated with autosomal recessive retinitis pigmentosa without hearing loss
Novel compound heterozygous variants in the USH2A gene associated with autosomal recessive retinitis pigmentosa without hearing loss Open
Background: Retinitis pigmentosa (RP) is a group of progressive inherited retinal dystrophies characterized by the primary degeneration of rod photoreceptors and the subsequent loss of cone photoreceptors because of cell death. It is cause…
View article: Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases Open
The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like pseudokinase (MLKL), represents a major breakthrough that has dra…
View article: Public awareness and attitudes toward biobank and sample donation: A regional Chinese survey
Public awareness and attitudes toward biobank and sample donation: A regional Chinese survey Open
Background The biobank is an extraordinary aid to research and scientific progress. Public involvement in biobanks, necessary for their development, is limited due to inadequate knowledge of biobanking and concerns about sample donation. T…
View article: Inca Peanut Seed Albumin Promotes the Retrogradation of Corn Starch
Inca Peanut Seed Albumin Promotes the Retrogradation of Corn Starch Open
While starch and protein are two major biopolymer components that usually coexist in foods, how protein influences starch retrogradation, and subsequently the food matrix structure and properties, is complex and dependent on factors such a…
View article: Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma Open
The purpose of this study was to investigate the effects of valdecoxib on the retina in retinal ischemia-reperfusion injury (IRI) and R28 cells following oxygen-glucose deprivation/recovery (OGD/R) injury, as well as the underlying mechani…
View article: A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells
A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells Open
Zika virus (ZIKV) infection can cause severe neurological diseases including neonatal microcephaly and Guillain-Barre syndrome. Long noncoding RNAs (lncRNAs) are the by-products of the transcription process, which are considered to affect …
View article: Due attention should be paid to persistent trigeminal artery in trigeminal neuralgia
Due attention should be paid to persistent trigeminal artery in trigeminal neuralgia Open
Objectives: Persistent trigeminal artery (PTA) is a rare anastomoses vessel, and also a rarely reported culprit vessel in trigeminal neuralgia (TN). In this study, we aimed to analysis the incidence of PTA in TN. Methods: 297 patients with…
View article: Comparing the Effect of Dexmedetomidine and Midazolam in Patients with Brain Injury
Comparing the Effect of Dexmedetomidine and Midazolam in Patients with Brain Injury Open
Background: Studies have shown that dexmedetomidine improves neurological function. Whether dexmedetomidine reduces mortality or improves quantitative electroencephalography (qEEG) among patients post-craniotomy remains unclear. Methods: T…
View article: Identification of novel heterozygous missense variant in the <i>COL11A1</i> causing fetal craniofacial anomalies
Identification of novel heterozygous missense variant in the <i>COL11A1</i> causing fetal craniofacial anomalies Open
Type XI collagen plays a fundamental role in fibrillogenesis, through formation of cartilage collagen fibrils and contributions to the cohesive properties of cartilage. The α-1 chain of type XI collagen is encoded by the COL11A1. Pathogeni…
View article: ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence
ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence Open
Cellular senescence severely limits the research and the application of dental pulp stem cells (DPSCs). A previous study conducted by our research group revealed a close implication of ROR2 in DPSC senescence, although the mechanism underl…
View article: Zika Virus and Its Association with Neurological Disorders
Zika Virus and Its Association with Neurological Disorders Open
Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blo…
View article: Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases
Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases Open
Stem cell therapies have shown promising therapeutic effects in restoring damaged tissue and promoting functional repair in a wide range of human diseases. Generations of insulin-producing cells and pancreatic progenitors from stem cells a…
View article: AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS
AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS Open
Apoptosis is an important cellular response to viral infection. In this study, we identified activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1) as a positive regulator of apoptosis triggered by double-stranded (ds)RNA. D…
View article: Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis
Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis Open
Dental pulp stem cells (DPSCs) play a vital role in tooth restoration, regeneration, and homeostasis. The link between DPSC senescence and tooth aging has been well‐recognized. ROR2 plays an important role in aging‐related gene expression.…