Yanyan Xing
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View article: Exploring Pruritus in Bullous Pemphigoid: Analysis of QOL Metrics and Potential Biological Mechanisms
Exploring Pruritus in Bullous Pemphigoid: Analysis of QOL Metrics and Potential Biological Mechanisms Open
Bullous pemphigoid is a devastating autoimmune blistering disease with need for improved therapeutics. Limited data are available on the overall burden of pruritus and alterations over time; however, treatment of itch-specific pathways may…
View article: MrgprC11<sup>+</sup> Jugular Neurons Control Airway Hyperresponsiveness in Allergic Airway Inflammation
MrgprC11<sup>+</sup> Jugular Neurons Control Airway Hyperresponsiveness in Allergic Airway Inflammation Open
The lung is densely innervated by sensory nerves, the majority of which are derived from the vagal sensory neurons. Vagal ganglia consist of two different ganglia, termed nodose and jugular ganglia, with distinct embryonic origins, innerva…
View article: Urinary bladder matrix scaffold improves the impact of adipose-mesenchymal stem cells on the function and structure of transplanted rat ovaries
Urinary bladder matrix scaffold improves the impact of adipose-mesenchymal stem cells on the function and structure of transplanted rat ovaries Open
Ovarian transplantation presents significant advantages for the preservation of female fertility. Nonetheless, a substantial number of follicles are apoptosis during the process of ovarian tissue transplantation as a result of ischemic con…
View article: [Functional investigation of chimeric antigen receptor T cells targeting LMP1 antigen].
[Functional investigation of chimeric antigen receptor T cells targeting LMP1 antigen]. Open
Objective: This study aimed to create a type of CAR-T cells that targets LMP1 antigen and study its immunotherapeutic effect on LMP1-positive hematological malignancies. Methods: To generate LMP1 CAR-T cells, a plasmid expressing LMP1 CAR …
View article: Effect of Adipose-derived Mesenchymal Stem Cells Combined With Urinary Bladder Matrix Scaffold on the Structure and Function of Autografted Rat Ovaries
Effect of Adipose-derived Mesenchymal Stem Cells Combined With Urinary Bladder Matrix Scaffold on the Structure and Function of Autografted Rat Ovaries Open
Background: Ovarian transplantation has unique advantages in the preservation of female fertility, especially in young women with cancer who need chemotherapy. However, a large number of follicles are lost because of ischemia during ovaria…
View article: MrgprC11 <sup>+</sup> sensory neurons mediate glabrous skin itch
MrgprC11 <sup>+</sup> sensory neurons mediate glabrous skin itch Open
Significance Chronic itch, associated with dermatologic or systemic diseases, is challenging to treat and significantly affects quality of life. In the past several decades, significant progress has been made to help us understand the mech…
View article: Visualizing the itch-sensing skin arbors
Visualizing the itch-sensing skin arbors Open
Diverse sensory neurons exhibit distinct neuronal morphologies with a variety of axon terminal arborizations used to subserve their functions. Due to its clinical significance, the molecular and cellular mechanisms of itch are being intens…
View article: Molecular signature of pruriceptive MrgprA3<sup>+</sup> neurons
Molecular signature of pruriceptive MrgprA3<sup>+</sup> neurons Open
Itch, initiated by the activation of sensory neurons, is frequently associated with dermatological or systemic diseases and significantly affects patient quality of life. MrgprA3 + sensory neurons have been identified as one of the major i…
View article: Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study
Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study Open
Alcoholic hepatitis (AH) develops in only a small proportion of heavy drinkers. To better understand the mechanisms underlying this disparity, we conducted a study to define the relationship between AH development and dysregulated immune r…