Yan‐Yi Jiang
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View article: Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia
Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia Open
Background The mesenchymal (MES) subtype of glioblastoma (GBM) is believed to be influenced by both cancer cell-intrinsic alterations and extrinsic cellular interactions, yet the underlying mechanisms remain unexplored. Methods Identificat…
View article: Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma Open
View article: Perioperative immunotherapy for esophageal squamous cell carcinoma
Perioperative immunotherapy for esophageal squamous cell carcinoma Open
Esophageal squamous cell carcinoma (ESCC) is the main prevalent histological subtype and accounts for 85% of esophageal cancer cases worldwide. Traditional treatment for ESCC involves chemotherapy, radiotherapy, and surgery. However, the o…
View article: Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells Open
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the nucleus remains unknown. The nuclear pore complex (NPC) m…
View article: Super-enhancers complexes zoom in transcription in cancer
Super-enhancers complexes zoom in transcription in cancer Open
View article: Data from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Data from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway Open
Protein kinase Cι (PKCι) is an atypical PKC isoform and participates in multiple aspects of the transformed phenotype in human cancer cells. We previously reported that frequent amplification and overexpression of PKCι were correlated with…
View article: Supplementary Figures S1-S5 from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Supplementary Figures S1-S5 from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway Open
Supplementary Figures S1-S5.
View article: Data from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Data from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway Open
Protein kinase Cι (PKCι) is an atypical PKC isoform and participates in multiple aspects of the transformed phenotype in human cancer cells. We previously reported that frequent amplification and overexpression of PKCι were correlated with…
View article: Supplementary Figures S1-S5 from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway
Supplementary Figures S1-S5 from Atypical Protein Kinase Cι (PKCι) Promotes Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing Resistance to Anoikis via PKCι-SKP2-AKT Pathway Open
Supplementary Figures S1-S5.
View article: Figure S5 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Figure S5 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
mRNA expression of ANO1 in ESCC cell lines. X. Name of ESCC cell lines. Y. The relative mRNA expression of ANO1 compared with GAPDH.
View article: Supplement File from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Supplement File from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
Supplement file: Materials and Methods
View article: Supplementary Figure 3 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Figure 3 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Figure 3. Western blot analysis in ESCC cells treated with or without 100 μmol/L KN-93 for 24 hours.
View article: Data from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Data from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Open
Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefi…
View article: Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Purpose: We previously revealed that the calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal squamous carcinoma ce…
View article: Supplementary Figures from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
Supplementary Figures from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open
Supplementary Figure 1. Distribution of putative targets of the top-ranked small molecules Supplementary Figure 2. CDK7 silencing significantly inhibited cells growth Supplementary Figure 3. Cell viability assay of C666-1 cells treated wit…
View article: Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southeast Asia and Southern China. The pathogenic mechanisms of NPC, particularly those involving epigenetic dysregulation, remain largely elusive, ha…
View article: Supplementary Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Data. Supplementary Materials and Methods, Supplementary Figure Legends
View article: Supplementary Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Data from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Data. Supplementary Materials and Methods, Supplementary Figure Legends
View article: Supplementary Table 2 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Table 2 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Table 2. Relationship between NRP1/CRT co-expression and lymph node metastasis in 216 ESCC patients
View article: Figure S2 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Figure S2 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
Amplification and overexpression of MCM7 in ESCC. A. Amplification of MCM7 in array CGH study. B. Validation of MCM7 amplification by FISH. Left: two MCM7 signals in peripheral blood cells; Middle: two MCM7 signals in ESCC cells; Right: mo…
View article: Supplementary Table 1 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Table 1 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Table 1. NRP1 expression positively correlates with CRT in ESCC
View article: Supplementary Tables from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Supplementary Tables from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Open
Supplementary Table 1. Samples used for whole exome and targeted sequencing. Supplementary Table 2. Clinical information of patients. Supplementary Table 3. 560 Genes screened in the targeted sequencing. Supplementary Table 4. Sequences of…
View article: Supplementary Fig 4 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Supplementary Fig 4 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Open
Supplementary Fig. 4. p53 pathway is dysregulated in ALL.
View article: Figure S2 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Figure S2 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
Amplification and overexpression of MCM7 in ESCC. A. Amplification of MCM7 in array CGH study. B. Validation of MCM7 amplification by FISH. Left: two MCM7 signals in peripheral blood cells; Middle: two MCM7 signals in ESCC cells; Right: mo…
View article: Supplementary Figure 1 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A
Supplementary Figure 1 from Calreticulin Promotes Migration and Invasion of Esophageal Cancer Cells by Upregulating Neuropilin-1 Expression via STAT5A Open
Supplementary Figure 1. Quantitative real-time PCR analysis of CRT expression in ESCC cells transiently transfected with non-silencing siRNA or CRT siRNA. Columns, mean; Bars, SD (n = 3); **, P < 0.01.
View article: Supplementary Fig 2 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Supplementary Fig 2 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Open
Supplementary Fig. 2. Mutations found in the ASXL family of genes.
View article: Supplementary Fig 1 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Supplementary Fig 1 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Open
Supplementary Fig. 1. Mutational spectrum of pediatric ALL.
View article: Data from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Data from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
Purpose: Our aim was to identify frequent genomic aberrations in both esophageal squamous cell carcinoma (ESCC) and esophageal dysplasia and to discover important copy number-driving genes and microRNAs (miRNA) in ESCC.Experiment…
View article: Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
Data from Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma Open
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southeast Asia and Southern China. The pathogenic mechanisms of NPC, particularly those involving epigenetic dysregulation, remain largely elusive, ha…
View article: Figure S3 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization
Figure S3 from Consistent and Differential Genetic Aberrations between Esophageal Dysplasia and Squamous Cell Carcinoma Detected By Array Comparative Genomic Hybridization Open
Venn diagrams comparing differences in expression of our gene/microRNA expression assay and other microarray experiments. A. Comparison of differentially expressed genes in different experiments. B. Comparison of differentially expressed m…