Yi Zhang
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View article: Early cardiac involvement in patients with hyperthyroidism identified by multiparametric cardiovascular magnetic resonance imaging
Early cardiac involvement in patients with hyperthyroidism identified by multiparametric cardiovascular magnetic resonance imaging Open
Background: Hyperthyroidism is reportedly associated with increased cardiovascular risk and heart failure. However, a definite association between hyperthyroidism and cardiomyopathy has not been reported. This study aimed to analyze altera…
View article: Correction: Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China
Correction: Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China Open
[This corrects the article DOI: 10.3389/fmicb.2025.1699705.].
View article: Plasma proteomics identifies proteins and pathways associated with incident epilepsy
Plasma proteomics identifies proteins and pathways associated with incident epilepsy Open
The clinical diagnosis of epilepsy is predominantly based on history taking, morbidity records, and imaging during seizures. The emergence of proteomics has enhanced disease marker detection and potential drug target identification. We per…
View article: Microbiome Profiling of Pretreated Human Breast Milk Using Shotgun Metagenomic Sequencing
Microbiome Profiling of Pretreated Human Breast Milk Using Shotgun Metagenomic Sequencing Open
This study explored the metagenomic sequencing methodology for analyzing the breast milk microbiome and elucidated its composition. Twenty-two breast milk samples were collected from 11 healthy lactating women. By optimizing microbial cell…
View article: Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China
Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China Open
Introduction Ticks are well-known ectoparasites and vectors responsible for transmitting a diverse range of pathogens, including viruses, bacteria, and protozoa, many of which pose substantial risks to public health and livestock. In recen…
View article: Associations between prior COVID-19 infection and health metrics in elderly nursing home residents: A propensity score matched analysis
Associations between prior COVID-19 infection and health metrics in elderly nursing home residents: A propensity score matched analysis Open
With the changes in China’s COVID-19 policies, an increasing number of people have been infected with COVID-19. Elderly residents in nursing homes, due to factors such as advanced age, are considered a vulnerable population. However, there…
View article: Global Research Trends and Focus of Lung Ultrasound: A Bibliometric Analysis
Global Research Trends and Focus of Lung Ultrasound: A Bibliometric Analysis Open
Objective The purpose of this study was to summarize the knowledge structure of pulmonary ultrasound through bibliometric analysis, and to discuss potential research trends and priorities. Methods Publications related to pulmonary ultrasou…
View article: Nrf2 Deficiency Enhances the Immunosuppressive Function of Monocytic Myeloid-derived Suppressor Cells in a PPARγ- Dependent Manner
Nrf2 Deficiency Enhances the Immunosuppressive Function of Monocytic Myeloid-derived Suppressor Cells in a PPARγ- Dependent Manner Open
Background: Myeloid-derived suppressor cells (MDSCs) comprise monocytic MDSCs (M-MDSCs) and granulocytic MDSCs (G-MDSCs), both of which are effective for controlling T cell responses. Although Nrf2 participates in the expansion of MDSCs an…
View article: Association between the COVID-19 pandemic and cardiopulmonary function in acute coronary syndrome patients without SARS-CoV-2 infection
Association between the COVID-19 pandemic and cardiopulmonary function in acute coronary syndrome patients without SARS-CoV-2 infection Open
View article: Pediatric small intestine cavernous lymphangioma detected via wireless capsule endoscopy: a rare case report
Pediatric small intestine cavernous lymphangioma detected via wireless capsule endoscopy: a rare case report Open
Background Cavernous lymphangioma represents a common lesion of the lymphatic system, yet it is rarely encountered in the small intestine. The diagnosis of small intestinal cavernous lymphangioma poses significant clinical challenges. This…
View article: Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases
Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases Open
Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53…
View article: Therapeutic potential of super activated platelet lysate (sPL), and mesenchymal stem cells (MSCs) in a rat model with immune premature ovarian failure
Therapeutic potential of super activated platelet lysate (sPL), and mesenchymal stem cells (MSCs) in a rat model with immune premature ovarian failure Open
Our research shows that sPL, MSCs, and sPL/MSCs all improve the physiological status of ovaries with autoimmune POF, regulate hormone levels and gene expression, increase the number of follicles, and regulate cell apoptosis and growth. In …
View article: Modifiable traits and genetic associations with grey matter volume in mid-to-late adulthood: a population-based study in the UK biobank
Modifiable traits and genetic associations with grey matter volume in mid-to-late adulthood: a population-based study in the UK biobank Open
View article: Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment Open
View article: A retrospective review of nine cases of atypical neurosyphilis
A retrospective review of nine cases of atypical neurosyphilis Open
Background Neurosyphilis may manifest in a form resembling autoimmune encephalitis, primarily characterized by cognitive impairment, psychiatric disorders, and seizures. Brain magnetic resonance imaging typically reveals unilateral or bila…
View article: An Innovative Strategy for Untargeted Mass Spectrometry Data Analysis: Rapid Chemical Profiling of the Medicinal Plant Terminalia chebula Using Ultra-High-Performance Liquid Chromatography Coupled with Q/TOF Mass Spectrometry–Key Ion Diagnostics–Neutral Loss Filtering
An Innovative Strategy for Untargeted Mass Spectrometry Data Analysis: Rapid Chemical Profiling of the Medicinal Plant Terminalia chebula Using Ultra-High-Performance Liquid Chromatography Coupled with Q/TOF Mass Spectrometry–Key Ion Diagnostics–Neutral Loss Filtering Open
Structural characterization of natural products in complex herbal extracts remains a major challenge in phytochemical analysis. In this study, we present a novel post-acquisition data-processing strategy—key ion diagnostics–neutral loss fi…
View article: Intravenous Immunoglobulin Non-Responsive Kawasaki Disease Characterized by Cholestatic Jaundice
Intravenous Immunoglobulin Non-Responsive Kawasaki Disease Characterized by Cholestatic Jaundice Open
View article: The role of the TARDBP gene in osteonecrosis of the femoral head: Bioinformatics analysis and mechanistic exploration
The role of the TARDBP gene in osteonecrosis of the femoral head: Bioinformatics analysis and mechanistic exploration Open
Osteonecrosis of the femoral head (ONFH) is a condition caused by venous stasis, impaired arterial blood flow, or destruction of the femoral head, often resulting in the localized death of bone cells and bone marrow components, leading to …
View article: Global research trends and focus of Lung Ultrasound: A Bibliometric Analysis
Global research trends and focus of Lung Ultrasound: A Bibliometric Analysis Open
Object: The purpose of this study was to summarize the knowledge structure of pulmonary ultrasound through bibliometric analysis, and to discuss potential research trends and priorities. Methods: Publications related to pulmonary ultrasoun…
View article: Transnasal PLGA Nanoparticles with Terpene Permeation Enhancers: Membrane Remodeling and Tight Junction Modulation for Enhanced Brain Drug Delivery
Transnasal PLGA Nanoparticles with Terpene Permeation Enhancers: Membrane Remodeling and Tight Junction Modulation for Enhanced Brain Drug Delivery Open
Nasal nanodrug delivery has gained prominence as a non-invasive method for administering therapeutic agents to the brain. However, the limited nasal cavity volume and the low drug loading capacity of nanoparticles contribute to a reduced a…
View article: Integrated metabolite profiling and transcriptome analysis identify candidate genes involved in diterpenoid alkaloid biosynthesis in Aconitum pendulum
Integrated metabolite profiling and transcriptome analysis identify candidate genes involved in diterpenoid alkaloid biosynthesis in Aconitum pendulum Open
Introduction Aconitum pendulum is a well-known Tibetan medicine that possesses abundant diterpenoid alkaloids (DAs) with high medicinal value. However, due to the complicated structures of DAs and the associated challenges in vitro synthes…
View article: Study of factors influencing the insertion failure of single balloon enteroscopy-assisted ERCP treatment after bilioenteric Roux-en-Y anastomosis
Study of factors influencing the insertion failure of single balloon enteroscopy-assisted ERCP treatment after bilioenteric Roux-en-Y anastomosis Open
SBE-assisted ERCP is safe and effective in patients after bilioenteric Roux-en-Y anastomosis. The severity of afferent loop twisting and Rou-Y anastomosis shape were risk factors for endoscopic insertion failure. Surgeons should take into …
View article: Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration Open
View article: The High Expression of PD-1 Defines A Subpopulation of Tfh Cells Responding to COVID-19 Vaccine in Humans
The High Expression of PD-1 Defines A Subpopulation of Tfh Cells Responding to COVID-19 Vaccine in Humans Open
Inactivated coronavirus disease 2019 (COVID-19) vaccines and receptor binding domain subunit (RBD-subunit) booster vaccination can induce effective humoral immune response. CD4+ T helper cells are essential in helping B cells and antibody …
View article: Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery
Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery Open
Identifying the active natural compounds remains a challenge for drug discovery, and new algorithms need to be developed to predict active ingredients from complex natural products. Here, we proposed Meta-DEP, a Meta-paths-based Drug Effic…
View article: Comparative efficacy and safety of febuxostat and allopurinol in chronic kidney disease stage 3–5 patients with asymptomatic hyperuricemia: a network meta-analysis
Comparative efficacy and safety of febuxostat and allopurinol in chronic kidney disease stage 3–5 patients with asymptomatic hyperuricemia: a network meta-analysis Open
This analysis provides robust evidence that febuxostat might offers greater improvements in kidney function and uric acid levels compared to allopurinol or placebo in asymptomatic hyperuricemia with CKD stage 3-5 patients, without compromi…
View article: The triglyceride-glucose index and acute kidney injury risk in critically ill patients with coronary artery disease
The triglyceride-glucose index and acute kidney injury risk in critically ill patients with coronary artery disease Open
In summary, the TyG index emerged as a reliable predictor for the occurrence of AKI in CAD patients during ICU stay. Furthermore, it is also anticipated to serve as a valuable indicator for non-diabetic patients in predicting the incidence…
View article: REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling
REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling Open
Taken together, our data indicated that increased expression of REG3A in peritumoral acinar cells acts as a specific event to indicate PDAC progression, and verified EGFR as a possible target of REG3A, providing mechanistic insights into t…
View article: Transcriptomics reveals preterm birth risk: identification and validation of key genes in monocytes
Transcriptomics reveals preterm birth risk: identification and validation of key genes in monocytes Open
View article: Affinity Ultrafiltration Mass Spectrometry for Screening Active Ingredients in Traditional Chinese Medicine: A Review of the Past Decade (2014–2024)
Affinity Ultrafiltration Mass Spectrometry for Screening Active Ingredients in Traditional Chinese Medicine: A Review of the Past Decade (2014–2024) Open
Discovering targets in natural products is a critical and challenging task in new drug development. Rapid and efficient screening of active ingredients from complex systems like traditional Chinese medicine (TCM) is now crucial in drug res…