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View article: Key Technologies of Synthetic Biology in Industrial Microbiology
Key Technologies of Synthetic Biology in Industrial Microbiology Open
Industrial microorganisms have a wide range of applications in biomanufacturing, energy production, environmental protectionpharmaceutical development, etc. Synthetic biology has revolutionised the field of industrial microorganisms by des…
View article: BK Polyomavirus Prevalence in Renal Diseases: Associations with Immunosuppressants and Lymphocyte Subsets
BK Polyomavirus Prevalence in Renal Diseases: Associations with Immunosuppressants and Lymphocyte Subsets Open
These findings support monitoring BKV-DNA in high-risk RD patients to guide immunosuppressant use and mitigate renal injury. Future long-term follow-up and multicenter large-scale cohort studies are necessary to further clarify the role of…
View article: Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8
Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8 Open
Seven previously undescribed polycyclic meroterpenoids talarines K–Q ( 1 – 7 ), along with five known ones ( 8 – 12 ), were isolated from desert-derived fungi Talaromyces sp. HMT-8. The structure of the novel compounds were elucidated usin…
View article: Accuracy Analysis and Synthesis of Planar Mechanism for Antenna Based on Screw Theory and Geometric Coordination
Accuracy Analysis and Synthesis of Planar Mechanism for Antenna Based on Screw Theory and Geometric Coordination Open
To address the deployment accuracy issues of multi-frequency band reflector antennas, this study takes a hexagonal prism modular deployable antenna as an example and proposes an accuracy design method. This paper proposes a screw-theory-ba…
View article: Insights to Micropsoridia Nosema bombycis congenital infection and host immune responses in the embryo and larva stages of silkworms
Insights to Micropsoridia Nosema bombycis congenital infection and host immune responses in the embryo and larva stages of silkworms Open
Microsporidia are a group of intracellular and unicellular eukaryotic parasites, which can nearly infect all animals, including human beings. As the first identified microsporidia, Nosema bombycis is a world-wide threat for silkworm eggs p…
View article: Analysis of genotypic distribution and rare variants of patients with α/β-thalassemia screened in one hospital in Beijing, China
Analysis of genotypic distribution and rare variants of patients with α/β-thalassemia screened in one hospital in Beijing, China Open
The genotype distribution of thalassemia in a general hospital in Beijing is complex and heterogeneous. The novel variants in HBA2 and HBB are likely to underlie α/β-thalassemia in these patients.
View article: TemporalBench: Benchmarking Fine-grained Temporal Understanding for Multimodal Video Models
TemporalBench: Benchmarking Fine-grained Temporal Understanding for Multimodal Video Models Open
Understanding fine-grained temporal dynamics is crucial for multimodal video comprehension and generation. Due to the lack of fine-grained temporal annotations, existing video benchmarks mostly resemble static image benchmarks and are inco…
View article: Case report: A rare heterozygous Hb CS with heterozygous HbE in a family with thalassemia in China
Case report: A rare heterozygous Hb CS with heterozygous HbE in a family with thalassemia in China Open
Thalassemia is a hemoglobin disease characterized by reduced or complete absence of the production of the α/β globin gene. Currently, the detection of β-thalassemia carriers is based on differences in blood cell parameters. However, β-thal…
View article: Serum Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) as a Potential Biomarker for Diagnosis of Hepatocellular Carcinoma
Serum Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) as a Potential Biomarker for Diagnosis of Hepatocellular Carcinoma Open
Our study demonstrated that serum AKR1B10 is a promising biomarker for HCC, and when used in combination with AFP can significantly improve the detection rate of HCC.
View article: Plasminogen Activator Inhibitor-1 4G/5G (rs1799889) Polymorphism in Chinese Patients with Diabetes Mellitus and Hypertension
Plasminogen Activator Inhibitor-1 4G/5G (rs1799889) Polymorphism in Chinese Patients with Diabetes Mellitus and Hypertension Open
The RT-PCR method can accurately identify the PAI-1 4G/5G genotype in different individuals. The PAI-1 4G/5G polymorphism may not be associated with genetic susceptibility to DM, HTN and DM+HTN, but differences in clinical characteristics …
View article: Cytomegalovirus antigen-specific T cell immune responses in patients with autoimmune diseases under different cytomegalovirus infection status
Cytomegalovirus antigen-specific T cell immune responses in patients with autoimmune diseases under different cytomegalovirus infection status Open
To the Editor: Patients with autoimmune diseases have increased risk of active cytomegalovirus (CMV) infection due to immune dysfunction or the application of glucocorticoid and immunosuppressants.[1] Cui et al[2] found that compared with …
View article: CYSLTR1 rs320995 (T927C) and GSDMB rs7216389 (G1199A) Gene Polymorphisms in Asthma and Allergic Rhinitis: A Proof-of-Concept Study
CYSLTR1 rs320995 (T927C) and GSDMB rs7216389 (G1199A) Gene Polymorphisms in Asthma and Allergic Rhinitis: A Proof-of-Concept Study Open
We have established a reliable TaqMan-MGB qPCR method for the detection of CYSLTR1 rs320995 and GSDMB rs7216389 polymorphisms. Moreover, the CYSLTR1 rs320995 polymorphism may be associated with genetic susceptibility of Chinese female pati…
View article: Tumor Necrosis Factor Alpha -308G/A Gene Polymorphisms Combined with Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Predicts the Efficacy and Safety of Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis Arthritis
Tumor Necrosis Factor Alpha -308G/A Gene Polymorphisms Combined with Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Predicts the Efficacy and Safety of Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis Arthritis Open
Background: TNF-α has been reported to be closely associated with autoimmune inflammatory diseases. This study aims to investigate the role of TNF-α -308(rs1800629) G/A gene polymorphisms as well as neutrophil-to-lymphocyte ratio (NLR) and…
View article: Prevalence and Genotype Distribution of Human Papillomavirus Among Healthy Females in Beijing, China, 2016–2019
Prevalence and Genotype Distribution of Human Papillomavirus Among Healthy Females in Beijing, China, 2016–2019 Open
Our findings could serve as potential reference for better understanding of the epidemiological characteristics of HPV infection in Beijing.
View article: Copy Number Assessment of SMN1 Based on Real-Time PCR With High-Resolution Melting: Fast and Highly Reliable Testing
Copy Number Assessment of SMN1 Based on Real-Time PCR With High-Resolution Melting: Fast and Highly Reliable Testing Open
Background: Spinal muscular atrophy (SMA) is a common neuromuscular disorder, caused by absence of both copies of the survival motor neuron 1 (SMN1) gene. Population-wide SMA screening to quantify copy number of SMN1 is recommended by mult…
View article: Evaluating the clinical performance of a novel dual-target stool DNA test for colorectal cancer detection
Evaluating the clinical performance of a novel dual-target stool DNA test for colorectal cancer detection Open
BACKGROUND AND AIMS Methylation-based stool DNA test showed a promising application for colorectal cancer (CRC) detection. This study aimed to evaluate the performance of a novel dual-target stool DNA test (DT-sDNA), composed of SDC2 and T…
View article: Cytomegalovirus antigen-specific T Cell immune response in patients with autoimmune diseases under different cytomegalovirus infection status
Cytomegalovirus antigen-specific T Cell immune response in patients with autoimmune diseases under different cytomegalovirus infection status Open
Background: T-cell immunity is important for the control of cytomegalovirus (CMV) infection. The frequency of IFN-γ secreting T cells after stimulation with CMV-specific protein-1 (IE-1) and phosphoprotein 65 (pp65) antigen can help predic…
View article: HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population
HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population Open
HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, …
View article: Alteration of glucocorticoid receptors and exacerbation of inflammation during lytic cytomegalovirus infection in <scp>THP</scp>‐1 cells
Alteration of glucocorticoid receptors and exacerbation of inflammation during lytic cytomegalovirus infection in <span>THP</span>‐1 cells Open
Cytomegalovirus ( CMV ) infection is associated with glucocorticoid resistance in ulcerative colitis (UC) and may exacerbate the disease course. However, the underlying pathogenicity remains unclear. The aim of this study was to explore po…
View article: Efficient replication of blood‐borne hepatitis C virus in human fetal liver stem cells
Efficient replication of blood‐borne hepatitis C virus in human fetal liver stem cells Open
The development of pathogenic mechanisms, specific antiviral treatments and preventive vaccines for hepatitis C virus (HCV) infection has been limited due to lack of cell culture models that can naturally imitate the entire HCV life cycle.…
View article: Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy
Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy Open
Together, these animal model data indicate that IL-12 shows a better curative effect than PTX + CDDP doublet chemotherapy.
View article: Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer Open
NSUN2 is a RNA methyltransferase that has been shown to be implicated in development of human cancer. However, the functional role of NSUN2, mechanism of NSUN2 overexpression and its association with clinicopathologic features in breast ca…
View article: Additional file 3: Figure S3. of Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy
Additional file 3: Figure S3. of Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy Open
Spleens were enlarged after IL-12 treatment. (A) The spleen-size was calculated. The spleen-sizes increased significantly after IL-12 or PTX + CDDP + IL-12 treatment and were slightly reduced after PTX + CDDP treatment compared to the PTX …
View article: Additional file 1: Figure S1. of Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy
Additional file 1: Figure S1. of Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy Open
Analysis of lung tumor nodes and tumor lung tissues weight in the four treatment groups. (A) The LLC tumor nodes and lung tissues were photographed. The visible tumor nodes were counted, and the final lung tumor tissues were photographed a…