Feng Yang
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View article: A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles
A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles Open
To explore the molecular mechanism of hair follicle apoptosis in the goat hair cycle, single-cell transcriptome sequencing was performed on 8,214 hair follicle cells in the Anagen period, Catagen period, and Telogen period. We identified n…
View article: TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report
TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report Open
Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male w…
View article: m276-SL-PBD eradicates tumors and instigates long-lasting tumor-free survival in Merkel cell carcinoma preclinical models
m276-SL-PBD eradicates tumors and instigates long-lasting tumor-free survival in Merkel cell carcinoma preclinical models Open
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine carcinoma, and immune checkpoint inhibitors (ICIs) are the only approved therapy; nonetheless, resistance is notable and there is a critical need for novel effective thera…
View article: Flavonoids from <i>Polypodium hastatum</i> as neuroprotective agents attenuate cerebral ischemia/reperfusion injury <i>in vitro</i> and <i>in vivo</i> via activating Nrf2
Flavonoids from <i>Polypodium hastatum</i> as neuroprotective agents attenuate cerebral ischemia/reperfusion injury <i>in vitro</i> and <i>in vivo</i> via activating Nrf2 Open
This investigation could provide lead compounds for the discovery of novel Nrf2 activators targeting ischemia/reperfusion injury.
View article: Tiliroside from Potentilla chinensis attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2
Tiliroside from Potentilla chinensis attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2 Open
Diabetic nephropathy (DN) is one of the severe microvascular complications of diabetes mellitus and it was proved activation of nuclear factor erythroid 2-related factor 2 (Nrf2) could attenuate DN. To find Nrf2 activators, we explored til…
View article: Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goats
Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goats Open
The problem of human hair loss has caused widespread concern, however, such research is difficult because the periodicity is not obvious and the deeper levels knowledge of dermal papilla (DP) stem cells' differentiation are limited. Here, …
View article: Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose
Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose Open
Diabetic nephropathy (DN) is one of the severe microvascular complications of diabetes mellitus. Oxidative stress resulting from aberrant metabolism of glucose mediates renal inflammation and fibrosis in the progression of DN. Nuclear fact…
View article: Inhibition of Endoplasmic Reticulum Stress by 4-Phenyl Butyric Acid Presents Therapeutic Effects on Periodontitis: Experimental Studies In Vitro and in Rats
Inhibition of Endoplasmic Reticulum Stress by 4-Phenyl Butyric Acid Presents Therapeutic Effects on Periodontitis: Experimental Studies In Vitro and in Rats Open
This study investigated the probable mechanisms of endoplasmic reticulum (ER) stress involved in periodontitis in vitro and in vivo. We isolated periodontal ligament stem cells from periodontitis patients and healthy controls (P-PDLSCs and…
View article: miR-325-3p Promotes the Proliferation, Invasion, and EMT of Breast Cancer Cells by Directly Targeting S100A2
miR-325-3p Promotes the Proliferation, Invasion, and EMT of Breast Cancer Cells by Directly Targeting S100A2 Open
This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer (BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell lines, and the expression…
View article: <p><em>PTHLH</em> Predicts the Prognosis of Patients with Oral Leukoplakia</p>
<em>PTHLH</em> Predicts the Prognosis of Patients with Oral Leukoplakia Open
Our data suggest that either PTHLH or PTHrP plays a key role in the malignant transformation of oral leukoplakia and might be a reliable biomarker for predicting the carcinogenesis of oral leukoplakia.
View article: SATB1 siRNA-encapsulated immunoliposomes conjugated with CD44 antibodies target and eliminate gastric cancer-initiating cells
SATB1 siRNA-encapsulated immunoliposomes conjugated with CD44 antibodies target and eliminate gastric cancer-initiating cells Open
As far as we know, our report is the first research that indicated the promotion of siRNA delivery via nanoparticles to gastric CICs and achievement of superior therapeutic effect against gastric CICs by utilization of CD44 antibody. There…
View article: Clinical relevance of the tissue protease KLK4 for triple-negative breast cancer
Clinical relevance of the tissue protease KLK4 for triple-negative breast cancer Open
The subgroup of triple-negative breast cancer (TNBC) is characterized by aggressive behavior and resistance against endocrine therapy. Aim of the dissertation was to investigate whether the protease KLK4, a member of the tissue kallikrein …
View article: Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course Open
The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, an…