Yinmo Yang
YOU?
Author Swipe
View article: Research progress of pancreatic cancer-associated neutrophils
Research progress of pancreatic cancer-associated neutrophils Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor of the digestive tract, with a five-year survival rate of approximately 12%. Liver metastasis is a key factor affecting the long-term survival rate of PDAC pati…
View article: Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer
Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound metabolic reprogramming, with polyamine metabolism emerging as a key driver of tumor progression and immune evasion. However, its comprehensive role and clinical significance in PDA…
View article: Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer
Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer Open
Immunoglobulin (Ig) is an important part of the immune system, which is mainly produced by B cells to recognize and kill pathogens. In recent years, the concept of cancer-derived immunoglobulin (cIg) has been proposed. cIg is a special for…
View article: Organoid in droplet: Production of uniform pancreatic cancer organoids from single cells
Organoid in droplet: Production of uniform pancreatic cancer organoids from single cells Open
Cancer organoids have improved our understanding of recapitulating the histology, genotypes, and drug response of patient tumors for personalized medicine. However, the existing cancer organoids are typically grown in animal-derived matric…
View article: The functional extracellular vesicles target tumor microenvironment for gastrointestinal malignancies therapy
The functional extracellular vesicles target tumor microenvironment for gastrointestinal malignancies therapy Open
The tumor microenvironment (TME) represents a complex, heterogeneous ecosystem that significantly influences the progression of gastrointestinal (GI) cancers, comprising diverse cellular and non-cellular components. Although chemotherapeut…
View article: Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition)
Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition) Open
Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibito…
View article: Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution
Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution Open
Metabolic reprogramming provides tumors with an energy source and biofuel to support their survival in the malignant microenvironment. Extensive research into the intrinsic oncogenic mechanisms of the tumor microenvironment (TME) has estab…
View article: Recent advances in the treatment of pancreatic cancer
Recent advances in the treatment of pancreatic cancer Open
Pancreatic cancer (PC) is one of the most aggressive gastrointestinal malignancies, characterized by rapid progression and early onset of metastasis, leading to a dismal prognosis for patients. In the recent past, substantial progress has …
View article: Stem cell-like circulating tumor cells identified by Pep@MNP and their clinical significance in pancreatic cancer metastasis
Stem cell-like circulating tumor cells identified by Pep@MNP and their clinical significance in pancreatic cancer metastasis Open
Objective The circulating tumor cells (CTCs) could be captured by the peptide functionalized magnetic nanoparticles (Pep@MNP) detection system in pancreatic ductal adenocarcinoma (PDAC). CTCs and the CXCR4 expression were detected to explo…
View article: Laminin γ-2 (LAMC2) promotes the proliferation and invasion of pancreatic cancer cells by regulating PI3K/Akt signaling
Laminin γ-2 (LAMC2) promotes the proliferation and invasion of pancreatic cancer cells by regulating PI3K/Akt signaling Open
Background: Pancreatic ductal adenocarcinoma (PDAC) poses a serious threat to human health with high mortality and poor prognosis, and there is an urgent need to explore the pathogenesis of PDAC in order to search for new therapeutic targe…
View article: Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1
Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1 Open
Background: Cell competition is an important feature in pancreatic cancer (PC) progression, but the underlying mechanism remains elusive. This study aims to explore the role of exosomes derived from normal pancreatic ductal epithelial cell…
View article: Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study
Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study Open
Objectives The effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after…
View article: The effect of minimally invasive or open radical antegrade modular pancreatosplenectomy on pancreatic cancer: A multicenter randomized clinical trial protocol
The effect of minimally invasive or open radical antegrade modular pancreatosplenectomy on pancreatic cancer: A multicenter randomized clinical trial protocol Open
Background Radical antegrade modular pancreatosplenectomy (RAMPS) has been proven to improve R0 resection and lymph harvest in treating patients with distal pancreatic cancer. The development of minimally invasive surgery has advantages in…
View article: Safety evaluation of early drain removal following pancreatic resections: Meta-analysis and single-center retrospective cohort study
Safety evaluation of early drain removal following pancreatic resections: Meta-analysis and single-center retrospective cohort study Open
Background:No consensus was reached with regard to whether to place prophylactic intraperitoneal drainage, when to remove drainages after pancreatic resections.The meta-analysis and single-center retrospective cohort study were designed to…
View article: Hypoxic pancreatic cancer derived exosomal MiR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression
Hypoxic pancreatic cancer derived exosomal MiR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression Open
Background: Most patients with pancreatic ductal adenocarcinoma (PDAC) have vascular invasion and metastasis, leading to low surgical resection rate and dismal prognosis.Tumor angiogenesis is closely related to vascular invasion and metast…
View article: Construction of immune related prognostic model for pancreatic ductal adenocarcinoma based on single cell RNA-seq analysis
Construction of immune related prognostic model for pancreatic ductal adenocarcinoma based on single cell RNA-seq analysis Open
There are no reliable biomarkers for early diagnosis and prognosis evaluation in pancreatic ductal adenocarcinoma (PDAC). Single cell RNA-seq (scRNA-seq) revealed tumor microenvironment heterogeneity in PDAC. This study aimed to construct …
View article: Predictive Model of Early Death of Resectable Pancreatic Ductal Adenocarcinoma After Curative Resection: A SEER-Based Study
Predictive Model of Early Death of Resectable Pancreatic Ductal Adenocarcinoma After Curative Resection: A SEER-Based Study Open
Objective This study aims to determine the factors that predict early death and establish a predictive model for early death by analyzing clinical characteristics of patients with resectable pancreatic ductal adenocarcinoma (R-PDAC) who di…
View article: Prophylactic Ureteral Catheter Placement Appears to Reduce Intraoperative Ureteric Injury During Resection of Primary Retroperitoneal Liposarcoma
Prophylactic Ureteral Catheter Placement Appears to Reduce Intraoperative Ureteric Injury During Resection of Primary Retroperitoneal Liposarcoma Open
Background: Prophylactic ureteral catheters placement (PUCP) was advocated as an effective strategy for decreasing ureteral morbidities in colorectal surgeries. However, whether it should be routinely used prior to primary retroperitoneal …
View article: Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target
Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target Open
Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. T…
View article: The Chinese guidelines for neoadjuvant therapy of pancreatic cancer (2020)
The Chinese guidelines for neoadjuvant therapy of pancreatic cancer (2020) Open
Aiming to keep pace with the renewal of international guidelines and refine the domestic treatment system of pancreatic cancer, the Chinese Pancreatic Surgery Association, Chinese Medical Association and Pancreatic Disease Committee of Chi…
View article: Association of Abdominal Incision Length With Gastrointestinal Function Recovery Post-operatively: A Multicenter Registry System-Based Retrospective Cohort Study
Association of Abdominal Incision Length With Gastrointestinal Function Recovery Post-operatively: A Multicenter Registry System-Based Retrospective Cohort Study Open
Objective: To evaluate the influence of the abdominal incision length on the gastrointestinal function recovery post-operatively. Background: Gut motility recovers more quickly after the minimally invasive laparoscopic surgery compared tha…
View article: Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma: potential diagnostic and prognostic significance in clinical practice
Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma: potential diagnostic and prognostic significance in clinical practice Open
Circulating tumor cells (CTCs); Pancreatic ductal adenocarcinoma (PDAC); Epithelial to mesenchymal transition (EMT); human equilibrative nucleoside transporter-1 (hENT-1).
View article: Real-world study of surgical treatment of pancreatic cancer in China: annual report of China Pancreas Data Center (2016–2020)
Real-world study of surgical treatment of pancreatic cancer in China: annual report of China Pancreas Data Center (2016–2020) Open
Objective: In 2015, the Chinese Pancreatic Association of the Chinese Society of Surgery of the Chinese Medical Association launched a national multicenter online system for registration of surgical treatment of pancreatic cancer in China,…
View article: Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)
Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021) Open
The incidence of pancreatic cancer has been rising worldwide, and its clinical diagnosis and treatment remain a great challenge. To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent …
View article: Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis
Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis Open
Introduction Prophylactic intra-peritoneal drainage has been considered to be an effective measure to reduce postoperative complications after pancreatectomy. However, routinely placed drainage during abdominal surgery may be unnecessary o…
View article: A modified alternative fistula risk score (a-FRS) obtained from the computed tomography enhancement pattern of the pancreatic parenchyma predicts pancreatic fistula after pancreatoduodenectomy
A modified alternative fistula risk score (a-FRS) obtained from the computed tomography enhancement pattern of the pancreatic parenchyma predicts pancreatic fistula after pancreatoduodenectomy Open
The modified a-FRS is an objective and preoperative model for predicting the occurrence of CR-POPF after PD.