Yaokai Chen
YOU?
Author Swipe
View article: Association Between the Systemic Immune-Inflammation Index and 24-week Outcomes in Patients with HIV-Associated Cryptococcal Meningitis: Secondary Analysis of a Prospective Multicenter Cohort Study
Association Between the Systemic Immune-Inflammation Index and 24-week Outcomes in Patients with HIV-Associated Cryptococcal Meningitis: Secondary Analysis of a Prospective Multicenter Cohort Study Open
View article: Large-scale evaluation of HIV-1 DNA drug resistance testing as a robust tool for clinical decision-making: A nationwide study in China
Large-scale evaluation of HIV-1 DNA drug resistance testing as a robust tool for clinical decision-making: A nationwide study in China Open
View article: Efficacy of raltegravir in achieving virological suppression at delivery in HIV-positive pregnant women: a systematic review and meta-analysis
Efficacy of raltegravir in achieving virological suppression at delivery in HIV-positive pregnant women: a systematic review and meta-analysis Open
Background The world’s first HIV integrase inhibitor, raltegravir (RAL), has been widely used for the treatment of HIV infection over the past 15 years, and continues benefiting people living with HIV (PLWH) today due to its efficient viro…
View article: Cognitive and mental health significantly contribute to disability in people ageing with HIV in Asia: an observational case‐control study
Cognitive and mental health significantly contribute to disability in people ageing with HIV in Asia: an observational case‐control study Open
Introduction Disability disproportionally impacts people living with HIV (PLWH). The burden and determinants of disability among PLWH in Asia have not been well studied. Methods We conducted a multi‐country observational cross‐sectional st…
View article: Immediate and delayed switches to tenofovir DF-containing, ainuovirine-based antiretroviral regimen: the SPRINT extensional study
Immediate and delayed switches to tenofovir DF-containing, ainuovirine-based antiretroviral regimen: the SPRINT extensional study Open
Chinese Clinical Trial Register number, ChiCTR2100051605.
View article: Expert consensus on the clinical management of HIV late presentation
Expert consensus on the clinical management of HIV late presentation Open
With the advancement of combination antiretroviral therapy (cART), the global number of new human immunodeficiency virus (HIV) infections and HIV-related mortality has significantly declined. However, the high proportion of “late presentat…
View article: A national, multicenter, retrospective study of human immunodeficiency virus infection-associated lymphoma in China
A national, multicenter, retrospective study of human immunodeficiency virus infection-associated lymphoma in China Open
View article: Risk-Taking Behaviors and Adherence to HIV Pre-Exposure Prophylaxis in Users of Geosocial Networking Apps: Real-World, Multicenter Study
Risk-Taking Behaviors and Adherence to HIV Pre-Exposure Prophylaxis in Users of Geosocial Networking Apps: Real-World, Multicenter Study Open
BACKGROUND: Over half of men who have sex with men (MSM) use geosocial networking (GSN) apps to encounter sex partners. GSN apps' users have become a unique large subpopulation among MSM for interventions concerning HIV prevention and cont…
View article: HIV and other STIs self-testing to reduce risk compensation among men who have sex with men who use oral pre-exposure prophylaxis in China: protocol for a randomised waitlist-controlled trial
HIV and other STIs self-testing to reduce risk compensation among men who have sex with men who use oral pre-exposure prophylaxis in China: protocol for a randomised waitlist-controlled trial Open
INTRODUCTION: Pre-exposure prophylaxis (PrEP) reduces the risk of HIV infection among men who have sex with men by up to 99%. However, in real-world settings, PrEP users may exhibit risk compensation after uptake of PrEP, including more co…
View article: Correction: Risk-Taking Behaviors and Adherence to HIV Pre-Exposure Prophylaxis in Users of Geosocial Networking Apps: Real-World, Multicenter Study
Correction: Risk-Taking Behaviors and Adherence to HIV Pre-Exposure Prophylaxis in Users of Geosocial Networking Apps: Real-World, Multicenter Study Open
[This corrects the article DOI: 10.2196/22388.].
View article: Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin
Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin Open
Funding for this study was provided by the National Key Research and Development Program of China (Grant no. 2021YFA1300901).
View article: Double-Dose Dolutegravir and Lamivudine Versus Efavirenz-Based Antiretroviral Therapy for Patients Coinfected with HIV and Tuberculosis: A Multicentre Open-Label, Randomised Trial
Double-Dose Dolutegravir and Lamivudine Versus Efavirenz-Based Antiretroviral Therapy for Patients Coinfected with HIV and Tuberculosis: A Multicentre Open-Label, Randomised Trial Open
View article: Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China
Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China Open
BACKGROUND: Routine HIV testing accompanied with pre-exposure prophylaxis (PrEP) requires innovative support in a real-world setting. OBJECTIVE: This study aimed to determine the usage of HIV self-testing (HIVST) kits and their secondary d…
View article: Preference for daily versus on‐demand pre‐exposure prophylaxis for HIV and correlates among men who have sex with men: the China Real‐world Oral PrEP Demonstration study
Preference for daily versus on‐demand pre‐exposure prophylaxis for HIV and correlates among men who have sex with men: the China Real‐world Oral PrEP Demonstration study Open
INTRODUCTION: This study explores the preference for daily versus on-demand pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in developing countries when both regimens are available. METHODS: From 11 December 2018 to 1…
View article: Association of HIV Preexposure Prophylaxis Use With HIV Incidence Among Men Who Have Sex With Men in China
Association of HIV Preexposure Prophylaxis Use With HIV Incidence Among Men Who Have Sex With Men in China Open
Importance: Evidence on HIV preexposure prophylaxis (PrEP) among Chinese men who have sex with men (MSM) is critical to guide its large-scale implementation in low- and middle-income countries. Objective: To evaluate incident HIV infection…
View article: Dehydroleucodine exerts an antiproliferative effect on human Burkitt’s lymphoma Daudi cells via SLC7A11-mediated ferroptosis
Dehydroleucodine exerts an antiproliferative effect on human Burkitt’s lymphoma Daudi cells via SLC7A11-mediated ferroptosis Open
Background Burkitt’s lymphoma (BL) is a rare, highly aggressive B-cell non-Hodgkin’s lymphoma known for rapid proliferation. While most patients respond well to intensive chemotherapy, those who are older, have comorbidities, or develop th…
View article: P-selectin glycoprotein ligand-1 and cardiovascular diseases: from a general perspective to an HIV infection context
P-selectin glycoprotein ligand-1 and cardiovascular diseases: from a general perspective to an HIV infection context Open
Globally, cardiovascular diseases (CVDs) are a leading cause of death as they are responsible for the loss of at least 17 million lives annually. It has been established that the pathogenesis of CVDs is strongly associated both with inflam…
View article: P-588. Improved Lipid Profile in Virologically Suppressed People with <i>HIV-1</i> Switching to Tenofovir DF-Containing, Ainuovirine-Based Compared to Tenofovir Alafenamide-Containing, Boosted Elvitegravir-Based Antiretroviral Regimen: the Secondary Analyses of 48-Week Results of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Study
P-588. Improved Lipid Profile in Virologically Suppressed People with <i>HIV-1</i> Switching to Tenofovir DF-Containing, Ainuovirine-Based Compared to Tenofovir Alafenamide-Containing, Boosted Elvitegravir-Based Antiretroviral Regimen: the Secondary Analyses of 48-Week Results of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Study Open
Background ACC008 is a tenofovir DF (TDF) containing, ainuovirine (ANV), a new-generation NNRTI, based fixed-dose combination (FDC). This FDC has shown noninferior virological efficacy but improved lipid profile compared to tenofovir alafe…
View article: P-587. Durable Virological Suppression, Reduced Body Weight, and Improved Serum Cholesterol after Switch to Tenofovir DF-Containing, Ainuovirine-Based Antiretroviral Regimen in People with <i>HIV-1</i>: the 96-Week Results of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Extensional Study
P-587. Durable Virological Suppression, Reduced Body Weight, and Improved Serum Cholesterol after Switch to Tenofovir DF-Containing, Ainuovirine-Based Antiretroviral Regimen in People with <i>HIV-1</i>: the 96-Week Results of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Extensional Study Open
Background The SPRINT trial was a multi-center, randomized, double-blind, active-controlled study in virologically suppressed people with HIV-1 (PWHs) switching from efavirenz-based antiretroviral (ARV) regimen. This study compared the eff…
View article: P-589. Cholesterol Control in Virologically Suppressed People with <i>HIV-1</i> Switching to Tenofovir DF-containing, Ainuovirine-Based Compared to Tenofovir Alafenamide-Containing, Boosted Elvitegravir-Based Antiretroviral Regimen: Hypercholesterolemic Subgroup Analyses of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Study
P-589. Cholesterol Control in Virologically Suppressed People with <i>HIV-1</i> Switching to Tenofovir DF-containing, Ainuovirine-Based Compared to Tenofovir Alafenamide-Containing, Boosted Elvitegravir-Based Antiretroviral Regimen: Hypercholesterolemic Subgroup Analyses of the SPRINT Trial, a Randomized, Active-Controlled Phase 3 Study Open
Background In the SPRINT trial, virologically suppressed people with HIV-1 (PWHs) switched to tenofovir DF (TDF) containing, ainuovirine (ANV, ACC008) based or tenofovir alafenamide (TAF) containing, boosted elvitegravir (EVG/c, comparator…
View article: Amphotericin B Colloidal Dispersion is Efficacious and Safe for the Management of Talaromycosis in HIV-Infected Patients: Results of a Retrospective Cohort Study in China
Amphotericin B Colloidal Dispersion is Efficacious and Safe for the Management of Talaromycosis in HIV-Infected Patients: Results of a Retrospective Cohort Study in China Open
ABCD has a clinical efficacy comparable to AmB-D, with higher symptom remission rate, lower nephrotoxicity, and lower bone marrow suppression, indicating that ABCD may be an appropriate alternative option for the clinical management of tal…
View article: Antiretroviral Therapy combined with Shenling Guben Granules for the treatment of HIV infection with immune reconstitution deficiency: a randomized, double-blind, placebo-controlled study
Antiretroviral Therapy combined with Shenling Guben Granules for the treatment of HIV infection with immune reconstitution deficiency: a randomized, double-blind, placebo-controlled study Open
Background: Even with long-term complete suppression of the virus through antiretroviral therapy (ART), people infected with HIV cannot attain optimal immune reconstitution. This phenomenon is called immune reconstitution deficiency, there…
View article: Epidemiological changes of scarlet fever before, during and after the COVID-19 pandemic in Chongqing, China: a 19-year surveillance and prediction study
Epidemiological changes of scarlet fever before, during and after the COVID-19 pandemic in Chongqing, China: a 19-year surveillance and prediction study Open
View article: Performance of metagenomic Next-Generation Sequencing and metagenomic Nanopore Sequencing for the diagnosis of tuberculosis in HIV-positive patients
Performance of metagenomic Next-Generation Sequencing and metagenomic Nanopore Sequencing for the diagnosis of tuberculosis in HIV-positive patients Open
Background Patients who were infected by the Human Immunodeficiency Virus ( HIV) could have weakened immunity that is complicated by opportunistic infections, especially for Mycobacterium tuberculosis (MTB). Notably, the HIV-MTB co-infecti…
View article: Interactions between HIV proteins and host restriction factors: implications for potential therapeutic intervention in HIV infection
Interactions between HIV proteins and host restriction factors: implications for potential therapeutic intervention in HIV infection Open
Different host proteins target different HIV proteins and antagonize their functions, depending on the stage of the HIV life cycle and the stage of infection. Concurrently, HIV proteins also target and antagonize various different host pro…
View article: HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis
HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis Open
HIV-associated neurocognitive disorder (HAND) is now recognized to be relatively common in people living with HIV (PLWH), and remains a common cause of cognitive impairment. Unfortunately, the fundamental pathogenic processes underlying th…
View article: Delving deeper into the mechanisms fundamental to HIV-associated immunopathology using single-cell sequencing techniques: A scoping review of current literature
Delving deeper into the mechanisms fundamental to HIV-associated immunopathology using single-cell sequencing techniques: A scoping review of current literature Open
View article: Switch to fixed-dose ainuovirine, lamivudine, and tenofovir DF versus elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed people living with HIV-1: the 48-week results of the SPRINT trial, a multi-centre, randomised, double-blind, active-controlled, phase 3, non-inferiority trial
Switch to fixed-dose ainuovirine, lamivudine, and tenofovir DF versus elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed people living with HIV-1: the 48-week results of the SPRINT trial, a multi-centre, randomised, double-blind, active-controlled, phase 3, non-inferiority trial Open
BACKGROUND: We compared the efficacy and safety profiles of ainuovirine (ANV), a new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), with boosted elvitegravir (EVG), both coformulated with two nucleoside reverse transcri…
View article: Prevalence and antimicrobial susceptibility pattern of Mycobacterium abscessus complex isolates in Chongqing, Southwest China
Prevalence and antimicrobial susceptibility pattern of Mycobacterium abscessus complex isolates in Chongqing, Southwest China Open
View article: Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma
Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma Open
In this research, we investigated the role of PIK3R6, a regulatory subunit of PI3Kγ, known for its tumor-promoting properties, in clear cell renal cell carcinoma (CCRCC). Utilizing the UALCAN website, we found PIK3R6 upregulated in CCRCC, …