Explanipedia

Fibroblast-derived NEU1 as a therapeutic target for improving cortical bone integrity and fracture healing Open

Yutong Wu, Ying Qu, Jiulin Tan, Nathachit Limjunyawong, Fei Luo , et al. · 2025

Long-Term Organic Fertilization and Straw Return Affect Shajiang Black Soil (Vertisol) Nutrient Availability, Aggregate Stability, and Crop Yield with the Winter Wheat–Summer Maize Double-Cropping System in Northern China Open

Jianrong Zhao, Yingying Tang, Ying Qu, Songling Chen, Fuwei Wang , et al. · 2025

Long-term fertilization affects soil nutrient levels and aggregate stability, eventually altering crop yield. However, their responses to organic fertilizer application and straw returning are still unclear, particularly as the contributio…

Salt stress enhances bioactive compound accumulation in Glycyrrhiza inflata: integrated transcriptomics and physiological analysis reveals germplasm-specific adaptation mechanisms Open

Bo Zhu, Linping Cheng, Nana Shi, Peirou Chen, Guo Fei , et al. · 2025

Introduction Glycyrrhiza inflata Batal., a halophytic plant predominantly found in the saline-alkali deserts of southern Xinjiang, China, is renowned for its abundance of bioactive compounds like flavonoids and triterpenoids. It demonstrat…

MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response Open

Elisabetta Cozzi, Anne Neddermeyer, Xiangfu Zhong, Angélica María Gamboa-Cedeño, Dimitris C. Kanellis , et al. · 2025

Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway Open

Qing Li, Fangfang Wang, Xinrong Xiang, Леи Жао, Xuefeng Li , et al. · 2025

Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Open

Ying Qu, Chen Chen, Feifei Sun, Shijia Liu, Guozhi Zhao , et al. · 2025

Early oxidative protein modifications and gut damage/leakiness contribute to drug-induced acute liver failure Open

Wiramon Rungratanawanich, Ying Qu, Andrew Holmes, Neil Kaplowitz, Byoung‐Joon Song · 2025

Innovative strategies for improving CAR-T cell therapy: A nanomedicine perspective Open

Mengyao Wang, Zhengyu Yu, Liping Yuan, Peipei Yang, Caixia Jing , et al. · 2025

Chimeric antigen receptor T (CAR-T) cells have reshaped the treatment landscape of hematological malignancies, offering a potentially curative option for patients. Despite these major milestones in the field of immuno-oncology, growing exp…

Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy Open

Zhichao Wang, Ying Qu, Xiangmei Liu, Jin Huang, Congyang Mao , et al. · 2025

Interplay of disulfidptosis and the tumor microenvironment across cancers: implications for prognosis and therapeutic responses Open

Shengshan Xu, Zizhou Chen, Xiguang Chen, Hongyu Chu, Xufeng Huang , et al. · 2025

The recent elucidation of disulfidptosis, a unique form of cell death, has opened new paths for the development of targeted cancer therapies. However, a thorough examination of disulfidptosis-related genes (DRGs) across various cancer type…

Multi-level correlation analysis of flower color and fragrance in wild tree peony (Paeonia suffruticosa) Open

Ying Qu, Chen Cheng, Yingying Zhang, Liyuan Zhao, Tianqi Tang , et al. · 2025

Pollen‐Inspired Aptamer Delivery System for Multi‐Target Therapy in Rheumatoid Arthritis Open

Wenxin Yang, Zhengrong Chen, Ying Qu, Peng Ye, Yong Tang , et al. · 2025

In rheumatoid arthritis (RA), the complex interplay of inflammatory mediators and cellular mechanisms presents challenges for effective treatment. Current therapies, often targeting singular pathways, achieve limited clinical remission. Th…

CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A Open

Haiyan Gu, Bo Han, Jing Hu, Ping Liu, Wenyao Liu , et al. · 2025

Advances in WRKY transcription factors' regulation of pigment and fragrance traits in plants: A review Open

Nuoxuan Liu, Huale Chen, Tianqi Tang, Yingying Zhang, Liyuan Zhao , et al. · 2025

Osteoclast-derived apoptotic bodies accelerate the pathological progression of osteoarthritis via disturbing subchondral bone remodeling Open

Hongbo Ai, Ce Dou, Yutong Wu, Dongyang Zhang, Ziyang Zhang , et al. · 2025

OC-ABs play a critical role in exacerbating OA by promoting subchondral bone remodeling via the RANKL reverse signaling pathway. Rapamycin presents as a promising therapeutic agent capable of mitigating OC-AB-driven pathology, highlighting…

Investigation of the impact of ultraviolet B irradiation on apoptosis and proliferation in A375 melanoma cells Open

Jingyang Wang, Zhixiang Yuan, Taoyu Chen, Jiaqi Guo, Ying Qu , et al. · 2025

The increasing environmental impact of ultraviolet B (UVB) radiation, exacerbated by ozone layer depletion and anthropogenic influences, highlights its dual threat to ecological balance and human health. This study examines the cytotoxic m…

Optimal techniques for obtaining superior liver specimens at endoscopic ultrasound-guided biopsy: a pilot study on pigs Open

Ying Wu, Ni Xie, Guiyang Su, Ying Qu, Jianbo Ni , et al. · 2025

Background Endoscopic ultrasound (EUS)-guided liver biopsy has been an effective method for acquiring liver tissue. However, currently, there is no consensus on the technical details of biopsy sampling. This study aimed to optimize the EUS…

Dual-Functional Probiotic Hydrogel with Puerarin Integration for Microbiota-Neuroimmune Regulation in Antibiotic-Free Periodontitis Therapy Open

Zhichao Wang, Ying Qu, Xiangmei Liu, Jin Huang, Congyang Mao , et al. · 2025

The Impact of Bundled Nursing Interventions Based on Empowerment Theory on Patients with Indwelling Urinary Catheters Open

Ying Qu · 2024

Objective: To explore the value of bundled nursing interventions based on empowerment theory in the care of patients with indwelling urinary catheters. Methods: Forty-two patients with indwelling urinary catheters, admitted from June 2022 …

Study on Healing Treatment of Chronic Wound Open

Chengyi Qin, Ying Qu, Zhengqing Qiu, Changshuai Qin, Changgong Lan · 2024

Chronic wound is one of the difficulties in clinical treatment. The complex pathological mechanism of chronic wound involves many links, such as inflammation disorder, cell proliferation obstruction, insufficient angiogenesis and abnormal …

Research and practice on ideological and political construction of mobile communication professional courses guided by moral cultivation and talent cultivation Open

Jifu Wang, Ying Qu, Li Bing, Liu Zhong-wei, Haitao Xiang · 2024

Focusing on the ideological and political construction of mobile communication professional courses guided by moral cultivation and talent cultivation, by analyzing its development status and existing problems, corresponding research strat…

The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia Open

Daniel Hägerstrand, Blaž Oder, Diego Cortese, Ying Qu, Amrei Binzer-Panchal , et al. · 2024

Analysis and study on biomarkers of local muscle fatigue caused by repetitive lifting task Open

Siwu Zhong, Ning Jia, Ying Qu, Xueyan Zhang, Qing Xu , et al. · 2024

Comparison of allo-SCT, auto-SCT and chemotherapy for the treatment of patients with low- or intermediate-risk acute myeloid leukemia: a network meta-analysis Open

Ye Wu, Xia Wu, Ruying Zhao, Xuelian Jin, Hui Li , et al. · 2024

Background The therapeutic status of allogeneic stem cell transplantation (allo-SCT) as a post-remission treatment for patients with high-risk acute myeloid leukemia (AML) was well-accepted. However, the optimal treatment for patients with…

Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress‐associated mitochondrial apoptotic pathway Open

Zhongshang Sun, Yuecheng Guo, Xianjun Xu, Cui Zhou, Xin Luo , et al. · 2024

Background and Aim Hydronidone (HDD) is a novel pirfenidone derivative developed initially to reduce hepatotoxicity. Our previous studies in animals and humans have demonstrated that HDD treatment effectively attenuates liver fibrosis, yet…

Transcriptomics Reveal an Integrated Gene Regulation Network of Early Flowering Development in an Oil Sunflower Mutant Induced by Heavy Ion Beam Open

Xiao Liu, Xuhui Mao, Jihong Chen, Yan Du, Wenjie Jin , et al. · 2024

The oil sunflower is an important oil crop and ornamental plant. Flowering time affects the environmental adaptability and final yield of oil sunflowers. Floral induction is one of the important events that determines subsequent reproducti…

Assessment of Different Strategies for ROI-Based Measurements of Proton Density Fat Fraction in NAFLD Open

Jingyi Lu, Youchen Xia, Rong Mu, Qian Luo, Lei Zhang , et al. · 2024

Aims: MRI-PDFF is a promising non-invasive method of quantifying liver fat. This study assessed the reproducibility and repeatability of MRI-based PDFF in NAFLD patients, the consistency between different ROI sampling strategies, as well a…

Post-translational modifications of Keap1: the state of the art Open

Yunjia Song, Ying Qu, Caiyun Mao, Rong Zhang, Deyou Jiang , et al. · 2024

The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative stress-induced damage. Its activation entails the expression and transcriptional regulation of several proteins involved in detoxification and anti…

A Robust and Efficient Deep Optimization Network for Spatiotemporal Data Fusion Open

Decai Jin, Xiufang Zhu, Ying Qu, Jianbo Qi, Hanyi Wu , et al. · 2024

Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction Open

Man Wang, Ying Qu, Shujin Wang, Zhongsen Qu · 2024

Objective To explore the role of oxidative stress on glycogen synthase kinase-3 in lymphocytes of diabetes mellitus (DM) patients complicated with cerebral infarction (CI). Materials and methods A total of 186 DM patients were enrolled acc…

Ying Qu YOU? Author Swipe