Yaoqiang Zheng
YOU?
Author Swipe
View article: Systematic decoding of functional enhancer connectomes and risk variants in human glioma
Systematic decoding of functional enhancer connectomes and risk variants in human glioma Open
Genetic and epigenetic variations contribute to the progression of glioma, but the mechanisms underlying these effects, particularly for enhancer-associated genetic variations in non-coding regions, still remain unclear. Here we performed …
View article: Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide Open
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modul…
View article: Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis
Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis Open
Ferroptosis is an iron-dependent form of cell death, which is reported to be associated with glioma progression and drug sensitivity. Targeting ferroptosis is a potential therapeutic approach for glioma. However, the molecular mechanism of…
View article: KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure
KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure Open
Neural differentiation of embryonic stem cells (ESCs) requires precisely orchestrated gene regulation, a process governed in part by changes in 3D chromatin structure. How these changes regulate gene expression in this context remains uncl…