Yu Lan
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View article: Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy Open
Acute lung injury (ALI) has been a kind of acute and severe disease that is mainly characterized by systemic uncontrolled inflammatory response to the production of huge amounts of reactive oxygen species (ROS) in the lung tissue. Given th…
View article: NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy
NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy Open
Sepsis induced acute liver injury (SALI), is a type of acute and severe disease that is generally characterized by producing significant amounts of reactive oxygen species (ROS) in liver tissue, and in response to excessive ROS, producing …
View article: Comparative and phylogenetic analysis of complete chloroplast genomes of Phrynium s. s. and Stachyphrynium (Marantaceae) in China, including a new species
Comparative and phylogenetic analysis of complete chloroplast genomes of Phrynium s. s. and Stachyphrynium (Marantaceae) in China, including a new species Open
Plants of the genera Phrynium and Stachyphrynium traditionally used as ethnomedicine or for wrapping sticky rice dumpling in the tropical and south subtropical Asia, have a long history of ethnobotanical use. China represents the northernm…
View article: Hydrogen-bond mediated electrocatalytic nitrate reduction to ammonia over metal–organic frameworks with industrial current density
Hydrogen-bond mediated electrocatalytic nitrate reduction to ammonia over metal–organic frameworks with industrial current density Open
A hydrogen bonding strategy is proposed to stabilize *NO 2 intermediates to improve the activity of the NO 3 − reduction reaction. The optimal DiMe-Cu 3 -MOF shows high NH 3 faradaic efficiency (95%) and large partial current density of −9…
View article: The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis
The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis Open
The tongue is a highly specialized muscular organ with diverse cellular origins, which provides an excellent model for understanding mechanisms controlling tissue-tissue interactions during organogenesis. Previous studies showed that SHH s…
View article: MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity
MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity Open
Tooth agenesis is a common structural birth defect in humans that results from failure of morphogenesis during early tooth development. The homeobox transcription factor Msx1 and the canonical Wnt signaling pathway are essential for “bud t…
View article: Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia
Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia Open
Loss of ALX1 function causes the frontonasal dysplasia syndrome FND3, characterized by severe facial clefting and microphthalmia. Whereas the laboratory mouse has been the preeminent animal model for studying developmental mechanisms of hu…
View article: The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation
The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation Open
Proper development of tendons is crucial for the integration and function of the musculoskeletal system. Currently little is known about the molecular mechanisms controlling tendon development and tendon cell differentiation. The transcrip…
View article: Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development
Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development Open
Disruption of FOXF2 , encoding a member of the Forkhead family transcription factors, has been associated with cleft palate in humans and mice. FOXF2 is located in a conserved gene cluster containing FOXQ1 , FOXF2 , and FOXC1 . We found th…
View article: Tissue‐specific analysis of <i>Fgf18</i> gene function in palate development
Tissue‐specific analysis of <i>Fgf18</i> gene function in palate development Open
Background Previous studies showed that mice lacking Fgf18 function had cleft palate defects and that the FGF18 locus was associated with cleft lip and palate in humans, but what specific roles Fgf18 plays during palatogenesis are unclear.…
View article: Generation and characterization of <i>Six2</i> conditional mice
Generation and characterization of <i>Six2</i> conditional mice Open
Summary Heterozygous deletion of Six2 , which encodes a member of sine oculis homeobox family transcription factors, has recently been associated with the frontonasal dysplasia syndrome FND4. Previous studies showed that Six2 is expressed …
View article: Genome-wide Identification of Foxf2 Target Genes in Palate Development
Genome-wide Identification of Foxf2 Target Genes in Palate Development Open
Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network…
View article: Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development
Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development Open
Cleft palate is a common major birth defect resulting from disruption of palatal shelf growth, elevation, or fusion during fetal palatogenesis. Whereas the molecular mechanism controlling palatal shelf elevation is not well understood, a p…
View article: Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development
Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development Open
SIX1 and SIX2 encode closely related transcription factors of which disruptions have been associated with distinct craniofacial syndromes, with mutations in SIX1 associated with branchiootic syndrome 3 (BOS3) and heterozygous deletions of …
View article: Hedgehog signaling patterns the oral-aboral axis of the mandibular arch
Hedgehog signaling patterns the oral-aboral axis of the mandibular arch Open
Development of vertebrate jaws involves patterning neural crest-derived mesenchyme cells into distinct subpopulations along the proximal-distal and oral-aboral axes. Although the molecular mechanisms patterning the proximal-distal axis hav…
View article: Molecular and Cellular Mechanisms of Palate Development
Molecular and Cellular Mechanisms of Palate Development Open
Development of the mammalian secondary palate involves highly dynamic morphogenetic processes, including outgrowth of palatal shelves from the oral side of the embryonic maxillary prominences, elevation of the initially vertically oriented…
View article: Identification of Osr2 Transcriptional Target Genes in Palate Development
Identification of Osr2 Transcriptional Target Genes in Palate Development Open
Previous studies have identified the odd-skipped related 2 (Osr2) transcription factor as a key intrinsic regulator of palatal shelf growth and morphogenesis. However, little is known about the molecular program acting downstream of Osr2 i…
View article: Modulating Wnt Signaling Rescues Palate Morphogenesis in <i>Pax9</i> Mutant Mice
Modulating Wnt Signaling Rescues Palate Morphogenesis in <i>Pax9</i> Mutant Mice Open
Cleft palate is a common birth defect caused by disruption of palatogenesis during embryonic development. Although mutations disrupting components of the Wnt signaling pathway have been associated with cleft lip and palate in humans and mi…
View article: Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis
Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis Open
Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba −/− ) and mice with neural crest–specific inactivation of Bmp4 ( Bm…
View article: Golga5 is dispensable for mouse embryonic development and postnatal survival
Golga5 is dispensable for mouse embryonic development and postnatal survival Open
Summary Golgins are a family of coiled‐coil proteins located at the cytoplasmic surface of the Golgi apparatus and have been implicated in maintaining Golgi structural integrity through acting as tethering factors for retrograde vesicle tr…
View article: Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis Open
Renal hypoplasia is a common cause of pediatric renal failure and several adult-onset diseases. Recent studies have associated a variant of the OSR1 gene with reduction of newborn kidney size and function in heterozygotes and neonatal leth…
View article: A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development Open
Cleft palate is among the most common birth defects in humans. Previous studies have shown that Shh signaling plays critical roles in palate development and regulates expression of several members of the forkhead-box (Fox) family transcrip…
View article: Golgb1 regulates protein glycosylation and is crucial for mammalian palate development
Golgb1 regulates protein glycosylation and is crucial for mammalian palate development Open
Cleft palate is a common major birth defect for which currently known causes account for less than 30% of pathology in humans. In this study, we carried out mutagenesis screening in mice to identify new regulators of palatogenesis. Through…
View article: Deletion of <i>Osr2</i> Partially Rescues Tooth Development in <i>Runx2</i> Mutant Mice
Deletion of <i>Osr2</i> Partially Rescues Tooth Development in <i>Runx2</i> Mutant Mice Open
Tooth organogenesis depends on genetically programmed sequential and reciprocal inductive interactions between the dental epithelium and neural crest–derived mesenchyme. Previous studies showed that the Msx1 and Runx2 transcription factors…
View article: Whole transcriptome expression profiling of mouse limb tendon development by using RNA‐seq
Whole transcriptome expression profiling of mouse limb tendon development by using RNA‐seq Open
Tendons are fibrous connective tissues that transmit force between muscle and bone. Whereas the molecular and cellular mechanisms of bone and muscle development have been well studied, that of tendon development is poorly understood. Using…