Yaoska Reyes
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Author Swipe
View article: Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human Norovirus
Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Serum Dimeric and Monomeric IgA to Human Norovirus Open
Protection against human norovirus infection, which is the major cause of acute gastroenteritis, is strongly correlated with humoral immunity, particularly with IgA binding titers in serum and mucosal surfaces. Serum IgA is mostly monomeri…
View article: Natural history and impact of <i>Giardia lamblia</i> on child growth attainment and associated pathway-specific biomarkers in a Nicaraguan birth cohort
Natural history and impact of <i>Giardia lamblia</i> on child growth attainment and associated pathway-specific biomarkers in a Nicaraguan birth cohort Open
Background Giardia lamblia ( Giardia ) is one of the most common intestinal parasitic infections globally, with an estimated 280 million symptomatic infections annually. In children from low-and middle-income countries (LMICs), Giardia is …
View article: Proteomic deconvolution of the antigen-specific serum IgA repertoire reveals clonal overlap with IgG and between monomeric and dimeric IgA following mucosal norovirus vaccination 2438
Proteomic deconvolution of the antigen-specific serum IgA repertoire reveals clonal overlap with IgG and between monomeric and dimeric IgA following mucosal norovirus vaccination 2438 Open
Description IgA antibodies are key to mucosal immunity; however, the identity, abundance, and oligomeric states of individual IgA clonotypes comprising the polyclonal repertoire remain poorly understood. To determine the molecular nature a…
View article: Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort.
Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort. Open
BACKGROUND: Giardia lamblia is an intestinal protozoan estimated to cause ~200 million symptomatic infections annually, mainly in children in low- and middle-income countries associated with intestinal damage, increased permeability, and m…
View article: Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort
Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort Open
Background Giardia lamblia is an intestinal protozoan estimated to cause ~200 million symptomatic infections annually, mainly in children in low- and middle-income countries associated with intestinal damage, increased permeability, and ma…
View article: Epidemiology of Pediatric Astrovirus Gastroenteritis in a Nicaraguan Birth Cohort
Epidemiology of Pediatric Astrovirus Gastroenteritis in a Nicaraguan Birth Cohort Open
Background Astrovirus is a leading cause of acute gastroenteritis in children worldwide. However, few prospective studies have analyzed astrovirus in community-dwelling pediatric populations in low- and middle-income countries. Methods We …
View article: Charting the Impact of Maternal Antibodies and Repeat Exposures on Sapovirus Immunity in Early Childhood From a Nicaraguan Birth Cohort
Charting the Impact of Maternal Antibodies and Repeat Exposures on Sapovirus Immunity in Early Childhood From a Nicaraguan Birth Cohort Open
Background Sapovirus is an important cause of acute gastroenteritis in childhood. While vaccines against sapovirus may reduce gastroenteritis burden, a major challenge to their development is a lack of information about natural immunity. M…
View article: Correction: Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort
Correction: Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort Open
[This corrects the article DOI: 10.1371/journal.pone.0267689.].
View article: Transmission Patterns of Norovirus From Infected Children to Household Members in León, Nicaragua
Transmission Patterns of Norovirus From Infected Children to Household Members in León, Nicaragua Open
Norovirus is a common and highly transmissible gastrointestinal pathogen. Among 34 Nicaraguan households with a norovirus-infected child, 48% experienced norovirus transmission within 1 week, infecting 18% of household members; GII norovir…
View article: Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters
Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters Open
Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in both high- and low-income countries. GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential …
View article: First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort
First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort Open
Background: Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes. Methods: Between June 2017 and Jul…
View article: Epidemiology of pediatric astrovirus gastroenteritis in a Nicaraguan birth cohort
Epidemiology of pediatric astrovirus gastroenteritis in a Nicaraguan birth cohort Open
Background Astrovirus is a leading cause of acute gastroenteritis in children worldwide. However, few prospective studies have analyzed astrovirus in community-dwelling pediatric populations in low-and-middle-income countries. Methods We a…
View article: Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters
Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters Open
Genogroup II (GII) noroviruses are a major cause of diarrheal disease burden in children in both high- and low-income countries. GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential …
View article: Zika rna and flavivirus-like antigens in the sperm cells of symptomatic and asymptomatic subjects
Zika rna and flavivirus-like antigens in the sperm cells of symptomatic and asymptomatic subjects Open
Zika virus (ZIKV) RNA has been found to remain in human semen for up to one year after infection, but the presence of Flavivirus antigens in the different compartments of semen has been largely unexplored. Following the introduction of ZIK…
View article: Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort
Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort Open
BACKGROUND: The role of histo-blood group on the burden and severity of norovirus gastroenteritis in young infants has not been well documented. METHODS: Norovirus gastroenteritis was assessed in 443 Nicaraguan children followed from birth…
View article: Clinical and epidemiological features of acute zika virus infections in León, Nicaragua
Clinical and epidemiological features of acute zika virus infections in León, Nicaragua Open
The American Zika virus (ZIKV) epidemic has highlighted the need to gain a better understanding of this emerging virus. The goal of this study was to describe the clinical symptoms, laboratory findings, and risk factors for symptomatic ZIK…
View article: Risk Factors and Clinical Profile of Sapovirus-associated Acute Gastroenteritis in Early Childhood: A Nicaraguan Birth Cohort Study
Risk Factors and Clinical Profile of Sapovirus-associated Acute Gastroenteritis in Early Childhood: A Nicaraguan Birth Cohort Study Open
Background: Sapovirus is increasingly recognized as an important cause of acute gastroenteritis (AGE) in children. We identified risk factors and characterized the clinical profile of sapovirus AGE in a birth cohort in León, Nicaragua. Met…
View article: Clinical characteristics, risk factors, and population attributable fraction for campylobacteriosis in a nicaraguan birth cohort
Clinical characteristics, risk factors, and population attributable fraction for campylobacteriosis in a nicaraguan birth cohort Open
Campylobacteriosis is an important contributor to the global burden of acute gastroenteritis (AGE). In Nicaragua, the burden, risk factors, and species diversity for infant campylobacteriosis are unknown. Between June 2017 and December 201…
View article: Nonsecretor Phenotype Is Associated With Less Risk of Rotavirus-Associated Acute Gastroenteritis in a Vaccinated Nicaraguan Birth Cohort
Nonsecretor Phenotype Is Associated With Less Risk of Rotavirus-Associated Acute Gastroenteritis in a Vaccinated Nicaraguan Birth Cohort Open
Background Histo-blood group antigens (HBGAs) have been associated with rotavirus vaccine take; but the effect of these HBGAs on rotavirus incidence and risk remains poorly explored in vaccinated populations. Methods Rotavirus-associated a…
View article: Household Surveillance for Norovirus Gastroenteritis in a Nicaraguan Birth Cohort: A Nested Case—Control Analysis of Norovirus Risk Factors
Household Surveillance for Norovirus Gastroenteritis in a Nicaraguan Birth Cohort: A Nested Case—Control Analysis of Norovirus Risk Factors Open
Norovirus causes a large proportion of pediatric acute gastroenteritis (AGE) worldwide, and no vaccines are currently available. To inform public health measures against norovirus gastroenteritis, we assessed risk factors in a case–control…
View article: Household Surveillance for Norovirus Gastroenteritis in a Nicaraguan Birth Cohort: A Nested Case—Control Analysis of Norovirus Risk Factors
Household Surveillance for Norovirus Gastroenteritis in a Nicaraguan Birth Cohort: A Nested Case—Control Analysis of Norovirus Risk Factors Open
Norovirus causes a large proportion of pediatric acute gastroenteritis (AGE) worldwide, and no vaccines are currently available. To inform public health measures against norovirus gastroenteritis, we assessed risk factors in a case–control…
View article: Nonsecretor Phenotype Is Associated With Less Risk of Rotavirus-Associated Acute Gastroenteritis in a Vaccinated Nicaraguan Birth Cohort
Nonsecretor Phenotype Is Associated With Less Risk of Rotavirus-Associated Acute Gastroenteritis in a Vaccinated Nicaraguan Birth Cohort Open
BACKGROUND: Histo-blood group antigens (HBGAs) have been associated with rotavirus vaccine take; but the effect of these HBGAs on rotavirus incidence and risk remains poorly explored in vaccinated populations. METHODS: Rotavirus-associated…
View article: Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort
Timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort Open
View article: Norovirus and rotavirus susceptibility : studies from a Nicaraguan birth cohort
Norovirus and rotavirus susceptibility : studies from a Nicaraguan birth cohort Open
Norovirus and rotavirus are major causes of pediatric acute gastroenteritis (AGE). It is estimated that norovirus is responsible for ~20% of all diarrheal diseases in children worldwide and causes approximately 200,000 deaths each year, mo…
View article: Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort
Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort Open
Background Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. Me…
View article: Norovirus Infection in Young Nicaraguan Children Induces Durable and Genotype-Specific Antibody Immunity
Norovirus Infection in Young Nicaraguan Children Induces Durable and Genotype-Specific Antibody Immunity Open
There are significant challenges to the development of a pediatric norovirus vaccine, mainly due to the antigenic diversity among strains infecting young children. Characterizing human norovirus serotypes and understanding norovirus immuni…
View article: Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children
Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children Open
A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had …
View article: First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort
First Episodes of Norovirus and Sapovirus Gastroenteritis Protect Against Subsequent Episodes in a Nicaraguan Birth Cohort Open
Background: Norovirus and sapovirus cause a large burden of acute gastroenteritis (AGE) in young children. We assessed protection conferred by norovirus and sapovirus AGE episodes against future episodes. Methods: Between June 2017 and Jul…
View article: Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort
Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort Open
Background Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. Me…
View article: Clinical and Epidemiological Features of Acute Zika Virus Infections in León, Nicaragua
Clinical and Epidemiological Features of Acute Zika Virus Infections in León, Nicaragua Open
The American Zika virus (ZIKV) epidemic has highlighted the need to gain a better understanding of this emerging virus. The goal of this study was to describe the clinical symptoms, laboratory findings, and risk factors for symptomatic ZIK…