Yunpeng Guan
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View article: Integrated bulk sequencing and single-cell transcriptomic profiling implicates neutrophil-driven hypoxia in atrial fibrillation development
Integrated bulk sequencing and single-cell transcriptomic profiling implicates neutrophil-driven hypoxia in atrial fibrillation development Open
Our integrative analysis implicates neutrophil-driven hypoxia in AF pathogenesis, while the neutrophil-based diagnostic model demonstrates robust AF and SR discrimination. However, the validity of our findings awaits confirmation through <…
View article: Analysis of factors influencing changes in medical behavior under the context of DRG payment method reform: a structural equation modeling approach
Analysis of factors influencing changes in medical behavior under the context of DRG payment method reform: a structural equation modeling approach Open
Objectives This study aims to assess the understanding of policies, cognitive awareness, and medical behavior patterns among healthcare workers about the reform of the diagnosis-related group (DRG) payment method. A questionnaire survey wa…
View article: Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study
Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study Open
View article: Serum Gamma Glutamyltransferase: A Biomarker for Identifying Postprandial Hypertriglyceridemia
Serum Gamma Glutamyltransferase: A Biomarker for Identifying Postprandial Hypertriglyceridemia Open
Serum GGT levels are significantly associated with PHTG risk and serve as an effective biomarker for early identification.
View article: Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level
Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level Open
Fasting FGF21 levels showed a strong positive correlation with FFA. During OFTT, changes in FGF21 levels were closely associated with alterations in FFA exogenously changed by OFTT. Moreover, they were linearly related to each other. There…
View article: A bibliometric analysis and visualization of literature on non-fasting lipid research from 2012 to 2022
A bibliometric analysis and visualization of literature on non-fasting lipid research from 2012 to 2022 Open
Background Non-fasting lipid assessment can help predict cardiovascular disease risks and is linked to multiple diseases, particularly diabetes. The significance of non-fasting lipid levels in routine screening and postprandial lipid tests…
View article: Oral fat tolerance testing identifies abnormal pancreatic <scp>β‐cell</scp> function and insulin resistance in individuals with normal glucose tolerance
Oral fat tolerance testing identifies abnormal pancreatic <span>β‐cell</span> function and insulin resistance in individuals with normal glucose tolerance Open
Aims/Introduction Insulin sensitivity and β‐cell function are affected by lipid metabolism disorders, even before the onset of type 2 diabetes. People are in the postprandial state most of the time. Therefore, identifying postprandial hype…
View article: Identification of the Chinese Population That Can Benefit Most From Postprandial Lipid Testing: Validation of the Use of Oral Fat Tolerance Testing in Clinical Practice
Identification of the Chinese Population That Can Benefit Most From Postprandial Lipid Testing: Validation of the Use of Oral Fat Tolerance Testing in Clinical Practice Open
Background Dyslipidemia has become increasingly prevalent in recent decades. Blood lipid concentrations are significantly influenced by diet; however, postprandial triglyceride concentration (PTG) is not often measured. PTG can reflect the…
View article: Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet Open
Background: Diabetic kidney disease is a major cause of global end-stage renal diseases. Ectopic lipid deposition in the renal tissues of diabetic kidney disease is one major factor leading to renal fibrosis and chronic kidne…
View article: A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test
A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test Open
View article: Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia Open
Background To investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal. Methods The study has been registered w…
View article: A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test
A Correlation Study Between Non-alcoholic Fatty Liver Disease and Serum Triglyceride Level After an Oral Fat Tolerance Test Open
Background : Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide. High postprandial serum lipid concentrations have been reported in patients with metabolic syndrome. Meanwhile, post…
View article: The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province Open
Background. Our aim was to investigate the association between the genetics of the angiopoietin protein-like 8 (ANGPTL8) rs2278426 (C/T) polymorphism with prediabetes (pre-DM) and type 2 diabetes (T2DM) in a Han Chinese population in Hebei…