Yaping Li
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View article: Effect of pressure-controlled ventilation-volume guaranteed mode on intraoperative respiratory mechanics, oxygenation and postoperative pulmonary complications: a systematic review and network meta-analysis
Effect of pressure-controlled ventilation-volume guaranteed mode on intraoperative respiratory mechanics, oxygenation and postoperative pulmonary complications: a systematic review and network meta-analysis Open
PCV-VG was superior to VCV in Cdyn and Ppeak, PCV only achieved higher Cdyn than VCV for prone position. The three modes did not differ in Vt, Pmean, PetCO2, pH, PaCO2, PaO2, OI, and PPCs for patients under…
View article: Regulatory role of gut microbiota in chronic hepatitis B: A perspective from the gut-liver axis
Regulatory role of gut microbiota in chronic hepatitis B: A perspective from the gut-liver axis Open
View article: Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages
Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages Open
NLRP3 (NLR family pyrin domain-containing 3) inflammasome is a first line of defense of innate immunity, mediating caspase-1-dependent pyroptosis and cytokine release upon danger signaling. Intervention of NLRP3 innate surveillance may cau…
View article: <i>APOE</i> ε4 disrupts neuronal and network‐level function in the anterior olfactory nucleus: Influence of age and sex
<i>APOE</i> ε4 disrupts neuronal and network‐level function in the anterior olfactory nucleus: Influence of age and sex Open
INTRODUCTION Apolipoprotein E ( APOE ) ε4 is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), which features early olfactory dysfunction and pathology. However, how APOE ε4 interacts with age and sex to affect cellu…
View article: Author Correction: Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway
Author Correction: Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway Open
View article: The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice
The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice Open
Modern life’s fast-paced and the unexpected conditions contribute to escalating stress levels, often leading to anxiety disorders and posing significant challenges to physical and mental health. In judicial practice, the parties often suff…
View article: Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress
Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress Open
View article: Landscape and m6A post-transcriptional regulation of soybean proteome
Landscape and m6A post-transcriptional regulation of soybean proteome Open
The soybean is a critical source of vegetable protein, but its proteome remains undercharacterized. Here, we quantify 12,855 proteins across 14 soybean organs using 4D data-independent acquisition mass spectrometry (4D-DIA-MS), creating th…
View article: Seawater temperature recorded in the last phase of Late Cretaceous in the Yarkand Basin
Seawater temperature recorded in the last phase of Late Cretaceous in the Yarkand Basin Open
View article: The clinical application of mitoxantrone hydrochloride tracing in endoscopic radical resection of thyroid carcinoma
The clinical application of mitoxantrone hydrochloride tracing in endoscopic radical resection of thyroid carcinoma Open
View article: Dynamics of Aromia bungii (Faldermann, 1835) (Coleoptera, Cerambycidae) Distribution in China Amidst Climate Change: Dual Insights from MaxEnt and Meta-Analysis
Dynamics of Aromia bungii (Faldermann, 1835) (Coleoptera, Cerambycidae) Distribution in China Amidst Climate Change: Dual Insights from MaxEnt and Meta-Analysis Open
Aromia bungii Faldermann (Coleoptera, Cerambycidae) is one of the most serious stem-boring pests that infests Rosaceae fruit trees and ornamental trees. This study, based on occurrence data for this species, employed the MaxEnt model and m…
View article: Correction: MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
Correction: MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer Open
View article: Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating Nrf2 signaling
Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating Nrf2 signaling Open
Ferroptosis is a lytic form of regulated cell death that is driven by iron-dependent lipid peroxidation and has been implicated in various diseases, including acute kidney injury (AKI). Scutellarin is a flavonoid isolated from Erigeron …
View article: Enhanced antibody-mediated cellular cytotoxicity of germline-like anti-HER2 antibodies through a point mutation in complementarity-determining regions
Enhanced antibody-mediated cellular cytotoxicity of germline-like anti-HER2 antibodies through a point mutation in complementarity-determining regions Open
Human epidermal growth factor receptor 2 (HER2) is highly overexpressed on the surface of breast cancer cells, presenting an attractive target for therapeutic antibodies. Antibody-dependent cellular cytotoxicity (ADCC) is a central mechani…
View article: Plasma nontargeted metabolomics study of H1N1 and H3N2 influenza in children
Plasma nontargeted metabolomics study of H1N1 and H3N2 influenza in children Open
Background This study used a nontargeted metabolomic approach to investigate small molecular metabolites in the peripheral blood of pediatric patients with influenza. By comparing these metabolites with those in healthy children, potential…
View article: Harnessing lysosomal genetics: development of a risk stratification panel and unveiling of DPP7 as a biomarker for colon adenocarcinoma
Harnessing lysosomal genetics: development of a risk stratification panel and unveiling of DPP7 as a biomarker for colon adenocarcinoma Open
Lysosomal dysfunction has been implicated in the progression of colon adenocarcinoma (COAD), yet the prognostic significance and therapeutic potential of lysosome-related genes (LRGs) remain underexplored. In this study, we construct a 6-L…
View article: Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species Open
Ferroptosis, a form of iron‐dependent cell death, plays a pivotal role in age‐related diseases; yet, its impact on cellular senescence and healthspan in mammals remains largely unexplored. This study identifies ferroptosis as a key regulat…
View article: Timing of venoarterial extracorporeal membrane oxygenation in infant cardiac surgery: a single-centre retrospective study of clinical outcomes
Timing of venoarterial extracorporeal membrane oxygenation in infant cardiac surgery: a single-centre retrospective study of clinical outcomes Open
View article: Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration
Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration Open
The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable o…
View article: Retraction Note: Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma
Retraction Note: Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma Open
View article: CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway Open
CHMP4C promotes PC progression by inhibiting necroptosis, which has potential as a biomarker and therapeutic target in PC.
View article: Simulation of Binary-Single Interactions in AGN Disk I: Gas-Enhanced Binary Orbital Hardening
Simulation of Binary-Single Interactions in AGN Disk I: Gas-Enhanced Binary Orbital Hardening Open
Stellar-mass binary black hole\,(BBH) mergers within the accretion disks of active galactic nuclei may contribute to gravitational wave\,(GW) events detected by grounded-based GW detectors. In particular, the interaction between a BBH and …
View article: Synthetic Biology‐Based Engineering Cells for Drug Delivery
Synthetic Biology‐Based Engineering Cells for Drug Delivery Open
Although drug delivery technology has promoted the clinical translation of small molecule drugs, there is an urgent need for advanced delivery systems to overcome complex physiological barriers and the increasing development of biological …
View article: Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer
Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer Open
View article: An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus
An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. The inconsistent prevalence of SLE between monozygotic twins suggests that environmental factors affect the occurrence of this disease. Abnormal epigenetic regulation is s…
View article: Potential mechanisms and therapeutic prospects of the association between <i>Helicobacter pylori</i> infection and metabolic dysfunction-associated steatohepatitis
Potential mechanisms and therapeutic prospects of the association between <i>Helicobacter pylori</i> infection and metabolic dysfunction-associated steatohepatitis Open
Helicobacter pylori (H. pylori ) infection is a known inducer of various gastrointestinal diseases, including gastritis, gastric ulcers, and gastric cancer. However, in recent years, research on the potential association between H. pylori …
View article: AT2021aeuk: A Repeating Partial Tidal Disruption Event Candidate in a Narrow-line Seyfert 1 galaxy
AT2021aeuk: A Repeating Partial Tidal Disruption Event Candidate in a Narrow-line Seyfert 1 galaxy Open
A black hole (BH) can tear apart a star that ventures within its tidal radius, producing a luminous flare as the stellar debris falls back, known as a tidal disruption event (TDE). While TDEs in quiescent galaxies are relatively well under…
View article: Effectiveness and Safety of Tenofovir Amibufenamide in the Treatment of Chronic Hepatitis B: A Real-world, Multicenter Study
Effectiveness and Safety of Tenofovir Amibufenamide in the Treatment of Chronic Hepatitis B: A Real-world, Multicenter Study Open
TMF is comparable to TDF in terms of CHB treatment effectiveness, with better renal safety and no impact on lipid levels. In TE patients, transitioning to TMF therapy does not affect antiviral treatment outcomes.
View article: Development of Sci‐Tech Journals in China Stimulated by the China Sci‐Tech Journal Excellence Action Plan
Development of Sci‐Tech Journals in China Stimulated by the China Sci‐Tech Journal Excellence Action Plan Open
This study aims to evaluate the influence of the China Sci‐Tech Journal Excellence Action Plan (CJEAP) on the development of Chinese science and technology (sci‐tech) journals. The performance of bibliometric indicators of these journals b…
View article: Transcriptomic Analysis Reveals the Mechanism by Which Alanyl-Glutamine (Ala-Gln) Alleviates Aeromonas hydrophila-Induced Intestinal Damage in Loach (Paramisgurnus dabryanus)
Transcriptomic Analysis Reveals the Mechanism by Which Alanyl-Glutamine (Ala-Gln) Alleviates Aeromonas hydrophila-Induced Intestinal Damage in Loach (Paramisgurnus dabryanus) Open