Yaping Qin
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View article: Attenuation and altered replication of IBV strain tl/CH/LDT3/03 after serial passage in chicken embryo fibroblasts and Vero cells
Attenuation and altered replication of IBV strain tl/CH/LDT3/03 after serial passage in chicken embryo fibroblasts and Vero cells Open
To adapt the infectious bronchitis virus (IBV) for cell culture, the tl/CH/LDT3/03 strain was subjected to serial passaging in chicken embryo fibroblasts (CEFs) and Vero cells, respectively. Cytopathic effects (CPEs) first became apparent …
View article: UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein
UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein Open
Host factor-mediated post-translational modification of coronavirus proteins has been demonstrated as an important strategy for regulating viral proliferation. Identification of key host genes involved in this process may provide potential…
View article: Altered Characteristics of an Infectious Bronchitis Virus Strain Tl/Ch/Ldt3/03 Adapted in Chicken Embryo Fibroblasts and Vero Cells
Altered Characteristics of an Infectious Bronchitis Virus Strain Tl/Ch/Ldt3/03 Adapted in Chicken Embryo Fibroblasts and Vero Cells Open
View article: Map-based cloning and allelic analysis of gene controlling maize kernel mutant crk4
Map-based cloning and allelic analysis of gene controlling maize kernel mutant crk4 Open
View article: The evolution of SARS-CoV-2 and the COVID-19 pandemic
The evolution of SARS-CoV-2 and the COVID-19 pandemic Open
Scientists have made great efforts to understand the evolution of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) to provide crucial information to public health experts on strategies to control this viral pathogen. The pandem…
View article: P-705 Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency
P-705 Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency Open
Study question Are the gene variants involved in meiosis initiation responsible for premature ovarian insufficiency (POI)? Summary answer MEIOSIN variant participates in the pathogenesis of human POI by impairing meiosis due to insufficien…
View article: Novel CuMgAlTi-LDH Photocatalyst for Efficient Degradation of Microplastics under Visible Light Irradiation
Novel CuMgAlTi-LDH Photocatalyst for Efficient Degradation of Microplastics under Visible Light Irradiation Open
Microplastics (MPs) in the water system could easily enter the human body and pose a potential threat, so finding a green and effective solution remains a great challenge. At present, the advanced oxidation technology represented by photoc…
View article: Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report
Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report Open
The effectiveness of the tyrosine kinase inhibitor ALK (TKI) for non-small cell lung cancer has been confirmed. However, resistance to ALK-TKIs seems inevitable. Mutations in the ALK kinase domain have been reported as an important mechani…
View article: Case Report: A Case Report of a Histological Transformation of ALK-Rearranged Adenocarcinoma With High Expression of PD-L1 to Squamous Cell Carcinoma After Treatment With Alectinib
Case Report: A Case Report of a Histological Transformation of ALK-Rearranged Adenocarcinoma With High Expression of PD-L1 to Squamous Cell Carcinoma After Treatment With Alectinib Open
We report an anaplastic lymphoma kinase (ALK)-positive patient shows a poor response to the ALK inhibitor alectinib due to the high expression of programmed death-ligand 1 (PD-L1). After treatment with alectinib, the pathological form chan…
View article: Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans Open
View article: Missense Variant of Endoplasmic Reticulum Region of <i>WFS1</i> Gene Causes Autosomal Dominant Hearing Loss without Syndromic Phenotype
Missense Variant of Endoplasmic Reticulum Region of <i>WFS1</i> Gene Causes Autosomal Dominant Hearing Loss without Syndromic Phenotype Open
Objective . Genetic variants in the WFS1 gene can cause Wolfram syndrome (WS) or autosomal dominant nonsyndromic low‐frequency hearing loss (HL). This study is aimed at investigating the molecular basis of HL in an affected Chinese family …
View article: Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans
Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans Open
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel coronavirus causing an outbreak of COVID-19 globally in the past six months. A relatively higher divergence on the spike protein of SASR-CoV-2 enables it to transmit a…
View article: The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD)
The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD) Open