Explanipedia

Prodrug nanoassembly technology for colorectal cancer therapy Open

Qing Wang, Shiyi Zuo, Xiaoling Yang, Yaqi Li, Cuiyun Liu , et al. · 2025

The clinical efficacy of Irinotecan is constrained by individual variability in its enzymatic conversion to the active metabolite, SN38. While direct administration of SN38 bypasses this enzymatic process and demonstrates potent anti-tumor…

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD Open

Claire D. Clelland, Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad R. Altobelli , et al. · 2025

Genetic mutations in the progranulin gene, GRN , cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant ( GRN +…

Undecidability of Polynomial Inequalities in Subset Densities and Additive Energies Open

Yaqiao Li · 2025

Many results in extremal graph theory can be formulated as certain polynomial inequalities in graph homomorphism densities. Answering fundamental questions raised by Lov{á}sz, Szegedy and Razborov, Hatami and Norine proved that determining…

Diversity-seeking swap games in networks Open

Yaqiao Li, Lata Narayanan, Jaroslav Opatrný, Yi Xu · 2025

Schelling games use a game-theoretic approach to study the phenomenon of residential segregation as originally modeled by Schelling. Inspired by the recent increase in the number of people and businesses preferring and promoting diversity,…

Renting Servers for Multi-Parameter Jobs in the Cloud Open

Yaqiao Li, Mahtab Masoori, Lata Narayanan, Denis Pankratov · 2025

Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea Open

Maryna V. Ivanchenko, Kevin T. Booth, K. Domenica Karavitaki, Larisa M. Antonellis, M. Aurel Nagy , et al. · 2024

Mutations in the GJB2 gene cause the most common form of human hereditary hearing loss, known as DFNB1. GJB2 is expressed in two cell groups of the cochlea—epithelial cells of the organ of Corti and fibrocytes of the inner sulcus and later…

PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models Open

Maryna V. Ivanchenko, Daniel M. Hathaway, Eric M. Mulhall, Kevin T. Booth, Mantian Wang , et al. · 2024

Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and progressive blindness in the form of retinitis pigmentosa. In this study, we ex…

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury Open

C Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li , et al. · 2024

Background Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that reducing acetylated ta…

Rational engineering of cholesterol-modified prodrug nanoassemblies for improving the tumor selectivity and safety of mitoxantrone Open

Bowen Zhang, Wenyuan Liu, Jinrui Liu, Minglong Huang, Yaqiao Li , et al. · 2024

Mitoxantrone (MTO) is an anthraquinone antitumor drug with potent therapeutic benefits. However, its clinical application is restricted by the severe side effects stemming from poor tumor selectivity. In this study, MTO and cholesterol (CL…

Newman's theorem via Carathéodory Open

Ali Mohammad Lavasani, Yaqiao Li, Mehran Shakerinava · 2024

We give a streamlined short proof of Newman's theorem in communication complexity by applying the classical and the approximate Carathéodory's theorems.

Renting Servers for Multi-Parameter Jobs in the Cloud Open

Yaqiao Li, Mahtab Masoori, Lata Narayanan, Denis Pankratov · 2024

We study the Renting Servers in the Cloud problem (RSiC) in multiple dimensions. In this problem, a sequence of multi-parameter jobs must be scheduled on servers that can be rented on-demand. Each job has an arrival time, a finishing time,…

Streptomyces umbrella toxin particles block hyphal growth of competing species Open

Qinqin Zhao, Savannah K. Bertolli, Young‐Jun Park, Yongjun Tan, Kevin J. Cutler , et al. · 2024

Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive 1 . The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with othe…

Erratum to: Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs Open

Yuanhao Yu, Shiyi Zuo, Jiaxuan Song, Lingxiao Li, Tian Liu , et al. · 2024

The Hoechst and DOX tunnel images of the DOX-C 22 ANPs group at 4 h in Fig. 4(a) were mistakenly used with the neighboring images of DOX-C 26 ANPs group.The images were corrected as follows to be correspondence with the accurate merged ima…

Leveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights Open

Alice Tang, Katherine P. Rankin, Gabriel Cerono, Silvia Miramontes, Hunter Mills , et al. · 2024

Identification of Alzheimer’s disease (AD) onset risk can facilitate interventions before irreversible disease progression. We demonstrate that electronic health records from the University of California, San Francisco, followed by knowled…

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss Open

Grant Kauwe, Kristeen A. Pareja‐Navarro, Lei Yao, Jackson H. Chen, Ivy Tsz-Lo Wong , et al. · 2024

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer's disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated prot…

On the Online Weighted Non-Crossing Matching Problem Open

Joan Boyar, Shahin Kamali, Kim S. Larsen, Ali Mohammad Lavasani, Yaqiao Li , et al. · 2024

We introduce and study the weighted version of an online matching problem in the Euclidean plane with non-crossing constraints: 2n points with non-negative weights arrive online, and an algorithm can match an arriving point to one of the u…

Revealing The Impact Of Modified Modules Flexibility on Gemcitabine Prodrug Nanoassemblies for Effective Cancer Therapy Open

Jiayu Guo, Xiaoxiao Zhang, Fudan Dong, Simeng Wang, Danping Wang , et al. · 2024

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species Open

Qinqin Zhao, Savannah K. Bertolli, Young‐Jun Park, Yongjun Tan, Kevin J. Cutler , et al. · 2023

The Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive. The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with oth…

Predictive Modeling Leveraging Electronic Health Records Identifies Early Predictors of Alzheimer’s Disease Open

Alice Tang, Katherine P. Rankin, Gabriel Cerano, Silvia Miramontes, Hunter Mills , et al. · 2023

Background Alzheimer’s Disease (AD) is a neurodegenerative disorder of aging that is difficult to diagnose. Electronic health records (EHR) are a valuable source of longitudinal data for disease phenotyping and prediction. Knowledge graphs…

Transcriptomic Profiling Across Age, APOE and Sex for Models of Alzheimer’s Disease at a Single Cell Resolution Open

Yaqiao Li, Yanxia Hao, Seo Yeon Yoon, Brian P. Grone, Leonardo Ding , et al. · 2023

Background Advanced age, apolipoprotein E4(APOE4), and female sex are well‐established risk factors for Alzheimer’s Disease(AD). Almost two‐thirds of people with AD are women. The APOE4 genotype, the strongest genetic risk factor for AD, i…

Lifting query complexity to time-space complexity for two-way finite automata Open

Shenggen Zheng, Yaqiao Li, Minghua Pan, Jozef Gruska, Lvzhou Li · 2023

Time-space tradeoff has been studied in a variety of models, such as Turing machines, branching programs, and finite automata, etc. While communication complexity as a technique has been applied to study finite automata, it seems it has no…

PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F Open

Maryna V. Ivanchenko, Daniel M. Hathaway, Eric M. Mulhall, Kevin T. Booth, Mantian Wang , et al. · 2023

Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and progressive blindness in the form of retinitis pigmentosa. In this study, we ex…

Sex-stratified phenotyping of comorbidities associated with an inpatient delirium diagnosis using real world data Open

Lay Kodama, Sarah Woldemariam, Alice Tang, Yaqiao Li, Tomiko Oskotsky , et al. · 2023

Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to…

Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle Open

Yaxi Wang, Larry A. Gallagher, Pia A. Andrade, Andi Liu, Ian R. Humphreys , et al. · 2023

Patescibacteria, also known as the candidate phyla radiation (CPR), are a diverse group of bacteria that constitute a disproportionately large fraction of microbial dark matter. Its few cultivated members, belonging mostly to Saccharibacte…

Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species Open

Yaxi Wang, Hannah E. Ledvina, Catherine A. Tower, Stanimir Kambarev, Elizabeth Liu , et al. · 2023

Glutathione (GSH) is an abundant metabolite within eukaryotic cells that can act as a signal, a nutrient source, or serve in a redox capacity for intracellular bacterial pathogens. For Francisella, GSH is thought to be a critical in vivo s…

Online Vector Bin Packing and Hypergraph Coloring Illuminated: Simpler Proofs and New Connections Open

Yaqiao Li, Denis Pankratov · 2023

This paper studies the online vector bin packing (OVBP) problem and the related problem of online hypergraph coloring (OHC). Firstly, we use a double counting argument to prove an upper bound of the competitive ratio of $FirstFit$ for OVBP…

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss Open

Grant Kauwe, Kristeen A. Pareja‐Navarro, Lei Yao, Jackson H. Chen, Ivy Tsz-Lo Wong , et al. · 2023

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we define a mechanism for plasticity repair in vulnerable …

Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F Open

Cole W. Peters, Killian S. Hanlon, Maryna V. Ivanchenko, Eric Zinn, Elizabeth Linarte , et al. · 2023

Perspective on complexity measures targetting read-once branching programs Open

Yaqiao Li, Pierre McKenzie · 2023

A model of computation for which reasonable yet still incomplete lower bounds are known is the read-once branching program. Here variants of complexity measures successful in the study of read-once branching programs are defined and studie…

Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter Open

Yaxi Wang, Larry A. Gallagher, Pia A. Andrade, Andi Liu, Ian R. Humphreys , et al. · 2023

Summary The study of bacteria has yielded fundamental insights into cellular biology and physiology, biotechnological advances and many therapeutics. Yet due to a lack of suitable tools, the significant portion of bacterial diversity held …

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