Yaroslav Ilnytskyy
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View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma
A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma Open
Glioblastoma is the most common primary brain tumor in adults. Our previous studies revealed a functional interplay of myelin transcription factor 1-like (MYT1L) with the DNA-dependent protein kinase (DNA-PK) in the regulation of p21 trans…
View article: Genetic and Epigenetic Changes in Arabidopsis thaliana Exposed to Ultraviolet-C Radiation Stress for 25 Generations
Genetic and Epigenetic Changes in Arabidopsis thaliana Exposed to Ultraviolet-C Radiation Stress for 25 Generations Open
Continuous exposure to stress contributes to species diversity and drives microevolutionary processes. It is still unclear, however, whether epigenetic changes, in the form of epimutations such as, for example, differential DNA methylation…
View article: Transcriptome of Arabidopsis thaliana Plants Exposed to Human Parasites Cryptosporidium parvum and Giardia lamblia
Transcriptome of Arabidopsis thaliana Plants Exposed to Human Parasites Cryptosporidium parvum and Giardia lamblia Open
Pathogen infection in animals and plants is recognized in a relatively similar manner by the interaction of pattern recognition receptors on the host cell surface with pathogen-associated molecular patterns on the pathogen surface. Previou…
View article: Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations
Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations Open
Prenatal maternal stress (PNMS) determines lifetime mental and physical health. Here, we show in rats that PNMS has consequences for placental function and fetal brain development across four generations (F0-F3). Using a systems biology ap…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggestive of a role in guiding cellular differentiation. Here, we show that glycolytic flux i…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract
Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract Open
Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scienti…
View article: Genomic and Epigenomic Changes in the Progeny of Cold-Stressed Arabidopsis thaliana Plants
Genomic and Epigenomic Changes in the Progeny of Cold-Stressed Arabidopsis thaliana Plants Open
Plants are continuously exposed to various environmental stresses. Because they can not escape stress, they have to develop mechanisms of remembering stress exposures somatically and passing it to the progeny. We studied the Arabidopsis th…
View article: Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells Open
Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the development of drug resistance and multiple adverse effects remain comm…
View article: Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells Open
* See README file for the description of data files available in this repository 1. Study Description: Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumours, including…
View article: Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells Open
* See README file for the description of data files available in this repository 1. Study Description: Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumours, including…
View article: Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Open
Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
View article: Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Open
Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
View article: Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Open
Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast cancer cells develop drug resistance that usually leads to a relapse and worsening of prognosis. We have shown recently that epigenetic changes…
View article: Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Open
Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast cancer cells develop drug resistance that usually leads to a relapse and worsening of prognosis. We have shown recently that epigenetic changes…
View article: Application of Drug Efficiency Index Metric for Analysis of Post-Traumatic Stress Disorder and Treatment Resistant Depression Gene Expression Profiles
Application of Drug Efficiency Index Metric for Analysis of Post-Traumatic Stress Disorder and Treatment Resistant Depression Gene Expression Profiles Open
Post-traumatic stress disorder (PTSD) is a severe mental illness with grave social, political, economic, and humanitarian implications. To apply the principles of personalized omics-based medicine to this psychiatric problem, we implemente…
View article: Genome-wide Detection of Chimeric Transcripts in Early-stage Non-small Cell Lung Cancer
Genome-wide Detection of Chimeric Transcripts in Early-stage Non-small Cell Lung Cancer Open
The data presented in this study allow researchers to identify, select, and validate promising candidates for targeted clinical interventions.
View article: Scatter Irradiation of Rat Brain Triggers Sex- and Brain Region-Specific Changes in the Expression of Non-Coding RNA Fragments
Scatter Irradiation of Rat Brain Triggers Sex- and Brain Region-Specific Changes in the Expression of Non-Coding RNA Fragments Open
Non-coding RNA fragments (ncRFs) are small RNA fragments processed from non-coding RNAs (ncRNAs). ncRFs have various functions and are commonly tissue-specific, and their processing is altered by exposure to stress. Information about ncRFs…
View article: Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts
Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts Open
Cannabis sativa is one of the oldest cultivated plants. Many of the medicinal properties of cannabis are known, although very few cannabis-based formulations became prescribed drugs. Previous research demonstrated that cannabis varieties a…
View article: <i>Pten</i> regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina
<i>Pten</i> regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina Open
SUMMARY The retina is an exquisitely patterned tissue, with neuronal somata positioned at regular intervals to completely sample the visual field. Cholinergic amacrine cells are spectacular exemplars of precision, distributing in two radia…