Yaroslav Kolinko
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View article: Active Prompt Tuning Enables Gpt-40 To Do Efficient Classification Of Microscopy Images
Active Prompt Tuning Enables Gpt-40 To Do Efficient Classification Of Microscopy Images Open
Traditional deep learning-based methods for classifying cellular features in microscopy images require time- and labor-intensive processes for training models. Among the current limitations are major time commitments from domain experts fo…
View article: Autologous Mesenchymal Stromal Cells Immobilized in Plasma-Based Hydrogel for the Repair of Articular Cartilage Defects in a Large Animal Model
Autologous Mesenchymal Stromal Cells Immobilized in Plasma-Based Hydrogel for the Repair of Articular Cartilage Defects in a Large Animal Model Open
The treatment of cartilage defects in trauma injuries and degenerative diseases represents a challenge for orthopedists. Advanced mesenchymal stromal cell (MSC)-based therapies are currently of interest for the repair of damaged cartilage.…
View article: Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology
Using virtual microscopy for the development of sampling strategies in quantitative histology and design‐based stereology Open
Only a fraction of specimens under study are usually selected for quantification in histology. Multilevel sampling or tissue probes, slides and fields of view (FOVs) in the regions of interest (ROIs) are required. In general, all parts of …
View article: Stereological Changes in Microvascular Parameters in Hippocampus of a Transgenic Rat Model of Alzheimer’s Disease
Stereological Changes in Microvascular Parameters in Hippocampus of a Transgenic Rat Model of Alzheimer’s Disease Open
Background: Microcirculatory factors play an important role in amyloid-β (Aβ)-related neuropathology in Alzheimer’s disease (AD). Transgenic (Tg) rat models of mutant Aβ deposition can enhance our understanding of this microvascular pathol…
View article: Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration
Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration Open
The aim of the study was to develop an orthopedic implant coating in the form of vancomycin-loaded collagen/hydroxyapatite layers (COLHA+V) that combine the ability to prevent bone infection with the ability to promote enhanced osseointegr…
View article: Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction
Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction Open
In liver surgery, biliary obstruction can lead to secondary biliary cirrhosis, a life-threatening disease with liver transplantation as the only curative treatment option. Mesenchymal stromal cells (MSC) have been shown to improve liver fu…
View article: Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice
Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice Open
View article: Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice
Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice Open
Background Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the assessment of health …
View article: Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice
Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice Open
Background Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the assessment of health …
View article: Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice
Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice Open
Background: Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the assessment of health…
View article: Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice
Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice Open
Background: Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the assessment of health…
View article: P4‐044: THERAPEUTIC POTENTIAL OF INNATE IMMUNITY STIMULATION BY CLASS B CPG ODN IN A TAUOPATHY MOUSE MODEL, RTG4510
P4‐044: THERAPEUTIC POTENTIAL OF INNATE IMMUNITY STIMULATION BY CLASS B CPG ODN IN A TAUOPATHY MOUSE MODEL, RTG4510 Open
Immunomodulation holds promise as an effective treatment for Alzheimer's Disease (AD). Our previous study in 3xTg-AD mice with both Aβ and tau pathologies, demonstrated that immunostimulation of innate immunity with TLR9 agonist CpG ODN ha…
View article: A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment
A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment Open
We believe that PCL nanofibers on their own can cause enough fibroplasia to be used as a separate material without the polypropylene base, thus avoiding potential adverse effects caused by any added substances.
View article: A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment
A polypropylene mesh modified with poly-ε-caprolactone nanofibers in hernia repair: large animal experiment Open
Barbora East,1,2 Martin Plencner,3,4 Martin Kralovic,1,3,5 Michala Rampichova,3 Vera Sovkova,1,3,5 Karolina Vocetkova,1,3,5 Martin Otahal,6,7 Zbynek Tonar,8,9 Yaroslav Kolinko,8,9 Evzen Amler,1,3,5 Jiri Hoch1,10 1Second Medical Faculty, Ch…
View article: Smaller Absolute Quantities but Greater Relative Densities of Microvessels Are Associated with Cerebellar Degeneration in Lurcher Mice
Smaller Absolute Quantities but Greater Relative Densities of Microvessels Are Associated with Cerebellar Degeneration in Lurcher Mice Open
Degenerative affections of nerve tissues are often accompanied by changes of vascularization. In this regard, not much is known about hereditary cerebellar degeneration. In this study, we compared the vascularity of the individual cerebell…
View article: Mutation-related differences in exploratory, spatial, and depressive-like behavior in pcd and Lurcher cerebellar mutant mice
Mutation-related differences in exploratory, spatial, and depressive-like behavior in pcd and Lurcher cerebellar mutant mice Open
The cerebellum is not only essential for motor coordination but is also involved in cognitive and affective processes. These functions of the cerebellum and mechanisms of their disorders in cerebellar injury are not completely understood. …