Yashad Dongol
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View article: Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels
Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels Open
Conotoxins are disulfide-rich peptides isolated from the venoms of marine cone snails. These natural products have inspired the development of several drug candidates and novel therapeutic leads. In addition to disulfide bonds, many conoto…
View article: Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues
Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues Open
A detailed SAR study led to two potent Ca V 2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), and strong potency.
View article: <i>N</i>-Sulfonylphenoxazines as neuronal calcium ion channel blockers
<i>N</i>-Sulfonylphenoxazines as neuronal calcium ion channel blockers Open
A series of N -sulfonylphenoxazines were synthesised and tested for Ca V 2.2 and Ca V 3.2 ion channel inhibition. Compounds with low micromolar activity for Ca V 2.2 had good plasma stability and liver microsomal stability, and favourable …
View article: Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes
Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes Open
The structure-function and optimization studies of Na V -inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing Na V 1.7. With several Na V subtypes emerging as potential therapeutic targets, s…
View article: Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid
Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid Open
Given the important role of voltage-gated sodium (Na V ) channel-modulating spider toxins in elucidating the function, pharmacology, and mechanism of action of therapeutically relevant Na V channels, we screened the venom from Australian t…
View article: Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways
Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways Open
Voltage-gated sodium channels (NaVs) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit NaV channels have helped unravel the role of NaV channels in diseases, including chronic …
View article: Prevalence of helicobacter pylori infection in patients with peptic ulcer disease at Kathmandu Model Hospital
Prevalence of helicobacter pylori infection in patients with peptic ulcer disease at Kathmandu Model Hospital Open
Introduction: Endoscopic rapid urease test is a simple and most widely used test to detect the presence of urease in the gastric mucosa. Many studies have reported prevalence of H. pylori infection in relation to age, gender and site of ul…
View article: Antimicrobial Sensitivity Trend in Blood Culture Positive Enteric Fever at Kathmandu Model Hospital
Antimicrobial Sensitivity Trend in Blood Culture Positive Enteric Fever at Kathmandu Model Hospital Open
Background: For diagnosis of enteric fever, the culture of the organism from different body fluids is the gold standard. After diagnosis, it is important to treat with the right antibiotic before any complications can occur. The retrospect…
View article: Antimicrobial Sensitivity Trend in Blood Culture Positive Enteric Fever
Antimicrobial Sensitivity Trend in Blood Culture Positive Enteric Fever Open
Background: For diagnosis of enteric fever, the culture of the organism from different body fluids is the gold standard. After diagnosis, it is important to treat with the right antibiotic before any complications can occur. The retrospect…
View article: Transabdominal Pre-peritoneal Mesh Repair versus Lichtenstein’s Hernioplasty
Transabdominal Pre-peritoneal Mesh Repair versus Lichtenstein’s Hernioplasty Open
Background: In the era of minimal invasive surgery, hernia repair has seen a paradigm shift from open to laparoscopic technique. However, superiority of laparoscopic repair over open repair is still controversial. Available literatures hav…
View article: Transabdominal Pre-peritoneal Mesh Repair versus Lichtenstein’s Hernioplasty
Transabdominal Pre-peritoneal Mesh Repair versus Lichtenstein’s Hernioplasty Open
Background: In the era of minimal invasive surgery, hernia repair has seen a paradigm shift from open to laparoscopic technique. However, superiority of laparoscopic repair over open repair is still controversial. Available literatures hav…
View article: Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation Open
Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of…
View article: Effectiveness of Spinal Anaesthesia versus General Anaesthesia for Open Cholecystectomy
Effectiveness of Spinal Anaesthesia versus General Anaesthesia for Open Cholecystectomy Open
\nBackground: Cholecystectomy is performed either as an open or a laparascopic route. Despite of a number of peri-operative and post-operative benefits of laparascopic cholecystectomy, the traditional and invasive open cholecystectomy is s…
View article: The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA 2 – NN-XIb-PLA 2 of Indian cobra venom
The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA 2 – NN-XIb-PLA 2 of Indian cobra venom Open
View article: Effectiveness of Intrathecal Morphine for Analgesia following Elective Caesarean Section
Effectiveness of Intrathecal Morphine for Analgesia following Elective Caesarean Section Open
Aims: This study evaluates the effectiveness of usage of 0.2 mg intrathecal morphine as post-operative analgesia and its effect on activity of mother after elective cesarean section. Methods: This hospital based prospective, randomized, do…
View article: Near-miss Obstetric Events in a Tertiary Care Teaching Hospital in Nepal: An Audit
Near-miss Obstetric Events in a Tertiary Care Teaching Hospital in Nepal: An Audit Open
Aims: This study aims to determine the frequency of near-miss obstetric events and analyze its nature such as reasons for near-miss, organ dysfunction associated and critical management required among pregnant women managed over a 3-year p…
View article: Prophylactic administration of ondansetron in prevention of intrathecal morphine-induced pruritus and post-operative nausea and vomiting in patients undergoing caesarean section
Prophylactic administration of ondansetron in prevention of intrathecal morphine-induced pruritus and post-operative nausea and vomiting in patients undergoing caesarean section Open