Yasin Panahi
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View article: Multimodal urinary biomarker panel achieves superior prostate cancer detection accuracy and reduces unnecessary biopsies
Multimodal urinary biomarker panel achieves superior prostate cancer detection accuracy and reduces unnecessary biopsies Open
To address the persistent challenges associated with prostate-specific antigen (PSA) screening, a multicenter study was conducted to evaluate whether urinary microRNAs, in combination with the free-to-total PSA (f/tPSA) ratio, could improv…
View article: Children exposed to salt-dust emission from Urmia Lake have short telomere length: a case-control pilot study
Children exposed to salt-dust emission from Urmia Lake have short telomere length: a case-control pilot study Open
This study aimed to measure telomere length in healthy children living next to Urmia Lake, Iran, which is exposed to salt dust from a drying lakebed. In this case-control pilot study, we recruited 39 sex- and age-matched healthy children f…
View article: Acquisition of Doxorubicin Resistance Induces Breast Cancer Cell Migration and Epithelial-Mesenchymal Transition that are Reversed by Shikonin-Metformin Synergy
Acquisition of Doxorubicin Resistance Induces Breast Cancer Cell Migration and Epithelial-Mesenchymal Transition that are Reversed by Shikonin-Metformin Synergy Open
Background: Drug resistance is a major challenge in cancer chemotherapy. Methods: By adopting an appropriately timed strategy, we generated MCF-7 cell sublines resistant to serial doses of doxorubicin (DOX). Our higher-dose sublines showed…
View article: Synthesis, evaluation of the cytotoxicity, apoptosis induction in AGS cell line and gene expression and molecular modeling studies of novel tetrahydropyrimidine derivatives
Synthesis, evaluation of the cytotoxicity, apoptosis induction in AGS cell line and gene expression and molecular modeling studies of novel tetrahydropyrimidine derivatives Open
Cancer is a complex disease that remains a leading cause of death worldwide owing to the lack of effective and efficient drugs. Compounds known as tetrahydropyrmidine have shown great potential as anti-cancer agents. Here, novel compounds …
View article: Detection of Metastatic Breast Cancer from Whole-Slide Pathology Images Using an Ensemble Deep-Learning Method
Detection of Metastatic Breast Cancer from Whole-Slide Pathology Images Using an Ensemble Deep-Learning Method Open
Background: Metastasis is the main cause of death toll among breast cancer patients. Since current approaches for diagnosis of lymph node metastases are time-consuming, deep learning (DL) algorithms with more speed and accuracy are explore…
View article: Can Anti-Parasitic Drugs Help Control COVID-19?
Can Anti-Parasitic Drugs Help Control COVID-19? Open
Novel COVID-19 is a public health emergency that poses a serious threat to people worldwide. Given the virus spreading so quickly, novel antiviral medications are desperately needed. Repurposing existing drugs is the first strategy. Anti-p…
View article: Association Study between DUF1220 Copy Number and Severity of Social Impairment in Sex-balanced Simplex Autism
Association Study between DUF1220 Copy Number and Severity of Social Impairment in Sex-balanced Simplex Autism Open
It seems that association of DUF1220 CNV with the severity of symptoms in simplex children with autism may follow a sexually dimorphic pattern that needs to be re-examined in prospective studies.
View article: Differential Levels of Telomeric Oxidized Bases and TERRA Transcripts in Childhood Autism
Differential Levels of Telomeric Oxidized Bases and TERRA Transcripts in Childhood Autism Open
A bstract The underlying molecular mechanisms responsible for the etiology of autism and its sex-biased prevalence remain largely elusive. Abnormally shortened telomeres have recently been associated with autism. We have previously shown t…
View article: Sexual Dimorphism in Telomere Length in Childhood Autism
Sexual Dimorphism in Telomere Length in Childhood Autism Open
Autism spectrum disorders (ASD) are lifelong heterogeneous set of neurodevelopmental conditions with strikingly profound male prevalence. Differences in sex biology and hormones are thought to play key roles in ASD prevalence and outcome, …
View article: Accurate Detection of Breast Cancer Metastasis Using a Hybrid Model of Artificial Intelligence Algorithm
Accurate Detection of Breast Cancer Metastasis Using a Hybrid Model of Artificial Intelligence Algorithm Open
Background: Breast cancer (BC) is a prevalent disease and a major cause of mortality among women worldwide. A substantial number of BC patients experience metastasis which in turn leads to treatment failure and death. The survival rate has…
View article: Accurate Detection of Breast Cancer Metastasis Using a Hybrid Model of Artificial Intelligence Algorithm
Accurate Detection of Breast Cancer Metastasis Using a Hybrid Model of Artificial Intelligence Algorithm Open
Background: Breast cancer (BC) is a prevalent disease and a major cause of mortality among women worldwide. A substantial number of BC patients experience metastasis which in turn leads to treatment failure and death. The survival rate has…
View article: Selection of Suitable Reference Genes for Analysis of Salivary Transcriptome in Non-Syndromic Autistic Male Children
Selection of Suitable Reference Genes for Analysis of Salivary Transcriptome in Non-Syndromic Autistic Male Children Open
Childhood autism is a severe form of complex genetically heterogeneous and behaviorally defined set of neurodevelopmental diseases, collectively termed as autism spectrum disorders (ASD). Reverse transcriptase quantitative real-time PCR (R…