Yasmin Hilliam
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View article: Induction of lipid A modification genes in Pseudomonas aeruginosa cells tolerant to a commercially available contact lens disinfection solution
Induction of lipid A modification genes in Pseudomonas aeruginosa cells tolerant to a commercially available contact lens disinfection solution Open
Graphical abstract Pseudomonas aeruginosa survival in a commercially available contact lens disinfection solution is increased by exposure to sub-inhibitory concentrations of the solution via induction of lipid A modification pathways. Cre…
View article: Respiratory viral infection is associated with increased <i>Pseudomonas</i> abundance in cystic fibrosis airways
Respiratory viral infection is associated with increased <i>Pseudomonas</i> abundance in cystic fibrosis airways Open
Acute respiratory viral infections are an important driver of morbidity and mortality in people with chronic lung disease and are frequently associated with pulmonary exacerbations and a transition from intermittent to chronic bacterial in…
View article: Resistance and tolerance of Pseudomonas aeruginosa to contact lens disinfection solutions
Resistance and tolerance of Pseudomonas aeruginosa to contact lens disinfection solutions Open
View article: RNA-seq reproducibility of <i>Pseudomonas aeruginosa</i> in laboratory models of cystic fibrosis
RNA-seq reproducibility of <i>Pseudomonas aeruginosa</i> in laboratory models of cystic fibrosis Open
Reproducibility is a fundamental expectation in science and enables investigators to have confidence in their research findings and the ability to compare data from disparate sources, but evaluating reproducibility can be elusive. For exam…
View article: Cystic fibrosis pathogens persist in the upper respiratory tract following initiation of elexacaftor/tezacaftor/ivacaftor therapy
Cystic fibrosis pathogens persist in the upper respiratory tract following initiation of elexacaftor/tezacaftor/ivacaftor therapy Open
Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in C…
View article: Persistence and evolution of <i>Pseudomonas aeruginosa</i> following initiation of highly effective modulator therapy in cystic fibrosis
Persistence and evolution of <i>Pseudomonas aeruginosa</i> following initiation of highly effective modulator therapy in cystic fibrosis Open
Today, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is wide…
View article: Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis
Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis Open
Background While the widespread initiation of elexacaftor/tezacaftor/ivacaftor (ETI) has led to dramatic clinical improvements among persons with cystic fibrosis (pwCF), little is known about how ETI affects the respiratory mucosal inflamm…
View article: Elexacaftor–tezacaftor–ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis
Elexacaftor–tezacaftor–ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis Open
Background Chronic rhinosinusitis (CRS) is common in individuals with cystic fibrosis (CF) and is marked by chronic inflammation and episodes of infection that negatively impact quality of life. Several studies have shown that elexacaftor–…
View article: Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection
Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection Open
Viral-bacterial coinfections of the respiratory tract have long been associated with worsened disease outcomes. Clinical and basic research studies demonstrate that these infections are driven via complex interactions between the infecting…
View article: Transcriptome KEGG pathways
Transcriptome KEGG pathways Open
KEGG pathways as assigned to differentially expressed genes using eggNOG-mapper.
View article: Genes with differential expression (sample C3 removed)
Genes with differential expression (sample C3 removed) Open
Genes with differential expression in pre-treated vs. control conditions (sample C3 removed)
View article: Genes with differential expression
Genes with differential expression Open
Genes with differential expression in pre-treated vs. control conditions (sample C3 removed)
View article: Proteome KEGG pathways
Proteome KEGG pathways Open
KEGG pathways as assigned to proteomic data using eggNOG-mapper.
View article: UKMOG keratitis Pseudomonas aeruginosa isolate list
UKMOG keratitis Pseudomonas aeruginosa isolate list Open
Information on the origins of UGMOG keratitis isolates used in this study
View article: Proteins with differential abundance (sample C5 removed)
Proteins with differential abundance (sample C5 removed) Open
All proteins identified has having differential abundance between pre-treated and control conditions.
View article: <i>Pseudomonas aeruginosa</i>adaptation and diversification in the non-cystic fibrosis bronchiectasis lung
<i>Pseudomonas aeruginosa</i>adaptation and diversification in the non-cystic fibrosis bronchiectasis lung Open
To characterise Pseudomonas aeruginosa populations during chronic lung infections of non-cystic fibrosis bronchiectasis patients, we used whole-genome sequencing to 1) assess the diversity of P. aeruginosa and the prevalence of multilineag…
View article: Genotyping of Pseudomonas aeruginosa isolates from pulmonary infections in non-cystic fibrosis bronchiectasis patients
Genotyping of Pseudomonas aeruginosa isolates from pulmonary infections in non-cystic fibrosis bronchiectasis patients Open
Non-cystic fibrosis bronchiectasis (NCFBr) is a chronic, progressive respiratory disease characterised by irreversible widening of the airways and thickening of the bronchial walls. There have been large amounts of research into cystic fib…