Yasmin Nouri
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View article: IMMU-41. Investigating Multi-Targeting CAR T Cells to Overcome Heterogeneity in Adult Glioblastoma
IMMU-41. Investigating Multi-Targeting CAR T Cells to Overcome Heterogeneity in Adult Glioblastoma Open
High-grade gliomas (HGGs) exhibit significant intra- and inter-tumoral heterogeneity, posing a major challenge for chimeric antigen receptor (CAR) T cell therapies that target a single antigen. Multi-targeting CAR T cells offer a promising…
View article: EXTH-75. Precision Immunotherapy for Paediatric High-Grade Glioma: PDGFRα CAR T Cells Show Potent Activity in a Rare Patient-Derived Model
EXTH-75. Precision Immunotherapy for Paediatric High-Grade Glioma: PDGFRα CAR T Cells Show Potent Activity in a Rare Patient-Derived Model Open
Paediatric high-grade gliomas (pHGG) remain among the most lethal childhood cancers, and the subset of H3K27M-wild-type diffuse gliomas is especially under-studied due to a lack of representative models. Here, we describe a rare, clinicall…
View article: Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer
Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer Open
High-grade gliomas (HGGs), including glioblastoma (GBM) and pediatric diffuse midline gliomas (DMGs), remain highly fatal despite therapeutic advances. The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a …
View article: TIRE-seq simplifies transcriptomics via integrated RNA capture and library preparation
TIRE-seq simplifies transcriptomics via integrated RNA capture and library preparation Open
RNA sequencing (RNA-seq) is widely used in biomedical research, advancing our understanding of gene expression across biological systems. Traditional methods require upstream RNA extraction from biological inputs, adding time and expense t…
View article: TIRE-seq: an Integrated Sample Extraction and Transcriptomics Workflow for High Throughput Perturbation Studies
TIRE-seq: an Integrated Sample Extraction and Transcriptomics Workflow for High Throughput Perturbation Studies Open
RNA sequencing (RNA-seq) is widely used in biomedical research, advancing our understanding of gene expression across biological systems. Traditional methods require upstream RNA extraction from biological inputs, adding time and expense t…
View article: An <i>In Vitro</i> Model to Assess CRS Potential of CAR T Cells Using a Tumor Cell Line and Autologous Monocytes
An <i>In Vitro</i> Model to Assess CRS Potential of CAR T Cells Using a Tumor Cell Line and Autologous Monocytes Open
Chimeric antigen receptor (CAR) T cell therapy is an engineered cell therapy where T cells are isolated and genetically modified to contain a synthetic CAR with specificity to a tumor cell antigen. Upon antigen binding, the CAR T cell will…
View article: Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking
Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking Open
Germline inactivating variants of CDH1 are causative of hereditary diffuse gastric cancer (HDGC), a cancer syndrome characterized by an increased risk of both diffuse gastric cancer and lobular breast cancer. Because loss of function mutat…
View article: T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells
T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells Open
Toll-like receptors (TLRs) are evolutionarily conserved molecules that specifically recognize common microbial patterns, and have a critical role in innate and adaptive immunity. Although TLRs are highly expressed by innate immune cells, p…
View article: Hereditary diffuse gastric cancer: updated clinical practice guidelines
Hereditary diffuse gastric cancer: updated clinical practice guidelines Open
View article: Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells Open
The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for hereditary diffuse gastric cancer syndrome (HDGC). Usi…