Yasuhiko Tabata
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View article: A Novel Peptide-Anchoring Method to Functionalize Gelatin Hydrogels with Antibodies via a Noncovalent Interaction
A Novel Peptide-Anchoring Method to Functionalize Gelatin Hydrogels with Antibodies via a Noncovalent Interaction Open
Gelatin hydrogels are widely used in biomedical applications, such as tissue engineering and drug delivery. However, the efficient incorporation of antibodies into gelatin hydrogels remains challenging because conventional cross-linking me…
View article: Novel family of near-room-temperature compensated itinerant pyrochlore ferrimagnets, $R{\mathrm{In}}{\mathrm{Co}}_{4}$ ($R=$ Dy-Tm)
Novel family of near-room-temperature compensated itinerant pyrochlore ferrimagnets, $R{\mathrm{In}}{\mathrm{Co}}_{4}$ ($R=$ Dy-Tm) Open
We successfully synthesized single crystals of a series of C15b Laves phase compounds, $R{\mathrm{In}}{\mathrm{Co}}_{4}$ ($R=$ Dy-Tm), with Co-pyrochlore and $R$-fcc sublattices, and systematically studied their magnetic properties via mag…
View article: Biocompatibility and bioactivity of gelatin hydrogel sponges incorporating bioactive glasses capable of controlled release of basic fibroblast growth factor
Biocompatibility and bioactivity of gelatin hydrogel sponges incorporating bioactive glasses capable of controlled release of basic fibroblast growth factor Open
This study aimed to evaluate the in vivo biocompatibility and bioactivity of gelatin hydrogel sponges incorporating bioactive glasses (BG), with or without impregnation of basic fibroblast growth factor (bFGF), as a potential scaffold for …
View article: Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models
Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models Open
Canine MSC derived EVs cultured in serum-free medium using AEX were successfully collected. Sustained release of canine MSC derived EVs suppresses cavity formation in the spinal cord after SCI and promotes improvement in motor function.
View article: A novel approach for hepatocyte transplantation at the liver surface
A novel approach for hepatocyte transplantation at the liver surface Open
Hepatocyte transplantation (HTx) is a promising alternative to liver transplantation; however, poor engraftment remains a major challenge. Although co-transplantation with adipose tissue-derived stromal cells (ADSCs) or islets improves eng…
View article: A novel method of pancreatic islet transplantation at the liver surface using a gelatin hydrogel nonwoven fabric
A novel method of pancreatic islet transplantation at the liver surface using a gelatin hydrogel nonwoven fabric Open
Considering the limitations of intraportal transplantation (Tx), we sought to establish an alternative approach for it—transplanting islets onto the liver surface (LS) by optimizing adipose tissue-derived stem cell (ADSC) co-Tx procedures …
View article: Novel method to prevent severe postoperative pancreatic fistula caused by lipolysis
Novel method to prevent severe postoperative pancreatic fistula caused by lipolysis Open
Background Although several prophylactic strategies have been developed for postoperative pancreatic fistula (POPF), research on its severe form is few. Recently, it has been reported that severe POPF can be caused by intraabdominal lipoly…
View article: Physicochemical properties of gelatin/hyaluronic acid printed hydrogel and incorporated with thymoquinone: In Vitro evaluation of biocompatibility for wound healing
Physicochemical properties of gelatin/hyaluronic acid printed hydrogel and incorporated with thymoquinone: In Vitro evaluation of biocompatibility for wound healing Open
Wound healing is a multifaceted biological process that necessitates the development of advanced materials that can effectively support tissue regeneration and repair. The fabrication of bioengineered wound dressings has evolved significan…
View article: Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation
Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation Open
The objective of this study is to evaluate the effect of hydrogen gas on the biological functions of human adipose-derived stem cells (hADSC) in cryopreservation. hADSC were cryopreserved by a commercial cell preservation solution in the p…
View article: Enhancement of tracheal cartilage regeneration by local controlled release of stromal cell-derived factor 1α with gelatin hydrogels and systemic administration of high-mobility group box 1 peptide
Enhancement of tracheal cartilage regeneration by local controlled release of stromal cell-derived factor 1α with gelatin hydrogels and systemic administration of high-mobility group box 1 peptide Open
The present study demonstrated that combination therapy with gelatin hydrogel incorporating SDF-1α and HMGB1 peptide injected intravenously can enhance the recruitment of CXCR4-positive MSC, promoting the regeneration of damaged tracheal c…
View article: Isolation of plant-derived exosome-like nanoparticles (PDENs) from Solanum nigrum L. berries and Their Effect on interleukin-6 expression as a potential anti-inflammatory agent
Isolation of plant-derived exosome-like nanoparticles (PDENs) from Solanum nigrum L. berries and Their Effect on interleukin-6 expression as a potential anti-inflammatory agent Open
Inflammation is a temporary response of the immune system that can be treated using common anti-inflammatory drugs. However, prolonged use of these drugs increases the risk of adverse side effects. Accordingly, there is an increasing need …
View article: Toll-like receptor 3-stimulation and aggregate-formation synergistically enhances anti-inflammatory activity of feline mesenchymal stem cells
Toll-like receptor 3-stimulation and aggregate-formation synergistically enhances anti-inflammatory activity of feline mesenchymal stem cells Open
TLR3-stimulated, bFGF-pretreated fAdMSC aggregates increase the anti-inflammatory activity significantly, providing a potential therapeutic approach for inflammatory diseases in felines.
View article: A Gelatin Hydrogel Nonwoven Fabric Combined With Adipose Tissue–Derived Stem Cells Enhances Subcutaneous Islet Engraftment
A Gelatin Hydrogel Nonwoven Fabric Combined With Adipose Tissue–Derived Stem Cells Enhances Subcutaneous Islet Engraftment Open
Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet e…
View article: A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats
A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats Open
Although subcutaneous islet transplantation has many advantages, the subcutaneous space is poor in vessels and transplant efficiency is still low in animal models, except in mice. Subcutaneous islet transplantation using a two-step approac…
View article: Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells
Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells Open
Ideal regeneration of hard tissue and dental pulp has been reported with the use of a combination of bioactive glass and basic fibroblast growth factor (bFGF). However, no previous study has investigated the molecular mechanisms underlying…
View article: A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats
A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats Open
Although subcutaneous islet transplantation has many advantages, transplant efficiency is still low in animal models, except in mice. We previously reported the efficacy of pretreatment using gelatin hydrogel nonwoven fabric (GHNF) in a mo…
View article: Comparisons of the effects of silk elastin and collagen sponges on wound healing in murine models
Comparisons of the effects of silk elastin and collagen sponges on wound healing in murine models Open
Silk elastin sponges demonstrated superior neoepithelialization and angiogenesis compared to collagen sponges. The results suggest that silk elastin and collagen sponges promote wound healing through different mechanisms, with silk elastin…
View article: Osteogenic induction of asiatic acid derivatives in human periodontal ligament stem cells
Osteogenic induction of asiatic acid derivatives in human periodontal ligament stem cells Open
Asiatic acid (AA) and asiaticoside, pentacyclic triterpenoid compounds derived from Centella asiatica, are known for their biological effects in promoting type I collagen synthesis and inducing osteogenesis of stem cells. However, their ap…
View article: A gelatin hydrogel nonwoven fabric improves outcomes of subcutaneous islet transplantation
A gelatin hydrogel nonwoven fabric improves outcomes of subcutaneous islet transplantation Open
Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously reported that a recombinant peptide (RCP) enhances subcutaneous islet engraftment. However, it…
View article: Association with cationized gelatin nanospheres enhances cell internalization of mitochondria efficiency
Association with cationized gelatin nanospheres enhances cell internalization of mitochondria efficiency Open
The objective of this study is to confirm the methodological feasibility of cationized gelatin nanospheres (cGNS) to enhance the internalization efficiency of mitochondria (Mt) isolated to cells for their increasing functions. The cGNS wer…
View article: Gelatin–chitosan–cellulose nanocrystals as an acellular scaffold for wound healing application: fabrication, characterisation and cytocompatibility towards primary human skin cells
Gelatin–chitosan–cellulose nanocrystals as an acellular scaffold for wound healing application: fabrication, characterisation and cytocompatibility towards primary human skin cells Open
Biopolymers that mimic the extracellular matrix are favourable in tissue engineering. However, the rapid degradation and the lack of mechanical and enzymatic stabilities of these biopolymers prompt researchers to composite different biopol…
View article: Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications
Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications Open
Wound contracture, which commonly happens after wound healing, may lead to physical distortion, including skin constriction. Therefore, the combination of collagen and elastin as the most abundant extracellular matrix (ECM) skin matrices m…
View article: The Transfer of the Hepatocyte Growth Factor Gene by Macrophages Ameliorates the Progression of Peritoneal Fibrosis in Mice
The Transfer of the Hepatocyte Growth Factor Gene by Macrophages Ameliorates the Progression of Peritoneal Fibrosis in Mice Open
Growing evidence indicates that hepatocyte growth factor (HGF) possesses potent antifibrotic activity. Furthermore, macrophages migrate to inflamed sites and have been linked to the progression of fibrosis. In this study, we utilized macro…
View article: Matrix vesicles promote bone repair after a femoral bone defect in mice
Matrix vesicles promote bone repair after a femoral bone defect in mice Open
Matrix vesicles (MtVs) are one of the extracellular vesicles (EVs) secreted by osteoblasts. Although MtVs have a classically-defined function as an initiator of ossification and recent findings suggest a role for MtVs in the regulation of …
View article: Modified gelatin hydrogel nonwoven fabrics (Genocel) as a skin substitute in murine skin defects
Modified gelatin hydrogel nonwoven fabrics (Genocel) as a skin substitute in murine skin defects Open
Genocel-L has a lower water content and slower degradation rate than the conventional Genocel. Genocel-L had equivalent efficacy as a skin substitute to Pelnac, and can therefore be considered feasible for use as a skin substitute. However…
View article: <scp>CD169</scp><sup>+</sup> sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer
<span>CD169</span><sup>+</sup> sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer Open
Aims Mismatch‐repair deficiency and microsatellite instability‐high (dMMR/MSI‐H) colorectal cancer (CRC) is treated with programmed death (PD)‐1 antibody regardless of PD‐ligand (L)1 expression in tumor cells. We previously found that abun…