Yasuhiro Itsui
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View article: Elucidation of the needs for telecritical care services in Japan: a qualitative study
Elucidation of the needs for telecritical care services in Japan: a qualitative study Open
Objective To clarify the reasons for consultation, advice sought by frontline physicians and relationship between the patient’s pathology and the type of advice provided to guide the future development of telecritical care services. Design…
View article: Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study
Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study Open
Higher grit scores were associated with lower odds of having depressive symptoms among residents at the timing of job start during the COVID-19 pandemic. Regular mental health assessment is particularly important for residents with low gri…
View article: Changes in Nutrition-Intake Method and Oral Health through a Multidisciplinary Team Approach in Malnourished Older Patients Admitted to an Acute Care Hospital
Changes in Nutrition-Intake Method and Oral Health through a Multidisciplinary Team Approach in Malnourished Older Patients Admitted to an Acute Care Hospital Open
Malnourished older inpatients referred to a nutrition support team (NST) usually receive multidisciplinary oral health management during NST intervention. However, the effects of multidisciplinary oral health management on the nutrition-in…
View article: Factors Related to Oral Intake of Food by Hospitalized Patients with Malnutrition under the Care of a Nutrition Support Team
Factors Related to Oral Intake of Food by Hospitalized Patients with Malnutrition under the Care of a Nutrition Support Team Open
This study aimed to evaluate the role of the general condition and oral health status in determining the primary nutritional route and suitable food form for oral ingestion among malnourished inpatients. This cross-sectional study included…
View article: Facilitators and barriers to physicians’ entrepreneurial ventures in major Japanese cities: A qualitative study
Facilitators and barriers to physicians’ entrepreneurial ventures in major Japanese cities: A qualitative study Open
Background The Japanese healthcare system currently faces numerous challenges, including a super-aging society and an excessive burden on medical workers; therefore, the need for innovative solutions from healthcare ventures to tackle thes…
View article: Nutritional Supports for Joy of Eating and Tasting
Nutritional Supports for Joy of Eating and Tasting Open
がん患者は,がんの部位や治療・病期の進行・筋力低下などさまざまな理由により嚥下障害が生じ,食事摂取困難に陥ることがある.がん患者にとって,食事摂取量は術後感染症予防や治療完遂,生存率に重要であることが知られている一方,嚥下障害による食事摂取困難は,体重減少・低栄養・サルコペニアの原因となり,患者の生活の質(quality of life:QOL)低下につながる可能性がある.食事は栄養補給としての意味合いだけではなく,心理的な満足感にも大きく関係しているため,嚥下障害があるが…
View article: Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts Open
Formation of intrahepatic bile ducts (IHBDs) proceeds in accordance with their microenvironment. Particularly, mesenchymal cells around portal veins regulate the differentiation and ductular morphogenesis of cholangiocytes in the developin…
View article: Hypervirulent clade 2, ribotype 019/sequence type 67 Clostridioides difficile strain from Japan
Hypervirulent clade 2, ribotype 019/sequence type 67 Clostridioides difficile strain from Japan Open
Background Clostridioides difficile ribotype (RT) 019/sequence type (ST) 67 strains belong to a hypervirulent lineage closely related to RT027/ST1; however, limited data are available for hypervirulent clade 2 lineages in Japan. Herein, we…
View article: Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma
Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma Open
Aim The genetic profile of cholangiolocellular carcinoma (CLC) and its origin in relation to hepatocellular carcinoma (HCC) remain unclear. To elucidate the genetic profile of CLC, a comprehensive analysis of genetic mutations was carried …
View article: Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients Open
Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated the characteristics of the novel RASs observed in treatment-failure patients, A92K…
View article: LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells Open
Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepatocytes. Improvement of cell-cell interactions between epithelium a…
View article: A case of tracheal obstruction caused by reflux and aspiration of semi-solid nutrients via the nasogastric tube
A case of tracheal obstruction caused by reflux and aspiration of semi-solid nutrients via the nasogastric tube Open
Although semi-solid nutrients have several advantages, including reduced diarrhea and gastroesophageal reflux, evidence on semi-solid nutrients via the nasogastric tube is insufficient. It should be noted that semi-solid nutrient reflux ca…
View article: Supplementary Material for: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Supplementary Material for: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease Open
Background: The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. The aim of the present study was to identify such risk factors in NAFLD patients …
View article: Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System
Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System Open
A novel genotype 1b HCV cell culture was constructed with core amino acid substitutions, which demonstrated IFN resistance of genotype 1b. This system will be useful for future analyses into the mechanisms of HCV genotype 1b treatment.
View article: A case of hepatitis C virus-associated mixed cryoglobulinemia treated with direct-acting antivirals
A case of hepatitis C virus-associated mixed cryoglobulinemia treated with direct-acting antivirals Open
症例は79歳女性．25年前にC型慢性肝炎と診断され，その後クリオグロブリン関連腎症と診断された．C型肝炎ウイルス（HCV）排除とクリオグロブリン血症の改善のために様々なInterferon（IFN）-based therapyを行ったものの無効であった．今回，蛋白尿と腎機能の急性増悪から致死的な心不全を併発して入院した．体液コントロールとクリオグロブリン除去による蛋白尿改善を目的に血漿交換/血液透析併用療法を開始し，心不全と体液貯留が改善した後，daclatasvir/as…
View article: A case of primary sclerosing cholangitis with unique clinical features for a 5-year follow up
A case of primary sclerosing cholangitis with unique clinical features for a 5-year follow up Open
症例は26歳女性．2008年（21歳時）健康診断で肝機能障害を指摘され当科紹介受診となった．各種ウイルスおよび自己抗体は陰性で，BMI 25.1（152 cm/58 kg）と軽度肥満と，美容のためにビタミン剤などのサプリメント摂取歴を認めたことから食事運動療法および摂取サプリメントを中止し経過観察となったが，生活習慣の指導，肝庇護療法を開始した後もトランスアミナーゼは高値のまま推移した．2010年，2012年に施行した肝生検では確定診断には至らず，その後それまで限局性だった…