Yasuhiro Nakashima
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View article: Impact of hypogammaglobulinemia on bacterial infections after allogeneic hematopoietic cell transplantation
Impact of hypogammaglobulinemia on bacterial infections after allogeneic hematopoietic cell transplantation Open
Background : Infections are major complications in patients with hematologic neoplasms. Humoral immunity plays a critical role in defense against pathogens. Although hypogammaglobulinemia can carry a risk of infection, there is no confirme…
View article: KUS121, a novel VCP modulator, attenuates atherosclerosis development by reducing ER stress and inhibiting glycolysis through the maintenance of ATP levels in endothelial cells
KUS121, a novel VCP modulator, attenuates atherosclerosis development by reducing ER stress and inhibiting glycolysis through the maintenance of ATP levels in endothelial cells Open
KUS121 can be a new therapeutic option for atherosclerotic diseases by maintaining intracellular ATP levels, leading to the attenuation of ER stress and glycolysis in plaque endothelium.
View article: Suppressive effects of Levilactobacillus brevis on Fusarium-plant disease and its potential contribution to environmentally friendly agriculture
Suppressive effects of Levilactobacillus brevis on Fusarium-plant disease and its potential contribution to environmentally friendly agriculture Open
To harmonize with sustainable practices, chemical pesticide use is being reduced globally, and more farmers are adopting environmentally friendly agricultural methods. In this context, lactic acid bacteria (LAB) have garnered increasing at…
View article: Comments on Future Missions of Japanese Agricultural Economics
Comments on Future Missions of Japanese Agricultural Economics Open
View article: Advancing Sustainable Development Goals through Character Education and Social Studies in Japanese Schools
Advancing Sustainable Development Goals through Character Education and Social Studies in Japanese Schools Open
Character education is increasingly recognized as a critical component in developing individuals who are not only academically proficient but also possess strong moral and ethical values. This study examines the integration of social studi…
View article: Suppressive Effects of Levilactobacillus Brevis on Fusarium-Plant Disease and its Potential Contribution to Environmentally Friendly Agriculture
Suppressive Effects of Levilactobacillus Brevis on Fusarium-Plant Disease and its Potential Contribution to Environmentally Friendly Agriculture Open
View article: Startups Bridging Agricultural Science and Agriculture: Toward Ideal Collaboration
Startups Bridging Agricultural Science and Agriculture: Toward Ideal Collaboration Open
View article: T cells with high BCL-2 expression induced by venetoclax impact anti-leukemic immunity “graft-versus-leukemia effects”
T cells with high BCL-2 expression induced by venetoclax impact anti-leukemic immunity “graft-versus-leukemia effects” Open
View article: A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells
A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells Open
Background Endoplasmic reticulum (ER) stress signaling pathways have pivotal roles in atherosclerosis progression. Recently, we have developed Kyoto University Substance (KUS) 121, which selectively inhibits ATPase activities of valosin-co…
View article: Risk Assessment for Elderly Patients with Esophageal Cancer
Risk Assessment for Elderly Patients with Esophageal Cancer Open
View article: CRISPR-Cas9-guided amplification-free genomic diagnosis for familial hypercholesterolemia using nanopore sequencing
CRISPR-Cas9-guided amplification-free genomic diagnosis for familial hypercholesterolemia using nanopore sequencing Open
Familial hypercholesterolemia is an inherited disorder that remains underdiagnosed. Conventional genetic testing methods such as next-generation sequencing (NGS) or target PCR are based on the amplification process. Due to the efficiency l…
View article: The Influence of Production Environment Information on Rice Consumption Behavior of Ethically Oriented Consumers
The Influence of Production Environment Information on Rice Consumption Behavior of Ethically Oriented Consumers Open
This paper focuses on two types of information collected by new technologies, UAV (Unmanned Aerial Vehicle) and field sensors, and examines their influence on the evaluation of rice by ethically-minded consumers. It does so through taste e…
View article: Exploring the Relationship between Store Type Selection and Nutrient Intake
Exploring the Relationship between Store Type Selection and Nutrient Intake Open
The aim of this study is to elucidate the relationship between food purchasing behavior and the consumption of nutrients and various food groups. Our research focused on the influence of store format preferences on food purchasing behavior…
View article: The Network Structure of the Wholesale Market Systems in the Tohoku Region
The Network Structure of the Wholesale Market Systems in the Tohoku Region Open
This study investigated the network structure of the wholesale market systems in the Tohoku region, using a network analysis of transfer volumes for vegetables and fruits. Our analysis revealed that a network centered on the Sendai market …
View article: KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels
KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels Open
KUS121 ameliorated HF by a mechanism totally different from that of conventional catecholamines. We propose that KUS121 is a promising new option for the treatment of HF.
View article: B-054 Potential of Autotaxin in the Early Diagnosis of Sinusoidal Obstruction Syndrome after Allogeneic Hematopoietic Cell Transplantation
B-054 Potential of Autotaxin in the Early Diagnosis of Sinusoidal Obstruction Syndrome after Allogeneic Hematopoietic Cell Transplantation Open
Background Sinusoidal obstruction syndrome (SOS) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Early intervention leads to a good prognosis, but it is often difficult to differentiate SO…
View article: Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5
Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5 Open
Hematopoietic progenitors are enriched in the endocardial cushion and contribute, in a Nkx2-5-dependent manner, to tissue macrophages required for the remodeling of cardiac valves and septa. However, little is known about the molecular mec…
View article: Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis
Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis Open
Nonalcoholic steatohepatitis (NASH) can lead to cirrhosis and hepatocellular carcinoma in their advanced stages; however, there are currently no approved therapies. Here, we show that microRNA (miR)-33b in hepatocytes is critical for the d…
View article: Risk factors for <scp>CAR‐T</scp> cell manufacturing failure among <scp>DLBCL</scp> patients: A nationwide survey in Japan
Risk factors for <span>CAR‐T</span> cell manufacturing failure among <span>DLBCL</span> patients: A nationwide survey in Japan Open
Summary For successful chimeric antigen receptor T (CAR‐T) cell therapy, CAR‐T cells must be manufactured without failure caused by suboptimal expansion. In order to determine risk factors for CAR‐T cell manufacturing failure, we performed…
View article: Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation
Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation Open
We herein report a case of idiopathic refractory ascites following allogeneic hematopoietic cell transplantation that was successfully treated with ibrutinib. A 39-year-old man presented with massive transudative ascites. Despite a high po…
View article: Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report
Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report Open
CD19-directed chimeric antigen receptor (CAR) T-cell therapy has been widely used and highly effective for B-cell lymphoid malignancies. Immune-mediated adverse effects such as cytokine release syndrome (CRS) and immune effector cell-assoc…
View article: Impact of the State of Emergency Declarations for COVID-19 on Food Consumption
Impact of the State of Emergency Declarations for COVID-19 on Food Consumption Open
This study analyzed the impact of the state of emergency declarations for COVID-19 on food consumption using consumer purchase history data. We performed a regression discontinuity design using a random effect Tobit model. The main finding…
View article: Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report
Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report Open
CD19-directed chimeric antigen receptor (CAR) T-cell therapy has been widely used and highly effective for B-cell lymphoid malignancies. Immune-mediated adverse effects such as cytokine release syndrome (CRS) and immune effector cell-assoc…
View article: Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report
Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report Open
CD19-directed chimeric antigen receptor (CAR) T-cell therapy has been widely used and highly effective for B-cell lymphoid malignancies. Immune-mediated adverse effects such as cytokine release syndrome (CRS) and immune effector cell-assoc…
View article: Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation
Successful treatment of proven coronavirus disease 2019-associated pulmonary aspergillosis with liposomal amphotericin B in a patient with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation Open
View article: Phagocytosis of Mature Granulocytes by Bone Marrow Macrophages in an Elderly Man with Adult-Onset Primary Autoimmune Neutropenia
Phagocytosis of Mature Granulocytes by Bone Marrow Macrophages in an Elderly Man with Adult-Onset Primary Autoimmune Neutropenia Open
Adult-onset primary autoimmune neutropenia (AIN) is an extremely rare but sometimes life-threatening disease. Its pathophysiology is still to be clarified. We describe a case with adult-onset primary AIN with phagocytosis of mature granulo…
View article: Immunomodulatory and direct activities of ropeginterferon alfa‐2b on cancer cells in mouse models of leukemia
Immunomodulatory and direct activities of ropeginterferon alfa‐2b on cancer cells in mouse models of leukemia Open
Although ropeginterferon alfa‐2b has recently been clinically applied to myeloproliferative neoplasms with promising results, its antitumor mechanism has not been thoroughly investigated. Using a leukemia model developed in immunocompetent…
View article: Supplementary Material for: Safety and efficacy of blinatumomab in Japanese adult and pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: final results from an expansion cohort
Supplementary Material for: Safety and efficacy of blinatumomab in Japanese adult and pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia: final results from an expansion cohort Open
Background The safety and efficacy of blinatumomab, a CD19/CD3 BiTE® (bispecific T-cell engager) molecule, was evaluated in an expansion cohort of the phase 1b/2 study (NCT02412306) in Japanese adult (n=14) and pediatric (n=17) patients wi…
View article: A Prospective Study of an HLA-Haploidentical Peripheral Blood Stem Cell Transplantation Regimen Based on Modification of the Dose of Posttransplant Cyclophosphamide for Poor Prognosis or Refractory Hematological Malignancies
A Prospective Study of an HLA-Haploidentical Peripheral Blood Stem Cell Transplantation Regimen Based on Modification of the Dose of Posttransplant Cyclophosphamide for Poor Prognosis or Refractory Hematological Malignancies Open
The optimal dose of posttransplant cyclophosphamide (PTCy) for use in patients undergoing HLA-haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide (PTCy-haplo) has not been sufficiently examined. This stud…
View article: Correction to: Another usage of autotomized penis
Correction to: Another usage of autotomized penis Open