Yasushi Tanaka
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View article: Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes
Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes Open
Importance Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Des…
View article: Effect of Imeglimin on Microalbuminuria and Serum Vitamin B12 Concentration in Japanese Patients With Type 2 Diabetes
Effect of Imeglimin on Microalbuminuria and Serum Vitamin B12 Concentration in Japanese Patients With Type 2 Diabetes Open
View article: Association of Severe Sleep Apnoea in Patients with Primary Aldosteronism: A Cross-sectional Study Using the Oxygen Desaturation Index
Association of Severe Sleep Apnoea in Patients with Primary Aldosteronism: A Cross-sectional Study Using the Oxygen Desaturation Index Open
Objective: Sleep apnoea is frequently observed in patients with primary aldosteronism (PA), but the extent to which aldosterone excess contributes to sleep apnoea severity remains unclear. This study investigated the association between sl…
View article: A Reliable and Robust Method of Measuring Male Pelvic Floor Muscle Volume Using Three-dimensional Computed Tomography
A Reliable and Robust Method of Measuring Male Pelvic Floor Muscle Volume Using Three-dimensional Computed Tomography Open
Male PFMs could be selectively extracted using a workstation to reconstruct a stereoscopic image. The PFM volume measurement is feasible and highly reproducible. To our knowledge, this is the first study that standardizes the method for me…
View article: Correction: Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan
Correction: Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan Open
View article: Newly diagnosed ANCA-associated vasculitis after COVID-19 infection: a case report
Newly diagnosed ANCA-associated vasculitis after COVID-19 infection: a case report Open
View article: Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan
Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan Open
View article: Oral Semaglutide Induces Loss of Body Fat Mass Without Affecting Muscle Mass in Patients With Type 2 Diabetes
Oral Semaglutide Induces Loss of Body Fat Mass Without Affecting Muscle Mass in Patients With Type 2 Diabetes Open
The 24-week treatment with oral semaglutide ameliorated glycemic control with reduction of body fat but not muscle mass in Japanese patients with type 2 diabetes.
View article: Associations of phase angle obtained by bioelectrical impedance analysis with muscle mass and strength in Japanese patients with type 2 diabetes
Associations of phase angle obtained by bioelectrical impedance analysis with muscle mass and strength in Japanese patients with type 2 diabetes Open
The age-dependent decrease in muscle mass and function is known as sarcopenia. The risk of sarcopenia is higher in patients with diabetes, and assessment of muscle mass and function is especially important in patients with diabetes. Recent…
View article: PROBLEM AGGREGATION AND SOLUTION PROPOSAL FOR RATIONALIZATION OF MAINTENANCE FOR ROAD BRIDGES MANAGED BY MUNICIPALITIES IN HOKURIKU REGION
PROBLEM AGGREGATION AND SOLUTION PROPOSAL FOR RATIONALIZATION OF MAINTENANCE FOR ROAD BRIDGES MANAGED BY MUNICIPALITIES IN HOKURIKU REGION Open
市町村は多くのインフラを管理しているが,そのメンテナンスに苦労している.特に北陸地方のコンクリート構造物では,塩害やASRによる劣化が生じやすく,早急な対応が望まれる.このような背景を踏まえて本稿では,地元の大学・高専教員が連携して,市町村が管理する道路橋を対象にした,メンテナンスの合理化に向けた支援について論ずる.はじめに,新潟県上越地区・富山県・石川県・福井県の41市町に対してヒアリング調査を実施し,課題とニーズを抽出した.次に,これらを改善すべく,コンクリート橋に対す…
View article: Effects of Elobixibat in Patients with Diabetes and Concomitant Chronic Constipation: an 8-week, Prospective, Single-center, Single-arm Study
Effects of Elobixibat in Patients with Diabetes and Concomitant Chronic Constipation: an 8-week, Prospective, Single-center, Single-arm Study Open
View article: Correlation between blood ketones and exhaled acetone measured with a semiconducting gas sensor
Correlation between blood ketones and exhaled acetone measured with a semiconducting gas sensor Open
Breath acetone (BrAce) has been reported to be useful for monitoring the pathophysiology of patients with diabetes. However, devices that measure BrAce are expensive, complex and uncommon. The FM-001, originally designed to monitor a marke…
View article: Alanine Aminotransferase, Body Mass Index, and Hemoglobin A1c May Be Useful Markers for Monitoring Changes in Intrahepatic Lipid Content in Japanese Patients With Overweight or Obesity and Type 2 Diabetes
Alanine Aminotransferase, Body Mass Index, and Hemoglobin A1c May Be Useful Markers for Monitoring Changes in Intrahepatic Lipid Content in Japanese Patients With Overweight or Obesity and Type 2 Diabetes Open
Background: Intrahepatic lipid (IHL) content is considered as an important marker of insulin resistance in overweight and obesity, so quantifying IHL content may be useful for assessing effects of interventions. IHL content can be quantita…
View article: Remitting seronegative symmetrical synovitis with pitting edema: a case report
Remitting seronegative symmetrical synovitis with pitting edema: a case report Open
View article: A Claims Database Analysis of Dose-Dependency of Metformin and Incidence of Lactic Acidosis in Japanese Patients with Type 2 Diabetes
A Claims Database Analysis of Dose-Dependency of Metformin and Incidence of Lactic Acidosis in Japanese Patients with Type 2 Diabetes Open
The results suggest an association between metformin administration and the incidence of lactic acidosis, but an increase in the incidence rate of lactic acidosis was not observed in those patients receiving high-dose metformin compared to…
View article: Effects of Increasing Metformin Dose vs Adding/Switching to Dipeptidyl Peptidase-4 Inhibitors on Glycemic Control in Patients with Type 2 Diabetes
Effects of Increasing Metformin Dose vs Adding/Switching to Dipeptidyl Peptidase-4 Inhibitors on Glycemic Control in Patients with Type 2 Diabetes Open
View article: Risk of hypoglycemia in Japanese people with type 2 diabetes mellitus who initiated or switched to insulin glargine 300 U/mL: A subgroup analysis of 12-month post-marketing surveillance study (X-STAR study)
Risk of hypoglycemia in Japanese people with type 2 diabetes mellitus who initiated or switched to insulin glargine 300 U/mL: A subgroup analysis of 12-month post-marketing surveillance study (X-STAR study) Open
Our study found no apparent increase in the hypoglycemia risk in people with older age and renal impairment who were administered Gla-300. These results would provide reassuring information on Gla-300 use.
View article: Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement for 48 weeks in elderly patients with type 2 diabetes
Effects of resistance training using elastic bands on muscle strength with or without a leucine supplement for 48 weeks in elderly patients with type 2 diabetes Open
Type 2 diabetes is associated with sarcopenia. Resistance training and appropriate nutritional therapy are reported to be effective for muscle strength and mass. This study aimed to evaluate the effect of resistance training using elastic …
View article: Effect of Eating Glutinous Brown Rice Twice a Day for 6 Weeks on Serum 1,5-Anhydroglucitol in Japanese Subjects without Diabetes
Effect of Eating Glutinous Brown Rice Twice a Day for 6 Weeks on Serum 1,5-Anhydroglucitol in Japanese Subjects without Diabetes Open
We have previously demonstrated that eating glutinous brown rice (GBR) for 1 day or 8 weeks was well accepted and improved glycemic control in patients with type 2 diabetes. The present study evaluated whether eating GBR could also improve…
View article: Real-world data on the use of insulin glargine 300 U/mL in Japanese patients with type 1 diabetes: twelve-month results from a post-marketing surveillance study (X-STAR study)
Real-world data on the use of insulin glargine 300 U/mL in Japanese patients with type 1 diabetes: twelve-month results from a post-marketing surveillance study (X-STAR study) Open
Gla-300 showed no unprecedented safety concerns for insulin-experienced T1DM patients in Japanese clinical settings. Our results provide insights into strategies for blunted Gla-300 up-titration dose, despite insufficient HbA1c control and…
View article: Development of a simple prediction model for adrenal crisis diagnosis
Development of a simple prediction model for adrenal crisis diagnosis Open
To develop a prediction model for adrenal crisis (AC) diagnosis among individuals with adrenal insufficiency that relies on the values of routinely measured clinical parameters, for application in standard clinical practice. We retrospecti…
View article: Effectiveness and safety of insulin glargine 300 unit/mL in Japanese type 2 diabetes mellitus patients: a 12-month post-marketing surveillance study (X-STAR study)
Effectiveness and safety of insulin glargine 300 unit/mL in Japanese type 2 diabetes mellitus patients: a 12-month post-marketing surveillance study (X-STAR study) Open
Background With limited real-world insulin glargine 300 unit/mL (Gla-300) data available, we assessed the effectiveness and safety of Gla-300 in the Japanese type 2 diabetes mellitus (T2DM) population.Research design and methods X-STAR was…
View article: Characteristics of R-R intervals in patients with continuous atrial fibrillation and subsequent heart failure
Characteristics of R-R intervals in patients with continuous atrial fibrillation and subsequent heart failure Open
Introduction: Atrial fibrillation (AF) predisposes patients to heart failure (HF) and a resultant increase in mortality, however, little is known regarding what characteristics of AF are related to HF. Our aim is to clarify the characteris…
View article: Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study
Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study Open
Aims/Introduction Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long‐term treatments are available. Methods This was an investigator‐initiated multicenter prospective intervention study in whi…
View article: Integrated safety analysis of filgotinib treatment for rheumatoid arthritis from seven clinical trials
Integrated safety analysis of filgotinib treatment for rheumatoid arthritis from seven clinical trials Open
Background and Aim: Filgotinib (FIL), an oral, potent, selective JAK‐1 inhibitor, provided statistically significant and clinically meaningful improvement in rheumatoid arthritis (RA) signs and symptoms, physical function, radiographic pro…
View article: Effect of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin on Muscle Mass and the Muscle/Fat Ratio in Patients With Type 2 Diabetes
Effect of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin on Muscle Mass and the Muscle/Fat Ratio in Patients With Type 2 Diabetes Open
Sitagliptin 24-week treatment demonstrated not only reduction of body fat and liver fat but also an increase of muscle and muscle/fat ratio. These changes may partly explain the mechanism underlining sitagliptin-induced improvement of glyc…
View article: Effects of anagliptin on plasma glucagon levels and gastric emptying in patients with type 2 diabetes: An exploratory randomized controlled trial versus metformin
Effects of anagliptin on plasma glucagon levels and gastric emptying in patients with type 2 diabetes: An exploratory randomized controlled trial versus metformin Open
View article: Efficacy and Safety of Ipragliflozin in Patients With Type 2 Diabetes: ASSIGN-K Study
Efficacy and Safety of Ipragliflozin in Patients With Type 2 Diabetes: ASSIGN-K Study Open
Background: Sodium glucose cotransporter 2 (SGLT2) inhibitors achieve good glycemic control in patients with type 2 diabetes, as well as reducing body weight and blood pressure. However, no large-scale clinical studies of SGLT2 inhibi…
View article: Characteristics of Gut Microbiota in Patients With Diabetes Determined by Data Mining Analysis of Terminal Restriction Fragment Length Polymorphisms
Characteristics of Gut Microbiota in Patients With Diabetes Determined by Data Mining Analysis of Terminal Restriction Fragment Length Polymorphisms Open
We were able to classify the 16SrRNA gene amplification products obtained from fecal samples of T1D patients, T2D patients, and non-DM subjects with a high level of precision by combining T-RFLP analysis and data mining. Specific gut micro…
View article: Efficacy and Safety of Adding Sitagliptin in Type 2 Diabetes Patients on Insulin: Age-Stratified Comparison at One Year in the ASSIST-K Study
Efficacy and Safety of Adding Sitagliptin in Type 2 Diabetes Patients on Insulin: Age-Stratified Comparison at One Year in the ASSIST-K Study Open
Despite baseline differences in demographic factors and medications, sitagliptin showed good efficacy and safety in all age groups of patients receiving it as add-on therapy to insulin during routine management of T2DM. Adding sitagliptin …