Yasutaka Hoshino
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View article: Human Interleukin-4-Dependent Facilitation of Human IgG Production in PBL-NOG-hIL-4-Tg mice
Human Interleukin-4-Dependent Facilitation of Human IgG Production in PBL-NOG-hIL-4-Tg mice Open
Immune-humanized mice provide valuable experimental models for evaluating immune-based therapies, yet the induction of human antigen-specific IgG production remains limited due to species-specific incompatibilities. Our previous work demon…
View article: Perceptions of Medical Students’ Unprofessional Behaviors Among Faculty Members and Medical Students: A Cross-Sectional Study at a Japanese Medical School
Perceptions of Medical Students’ Unprofessional Behaviors Among Faculty Members and Medical Students: A Cross-Sectional Study at a Japanese Medical School Open
Both faculty members and medical students perceived the unprofessional behaviors of medical students similarly, except in the cases of bullying, discrimination, and sexual harassment. However, since faculty members considered five behavior…
View article: Whole-Genome Sequencing and Comparative Genomic Analysis of Three Clinical Bloodstream Infection Isolates of Trichosporon austroamericanum
Whole-Genome Sequencing and Comparative Genomic Analysis of Three Clinical Bloodstream Infection Isolates of Trichosporon austroamericanum Open
Trichosporon austroamericanum is a recently described yeast species related to Trichosporon inkin and exclusively isolated from clinical specimens. However, its genomic features and pathogenic potential remain poorly understood. In this st…
View article: Microbiological Characteristics and Drug Resistance Rates of <i>Candida auris</i> Isolates in Japan
Microbiological Characteristics and Drug Resistance Rates of <i>Candida auris</i> Isolates in Japan Open
Candida auris was initially isolated from a Japanese patient, and is now an emerging fungus species owing to its long-term colonization capabilities and high resistance to antifungal drugs. However, the domestic epidemiology of C. auris in…
View article: Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection
Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection Open
Histoplasmosis is caused by Histoplasma capsulatum and is prevalent in areas of the world where H. capsulatum is endemic. We herein report a patient diagnosed with human immunodeficiency virus-1 (HIV-1) who developed histoplasmosis from a …
View article: Pulmonary Nocardiosis Due to <i>Nocardia exalbida</i> Infection Following Living-donor Liver Transplantation
Pulmonary Nocardiosis Due to <i>Nocardia exalbida</i> Infection Following Living-donor Liver Transplantation Open
Nocardia exalbida, an uncommon Nocardia, was first identified in 2006. We herein report a 70-year-old man with pulmonary nocardiosis caused by N. exalbida after living-donor liver transplantation. We also review 11 previously reported case…
View article: Surgical Resection to Treat a Japanese Patient with Pulmonary Coccidioidomycosis
Surgical Resection to Treat a Japanese Patient with Pulmonary Coccidioidomycosis Open
Coccidioidomycosis is an endemic disease that is particularly prevalent in the United States. However, its geographic distribution is becoming widespread. Here, we present a Japanese male who resided in the United States for 1 year, where …
View article: P364 Quantitative monitoring of <i>Aspergillus fumigatus</i> mycelial growth by optical density
P364 Quantitative monitoring of <i>Aspergillus fumigatus</i> mycelial growth by optical density Open
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Filamentous fungi generally form hyphal pellets in liquid culture. This property prevents filamentous fungi from applying the growth monitoring methods used for unicellula…
View article: Aureobasidium melanigenum catheter-related bloodstream infection: a case report
Aureobasidium melanigenum catheter-related bloodstream infection: a case report Open
View article: Factors Associated with Breakthrough Fungemia Caused by <i>Candida</i> , <i>Trichosporon</i> , or Fusarium Species in Patients with Hematological Disorders
Factors Associated with Breakthrough Fungemia Caused by <i>Candida</i> , <i>Trichosporon</i> , or Fusarium Species in Patients with Hematological Disorders Open
Limited data are available on breakthrough fungemia, defined as fungemia that develops on administration of antifungal agents, in patients with hematological disorders. We reviewed the medical and microbiological records of adult patients …
View article: Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density
Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density Open
Filamentous fungi generally form hyphal pellets in liquid culture. This property prevents filamentous fungi to apply the methods used for unicellular organisms such as yeast and bacteria.
View article: Examination of Cyp51A-Mediated Azole Resistance in <i>Aspergillus lentulus</i> Using CRISPR/Cas9 Genome Editing
Examination of Cyp51A-Mediated Azole Resistance in <i>Aspergillus lentulus</i> Using CRISPR/Cas9 Genome Editing Open
Aspergillus lentulus was first reported in 2005 as a cryptic species of Aspergillus fumigatus, and since then, its resistance to azole drugs and the high mortality rate of infected individuals have emerged as problems. Although it has been…
View article: Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notG
Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notG Open
Nocardithiocin is a thiopeptide compound produced by the pathogenic actinomycete Nocardia pseudobrasiliensis that displays activity against Gram-positive bacteria including drug-resistant Mycobacterium tuberculosis. However, the clinical u…
View article: Identification of a Novel Variant Form of <i>Aspergillus fumigatus</i> CalC and Generation of Anti-CalC Monoclonal Antibodies
Identification of a Novel Variant Form of <i>Aspergillus fumigatus</i> CalC and Generation of Anti-CalC Monoclonal Antibodies Open
Aspergillus fumigatus is a critical human fungal pathogen that infects the host via inhalation of airborne conidia. These conidia then germinate to form filamentous hyphae, which secrete various elements to survive in the host lung.Element…
View article: Aspergillus fumigatus CalCの新規変異型の同定と抗CalCモノクローナル抗体の生成
Aspergillus fumigatus CalCの新規変異型の同定と抗CalCモノクローナル抗体の生成 Open
View article: Insight into the draft whole-genome sequence of the dermatophyte Arthroderma vanbreuseghemii
Insight into the draft whole-genome sequence of the dermatophyte Arthroderma vanbreuseghemii Open
View article: CRISPR/Cas9 Genome Editing To Demonstrate the Contribution of Cyp51A Gly138Ser to Azole Resistance in Aspergillus fumigatus
CRISPR/Cas9 Genome Editing To Demonstrate the Contribution of Cyp51A Gly138Ser to Azole Resistance in Aspergillus fumigatus Open
A pan-azole-resistant Aspergillus fumigatus strain with the cyp51A mutations Gly138Ser and Asn248Lys was isolated from a patient receiving long-term voriconazole treatment. PCR fragments containing cyp51A with the mutations were introduced…
View article: Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in <i>Aspergillus fumigatus</i>
Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in <i>Aspergillus fumigatus</i> Open
Azole resistance in Aspergillus fumigatus is predominantly associated with increased expression of Cyp51A (lanosterol 14α-demethylase), the target enzyme of azole antifungal agents, or with single-nucleotide polymorphisms (SNPs) in cyp51A …
View article: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment
Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment Open
View article: Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic
Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic Open
The two currently available live oral rotavirus vaccines, Rotarix(®) and RotaTeq(®), are highly efficacious in the developed countries. However, the efficacy of such vaccines in resource deprived countries in Africa and Southeast Asia is l…
View article: Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains
Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains Open