Yasutaka Tobe
YOU?
Author Swipe
View article: Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening
Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening Open
Intracranial aneurysms (IAs) affect about 3% of the population, often leading to catastrophic outcomes upon rupture. Vasa vasorum, microvessels supplying arterial walls, are conjectured to induce inflammation and leakage in IAs that drive …
View article: AI-based modality-agnostic classification system for vascular calcifications
AI-based modality-agnostic classification system for vascular calcifications Open
View article: Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences
Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences Open
BACKGROUND Intracranial aneurysm (IA) wall remodeling remains a critical yet poorly understood process despite extensive research into clinical, morphological, and hemodynamic determinants of IA formation, growth, and rupture. This study a…
View article: Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures
Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures Open
View article: Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall
Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall Open
The role of the vasa vasorum in the growth and rupture of intracranial aneurysms, as well as the conditions stimulating its local development along aneurysm walls are not completely clear and have not been studied on an aneurysm‐specific b…
View article: Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures
Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures Open
View article: Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions
Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions Open
Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterization of hemodynamic conditions within the IA walls and their influence on bleb development, aiming to enhance…
View article: Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in <scp>ACom</scp> and <scp>MCA</scp> aneurysms
Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in <span>ACom</span> and <span>MCA</span> aneurysms Open
The mechanisms behind intracranial aneurysm formation and rupture are not fully understood, with factors such as location, patient demographics, and hemodynamics playing a role. Additionally, the significance of anatomical features like bl…
View article: Quantifying Smooth Muscles Regional Organization in the Rat Bladder Using Immunohistochemistry, Multiphoton Microscopy and Machine Learning
Quantifying Smooth Muscles Regional Organization in the Rat Bladder Using Immunohistochemistry, Multiphoton Microscopy and Machine Learning Open
The smooth muscle bundles (SMBs) in the bladder act as contractile elements which enable the bladder to void effectively. In contrast to skeletal muscles, these bundles are not highly aligned, rather they are oriented more heterogeneously …
View article: Highlights from Microscopy and Microanalysis
Highlights from Microscopy and Microanalysis Open
View article: Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy
Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy Open
Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies su…
View article: Three-dimensional wall-thickness distributions of unruptured intracranial aneurysms characterized by micro-computed tomography
Three-dimensional wall-thickness distributions of unruptured intracranial aneurysms characterized by micro-computed tomography Open
Aneurysmal rupture is associated with wall thinning, but the mechanism is poorly understood. This study aimed to characterize the three-dimensional wall-thickness distributions of unruptured intracranial aneurysms. Five aneurysmal tissues …
View article: Phenotyping calcification in vascular tissues using artificial intelligence
Phenotyping calcification in vascular tissues using artificial intelligence Open
Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clin…
View article: O-049 Endothelial inflammation induced by vortex flow in patient-derived 3D intracranial aneurysm models
O-049 Endothelial inflammation induced by vortex flow in patient-derived 3D intracranial aneurysm models Open
Objective Computational fluid dynamics (CFD) has implicated aberrant flow stress in the pathophysiology of intracranial aneurysms. However, the direct causation of endothelial inflammatory response by aberrant flow stress in human aneurysm…
View article: Co-mapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy
Co-mapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy Open
Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies su…
View article: Prediction of bleb formation in intracranial aneurysms using machine learning models based on aneurysm hemodynamics, geometry, location, and patient population
Prediction of bleb formation in intracranial aneurysms using machine learning models based on aneurysm hemodynamics, geometry, location, and patient population Open
Background Bleb presence in intracranial aneurysms (IAs) is a known indication of instability and vulnerability. Objective To develop and evaluate predictive models of bleb development in IAs based on hemodynamics, geometry, anatomical loc…
View article: Combining data from multiple sources to study mechanisms of aneurysm disease: Tools and techniques
Combining data from multiple sources to study mechanisms of aneurysm disease: Tools and techniques Open
Introduction Connecting local hemodynamics, biomechanics, and tissue properties in cerebral aneurysms is important for understanding the processes of wall degeneration and subsequent aneurysm progression and rupture. This challenging probl…
View article: Investigation on the cerebral aneurysm initiation mechanism by comparing the morphological characteristics of cerebral arteries on patients and healthy volunteers
Investigation on the cerebral aneurysm initiation mechanism by comparing the morphological characteristics of cerebral arteries on patients and healthy volunteers Open
View article: Pathological engineering study of wall thickness and mural cell in unruptured and ruptured human aneurysm to investigate the rupture mechanism in human cerebral aneurysm.
Pathological engineering study of wall thickness and mural cell in unruptured and ruptured human aneurysm to investigate the rupture mechanism in human cerebral aneurysm. Open
View article: Investigation of wall thinning mechanisms in human cerebral aneurysms by pathological engineering analysis of smooth muscle cells and hemodynamics
Investigation of wall thinning mechanisms in human cerebral aneurysms by pathological engineering analysis of smooth muscle cells and hemodynamics Open
View article: Study of the relationship between cerebrovascular blood flow supply and cerebral blood flow demand in ischemia patients and healthy humans
Study of the relationship between cerebrovascular blood flow supply and cerebral blood flow demand in ischemia patients and healthy humans Open
View article: 2E15 Patho-engineering analysis of human cerebral aneurysms : Study on the relationship of foam cell distribution and wall properties
2E15 Patho-engineering analysis of human cerebral aneurysms : Study on the relationship of foam cell distribution and wall properties Open
Foam cells are caused by excessive infiltration of lipid into the artery wall. In the current cerebral aneurysm study the presence of lipids has been shown in the aneurysm wall. However association of foam cells in the aneurysm wall has no…
View article: 2E13 Patho-engineering Analysis of Human Cerebral Aneurysms : Study on Thinning Mechanism by infrastructure
2E13 Patho-engineering Analysis of Human Cerebral Aneurysms : Study on Thinning Mechanism by infrastructure Open
This research investigated the properties of endothelial cells and wall structure of unruptured cerebral aneurysms to aim elucidation of cerebral aneurysm growth mechanism. Seven aneurysms were categorized into blood blister-like (under 80…
View article: 1E35 Development of visualization method for flow field around aortic valve model with stereo PIV
1E35 Development of visualization method for flow field around aortic valve model with stereo PIV Open
Computational fluid-structure interaction (FSI) is a technique that can analyze the flow filed with the deformable channel. The methodology is an effective technique to reveal the blood flow around aortic valve with large deformation. On t…
View article: 2E14 Patho-engineering analysis of human unruptured cerebral aneurysms : Study of the tissue healing mechanisms by mural cell densities
2E14 Patho-engineering analysis of human unruptured cerebral aneurysms : Study of the tissue healing mechanisms by mural cell densities Open
This research investigated mural cell densities in different wall thickness of five human unruptured cerebral aneurysms to evaluate the tissue healing ability of aneurysmal wall. Five aneurysms were dissected after craniotomy with markings…
View article: 2E11 Study of the blood flow characteristics of vessel models from healthy volunteers at the favorite site of cerebral aneurysms
2E11 Study of the blood flow characteristics of vessel models from healthy volunteers at the favorite site of cerebral aneurysms Open
There have not been any preceding research which refer to the relationship between morphological characteristics of cerebral artery and risks of cerebral aneurysm initiation from the perspective of blood flow. The objective of this researc…
View article: 2A14 Investigation of a relationship between hemodynamics and initiation of cerebral aneurysms : CFD analysis using an aneurysmal removal
2A14 Investigation of a relationship between hemodynamics and initiation of cerebral aneurysms : CFD analysis using an aneurysmal removal Open
View article: A110 Relationship between flow patterns and intimal structure of human cerebral aneurysms at blood-blister like lesion
A110 Relationship between flow patterns and intimal structure of human cerebral aneurysms at blood-blister like lesion Open
View article: 2A11 Study of relationship between hemodynamics and mural cells in thinning and thickening wall of human unruptured cerebral aneurysms
2A11 Study of relationship between hemodynamics and mural cells in thinning and thickening wall of human unruptured cerebral aneurysms Open
View article: 2A12 Comparison of hemodynamics and infrastructure of human cerebral aneurysms
2A12 Comparison of hemodynamics and infrastructure of human cerebral aneurysms Open