Yatao Wang
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View article: Spatial transcriptomics and scRNA-seq: decoding tumor complexity and constructing prognostic models in colorectal cancer
Spatial transcriptomics and scRNA-seq: decoding tumor complexity and constructing prognostic models in colorectal cancer Open
The findings highlight the critical role of tumor cell heterogeneity in CRC progression and treatment response, suggesting the need for personalized therapeutic strategies targeting different subpopulations. The constructed PS demonstrates…
View article: Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation <i>via</i> cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling
Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation <i>via</i> cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling Open
BACKGROUND Hepatocellular carcinoma (HCC) ranks among the most prevalent and deadly malignancies, characterized by a high recurrence rate. Regulator of chromosome condensation 1 (RCC1) serves as a principal guanine nucleotide exchange fact…
View article: 3-Deoxysappanchalcone attenuates LPS-induced neuroinflammation in microglia cell culture and ameliorates cognitive impairment in traumatic brain injury
3-Deoxysappanchalcone attenuates LPS-induced neuroinflammation in microglia cell culture and ameliorates cognitive impairment in traumatic brain injury Open
Background As one of the major public health security problems, traumatic brain injury (TBI) is characterized by cerebral dysfunction. The following neuroinflammation is considered as the main secondary injury factor. Targeting the express…
View article: RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells
RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells Open
Colorectal cancer (CRC) ranks as the third most frequently diagnosed cancer and is the second leading cause of cancer-related deaths globally. Recently, RNA-binding protein 39(RBM39), a critical factor in tumor-targeted mRNA and protein ex…
View article: Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization Open
Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases. However, the untapped mechanisms and new targets that c…
View article: Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin
Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin Open
Metformin (MET) is a commonly used drug for the treatment of type 2 diabetes in the department of endocrinology. In recent years, due to the few clinically effective treatment options including glioma, some scholars have proposed the possi…
View article: Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain
Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain Open
Astrocytes are associated with varying brain size between rodents and primates. As a close evolutionary relative of primates, the tree shrew ( Tupaia belangeri) provides a valuable comparative model for investigating glial architecture. Ho…
View article: Mechanism analysis and targeted therapy of IDH gene mutation in glioma
Mechanism analysis and targeted therapy of IDH gene mutation in glioma Open
Isocitrate dehydrogenase (IDH) is a pivotal enzyme responsible for catalyzing the oxidative decarboxylation of isocitrate into α-ketoglutarate (α-KG). This enzyme serves as a crucial regulator in the tricarboxylic acid cycle (TCA cycle), a…
View article: Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000–2023
Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000–2023 Open
Background Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, …
View article: Microscopic and neuroendoscopic treatment of a large ruptured supratentorial dermoid cyst with extensive dissemination: a case report and literature review
Microscopic and neuroendoscopic treatment of a large ruptured supratentorial dermoid cyst with extensive dissemination: a case report and literature review Open
Introduction and importance Intracranial dermoid cysts are rare, constituting 0.04% to 0.6% of all intracranial tumors. They often arise from ectodermal cells trapped during neural tube formation. We report a case of spontaneous rupture of…
View article: Microwave-Assisted Combustion Synthesized Sm2Co17 Magnetic Particles for Permanent Magnetic Application
Microwave-Assisted Combustion Synthesized Sm2Co17 Magnetic Particles for Permanent Magnetic Application Open
We reported the new synthesis of Sm2Co17 particles by a microwave-assisted combustion (MACS) method. This process enables the controlled decomposition of Sm(NO3)3 and Co(NO3)2 into SmCo-O particles, followed by calcium reduction-diffusion.…
View article: PhI(OAc)2-Promoted 1,2-Transfer Reaction between 1,1-Disubstituted Allylic Alcohols and Thiophenols
PhI(OAc)2-Promoted 1,2-Transfer Reaction between 1,1-Disubstituted Allylic Alcohols and Thiophenols Open
The PhI(OAc)2-promoted 1,2-transfer reaction between allylic alcohols and thiophenols, conducted in an argon atmosphere, has proven to be effective in producing β-carbonyl sulfides from 1,1-disubstituted allylic alcohols in high yields. Th…
View article: Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Cyclin-Dependent Kinase for Cancer Therapy
Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Cyclin-Dependent Kinase for Cancer Therapy Open
The regulation of the cancer cell cycle heavily relies on cyclin-dependent kinases (CDKs). Targeting CDKs has been identified as a promising approach for effective cancer therapy. In recent years, there has been significant attention paid …
View article: Synthetic Routes and Clinical Application of Representative Small-Molecule EGFR Inhibitors for Cancer Therapy
Synthetic Routes and Clinical Application of Representative Small-Molecule EGFR Inhibitors for Cancer Therapy Open
The epidermal growth factor receptor (EGFR) plays a pivotal role in cancer therapeutics, with small-molecule EGFR inhibitors emerging as significant agents in combating this disease. This review explores the synthesis and clinical utilizat…
View article: Mapping knowledge of the stem cell in traumatic brain injury: a bibliometric and visualized analysis
Mapping knowledge of the stem cell in traumatic brain injury: a bibliometric and visualized analysis Open
Background Traumatic brain injury (TBI) is a brain function injury caused by external mechanical injury. Primary and secondary injuries cause neurological deficits that mature brain tissue cannot repair itself. Stem cells can self-renewal …
View article: DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis
DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis Open
Colorectal Carcinoma (CRC) is one of the most common malignant tumors of the digestive tract, with a high mortality rate. DPY30 is one of the core subunits of the histone methyltransferase complex, which was involved in many cancer process…
View article: Prophylactic treatment with <i>Bacteroides uniformis</i> and <i>Bifidobacterium bifidum</i> counteracts hepatic NK cell immune tolerance in nonalcoholic steatohepatitis induced by high fat diet
Prophylactic treatment with <i>Bacteroides uniformis</i> and <i>Bifidobacterium bifidum</i> counteracts hepatic NK cell immune tolerance in nonalcoholic steatohepatitis induced by high fat diet Open
Hepatic immunity is one of the driving forces for the development of nonalcoholic steatohepatitis (NASH), and targeting gut microbiota is believed to affect the hepatic immune constitution. Here, we aimed to investigate the hepatic immunol…
View article: Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids
Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids Open
Retraction of ‘Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids’ by Zhen-Xi Niu et al. , Nat. Prod. Rep. , 2024, https://doi.org/10.1039/d4np00016a.
View article: Crosstalk of cuproptosis-related subtypes, establishment of a prognostic signature, and immune infiltration characteristics in gastric cancer
Crosstalk of cuproptosis-related subtypes, establishment of a prognostic signature, and immune infiltration characteristics in gastric cancer Open
The findings of this study revealed the possible impacts of CRGs on the TME, clinical and pathological characteristics, and outlook of patients with GC. This signature was strongly linked to the immune response against GC and has the poten…
View article: Ru-Loaded Biphasic TiO2 Nanosheet-Tubes Enriched with Ti3+ Defects and Directionally Deficient Electrons as Highly Efficient Catalysts in Benzene Selective Hydrogenation
Ru-Loaded Biphasic TiO2 Nanosheet-Tubes Enriched with Ti3+ Defects and Directionally Deficient Electrons as Highly Efficient Catalysts in Benzene Selective Hydrogenation Open
Crystalline phase engineering is a prominent strategy for synergistically optimizing the surface–body phases of a catalyst. In this work, TiO2 nanosheets assembled into nanotubes (TNSTs) with two phases, anatase and rutile, were firstly sy…
View article: Harmonizing the craft of crafting clinically endorsed small-molecule BCR-ABL tyrosine kinase inhibitors for the treatment of hematological malignancies
Harmonizing the craft of crafting clinically endorsed small-molecule BCR-ABL tyrosine kinase inhibitors for the treatment of hematological malignancies Open
The advancement and practical use of small-molecule tyrosine kinase inhibitors (TKIs) that specifically target the BCR-ABL fusion protein have introduced a revolutionary era of precision medicine for the treatment of chronic myeloid leukem…
View article: Ru Loaded Biphasic TiO2 Nanosheet-Tubes Enriched with Ti3+ Defects and Directionally Deficient Electrons as Highly Efficient Catalysts in Benzene Selective Hydrogenation
Ru Loaded Biphasic TiO2 Nanosheet-Tubes Enriched with Ti3+ Defects and Directionally Deficient Electrons as Highly Efficient Catalysts in Benzene Selective Hydrogenation Open
Crystalline phase engineering is a prominent strategy for synergistically optimizing the sur-face-body phases of a catalyst. In this work, TiO2 nanosheets assembled into nanotubes (TNSTs) with two-phases of anatase and rutile were firstly …
View article: A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications
A Comprehensive Review of Small-Molecule Inhibitors Targeting Bruton Tyrosine Kinase: Synthetic Approaches and Clinical Applications Open
Bruton tyrosine kinase (BTK) is an essential enzyme in the signaling pathway of the B-cell receptor (BCR) and is vital for the growth and activation of B-cells. Dysfunction of BTK has been linked to different types of B-cell cancers, autoi…
View article: Letter to editor ‘Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness’
Letter to editor ‘Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness’ Open
This letter to the editor relates to the study entitled "Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness". Acute bleeding caused by esophageal varices is a life-threatening complication in…
View article: Deletion of the PPARδ gene exacerbates high-fat diet-induced nonalcoholic fatty liver disease in mice through the gut-liver axis
Deletion of the PPARδ gene exacerbates high-fat diet-induced nonalcoholic fatty liver disease in mice through the gut-liver axis Open
Gut microbiota dysbiosis is an essential factor contributing to non-alcoholic fatty liver disease (NAFLD), in which the gut-liver axis plays a crucial role. Peroxisome proliferator-activated receptor δ (PPARδ) is considered a new direction…