Yong Wan
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View article: ENLighten: Lighten the Transformer, Enable Efficient Optical Acceleration
ENLighten: Lighten the Transformer, Enable Efficient Optical Acceleration Open
Photonic computing has emerged as a promising substrate for accelerating the dense linear-algebra operations at the heart of AI, yet adoption for large Transformer models remains in its infancy. We identify two bottlenecks: (1) costly elec…
View article: Portfolio Optimization Based On 6 American Stocks
Portfolio Optimization Based On 6 American Stocks Open
This paper constructs an optimal portfolio and compares the portfolio with the SPDR S&P 500 ETF Trust (SPY) using the maximum Sharpe ratio model. Six stocks from different sectors in the S&P 500 were selected: Apple Inc. (AAPL), JPMorgan C…
View article: Single‐Atom Nano‐Islands: Unlocking New Horizons in Catalytic Activity and Stability
Single‐Atom Nano‐Islands: Unlocking New Horizons in Catalytic Activity and Stability Open
Single‐atom catalysts (SACs), renowned for their maximized atomic utilization, tunable coordination environments, and unique electronic structures, are critical to energy conversion and storage. However, obstacles to their practical perfor…
View article: Hydroxyapatite-reinforced chitosan film on PEO-treated aluminum alloys for enhanced corrosion resistance
Hydroxyapatite-reinforced chitosan film on PEO-treated aluminum alloys for enhanced corrosion resistance Open
View article: Rare recurrence of common bile duct calculi post T-tube cholangiography: A case report
Rare recurrence of common bile duct calculi post T-tube cholangiography: A case report Open
BACKGROUND Recurrence of common bile duct (CBD) calculi within 30 days following T-tube cholangiography is exceedingly rare. CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm × 0.9 cm stone located in …
View article: Collaborative Learning on Data and Model for Semi-Supervised Medical Image Segmentation
Collaborative Learning on Data and Model for Semi-Supervised Medical Image Segmentation Open
View article: The Energy Consumption Comparison of Temperature Difference-based Defrosting Exit Method and Time-based Defrosting Exit Method with Various Static Pressure Differences
The Energy Consumption Comparison of Temperature Difference-based Defrosting Exit Method and Time-based Defrosting Exit Method with Various Static Pressure Differences Open
The time-based defrosting exit method(TDEM) has been widely used in cold storage, but the issue of energy consumption has been heavily criticized. In this paper, a temperature difference-based defrosting exit method(TDDEM) is proposed to c…
View article: Forecasting rheumatoid arthritis patient arrivals by including meteorological factors and air pollutants
Forecasting rheumatoid arthritis patient arrivals by including meteorological factors and air pollutants Open
View article: Unlocking Efficient Hydrogen Production: Nucleophilic Oxidation Reactions Coupled with Water Splitting
Unlocking Efficient Hydrogen Production: Nucleophilic Oxidation Reactions Coupled with Water Splitting Open
Electrocatalytic water splitting driven by sustainable energy is a clean and promising water‐chemical fuel conversion technology for the production of high‐purity green hydrogen. However, the sluggish kinetics of anodic oxygen evolution re…
View article: Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening Open
View article: Abstract 1394 USP10 stabilizes B7-H4 and promotes tumor immune evasion in breast cancer
Abstract 1394 USP10 stabilizes B7-H4 and promotes tumor immune evasion in breast cancer Open
Immunotherapy has revolutionized cancer treatment, yet its efficacy remains suboptimal in 'immune cold' tumors like triple-negative breast cancer (TNBC). Multiomic analyses and experimental validation identified the USP10-B7-H4 proteolytic…
View article: Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening Open
Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Current treatment options are limited and often ineffective. CAR T cell therapy has shown success in treating hematologic malignancies, and …
View article: Effects of Solvent Acid on the Microstructure and Corrosion Resistance of Chitosan Films on Plasma Electrolytic Oxidation Coatings on 5052 Aluminum Alloy
Effects of Solvent Acid on the Microstructure and Corrosion Resistance of Chitosan Films on Plasma Electrolytic Oxidation Coatings on 5052 Aluminum Alloy Open
View article: Measurement of Slip Length and Friction Reduction: An Experimental Study About Boundary Slip Using Omniphobic and 2d Coatings
Measurement of Slip Length and Friction Reduction: An Experimental Study About Boundary Slip Using Omniphobic and 2d Coatings Open
View article: Study on the Current-Carrying Friction Behavior of Crn Coatings Under the Influence of Dc Electric Current Discharge
Study on the Current-Carrying Friction Behavior of Crn Coatings Under the Influence of Dc Electric Current Discharge Open
View article: Measurement of Slip Length and Friction Reduction: An Experimental Study About Boundary Slip Using Omniphobic and 2d Coatings
Measurement of Slip Length and Friction Reduction: An Experimental Study About Boundary Slip Using Omniphobic and 2d Coatings Open
View article: The effect of incremental land expansion and stock land redevelopment on urban economic growth
The effect of incremental land expansion and stock land redevelopment on urban economic growth Open
[Objective] Against the backdrop of tightening incremental land resources, urban development is gradually shifting from relying on the external expansion of incremental land supply to focusing on the intensive model of redevelopment of sto…
View article: TEC-Net: Vision Transformer Embrace Convolutional Neural Networks for Medical Image Segmentation
TEC-Net: Vision Transformer Embrace Convolutional Neural Networks for Medical Image Segmentation Open
The hybrid architecture of convolution neural networks (CNN) and Transformer has been the most popular method for medical image segmentation. However, the existing networks based on the hybrid architecture suffer from two problems. First, …
View article: Data from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Data from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Despite widespread utilization of immunotherapy, treating immune-cold tumors has proved to be a challenge. Here, we report that expression of the immune checkpoint molecule B7-H4 is prevalent among immune-cold triple-negative breast cancer…
View article: Supplementary Figures and Table from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Supplementary Figures and Table from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Supplementary Figures 1-8 Supplementary Table 1
View article: Supplementary Figures and Table from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Supplementary Figures and Table from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Supplementary Figures 1-8 Supplementary Table 1
View article: Supplementary Movie from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Supplementary Movie from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Movie S. AMFR RING (cyan) and B7-H4 dimer complex in 120 ns MD simulations (run 1). Simulations were performed to verify the stability of the complex conformer illustrated in Fig. 4E. B7-H4 Ig-like V-type 1 and Ig-like V-type 2 domains are…
View article: Supplementary Movie from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Supplementary Movie from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Movie S. AMFR RING (cyan) and B7-H4 dimer complex in 120 ns MD simulations (run 1). Simulations were performed to verify the stability of the complex conformer illustrated in Fig. 4E. B7-H4 Ig-like V-type 1 and Ig-like V-type 2 domains are…
View article: Data from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Data from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers Open
Despite widespread utilization of immunotherapy, treating immune-cold tumors has proved to be a challenge. Here, we report that expression of the immune checkpoint molecule B7-H4 is prevalent among immune-cold triple-negative breast cancer…
View article: Data from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations
Data from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations Open
Defining processes that are synthetic lethal with p53 mutations in cancer cells may reveal possible therapeutic strategies. In this study, we report the development of a signal-oriented computational framework for cancer pathway discovery …
View article: Data from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations
Data from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations Open
Defining processes that are synthetic lethal with p53 mutations in cancer cells may reveal possible therapeutic strategies. In this study, we report the development of a signal-oriented computational framework for cancer pathway discovery …
View article: Data from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability
Data from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability Open
EIF3H is presumed to be a critical translational initiation factor. Here, our unbiased screening for tumor invasion factors has identified an unexpected role for EIF3H as a deubiquitylating enzyme that dictates breast tumor invasion and me…
View article: Supplementary Table from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability
Supplementary Table from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability Open
Tab S1 Mass spectry proteins report of F/H-EIF3H purification. Tab S2 Characteristics of breast invasive ductal carcinoma patients
View article: Tabel S2 from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations
Tabel S2 from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations Open
An MS Excel file containing the response modules that are highly informative of patient outcome.
View article: Data from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability
Data from EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP Stability Open
EIF3H is presumed to be a critical translational initiation factor. Here, our unbiased screening for tumor invasion factors has identified an unexpected role for EIF3H as a deubiquitylating enzyme that dictates breast tumor invasion and me…