Yan Qi
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View article: In-host co-colonization and bloodstream infection by distinct classical and hypervirulent CRKP clones harboring a homologous blaKPC-2-harboring plasmid
In-host co-colonization and bloodstream infection by distinct classical and hypervirulent CRKP clones harboring a homologous blaKPC-2-harboring plasmid Open
Carbapenem-resistant Klebsiella pneumoniae (CRKP) readily colonizes clinical environments as well as the respiratory and intestinal tracts of patients and can easily cause secondary infections, posing a serious threat to infection treatmen…
View article: Genome Sequencing and Comparative Genomic Analysis of Multidrug-Resistant Klebsiella pneumoniae in a Neurological Intensive Care Unit
Genome Sequencing and Comparative Genomic Analysis of Multidrug-Resistant Klebsiella pneumoniae in a Neurological Intensive Care Unit Open
NICU K. pneumoniae could colonise patients and the ward air environment for a long time, suggesting that there may be a similar evolutionary or direct transmission relationship between strains. The ST11-KL47 and ST11-KL64 phenotypes were t…
View article: Mitochondrial Regulation of Spermatozoa Function: Metabolism, Oxidative Stress and Therapeutic Insights
Mitochondrial Regulation of Spermatozoa Function: Metabolism, Oxidative Stress and Therapeutic Insights Open
Mitochondria are central to energy production and redox regulation in spermatozoa, supporting key functions such as progressive motility, capacitation, and the acrosome reaction. These processes are essential for successful fertilization a…
View article: Effectiveness of a Mobile Breastfeeding Monitoring Tool Among Mothers in WeChat Groups on Breastfeeding Exclusivity and Self-Efficacy: Intention-to-Treat and Per-Protocol Analyses of a Randomized Controlled Trial
Effectiveness of a Mobile Breastfeeding Monitoring Tool Among Mothers in WeChat Groups on Breastfeeding Exclusivity and Self-Efficacy: Intention-to-Treat and Per-Protocol Analyses of a Randomized Controlled Trial Open
Background Globally, the pursuit of exclusive breastfeeding (EBF) remains a formidable challenge. The surge in popularity of mobile health interventions demonstrates its potential as a promising avenue for promoting breastfeeding practices…
View article: Temporospatial variation in environmental risk factors and related gastric cancer incidence: a registry-based study in an area with the largest gastric cancer burden in China
Temporospatial variation in environmental risk factors and related gastric cancer incidence: a registry-based study in an area with the largest gastric cancer burden in China Open
We observed significant geospatial variations in the ASIR and ASMR of gastric cancer in Gansu Province, which has the highest incidence rate of gastric cancer in China, as well as a novel correlation between the usage of chemical fertilise…
View article: SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule
SIRT3 suppresses vascular endothelial senescence via DHRS2 and contributes to the anti-vascular aging effect of Bazi Bushen capsule Open
SIRT3 activates DHRS2-PKCδ to stop aging in endothelial cells by inhibiting uncoupled eNOS translocating to mitochondria. BZBS rescued vascular aging and endothelial dysfunction via the SIRT3-DHRS2 axis. Revealing a protective mechanism by…
View article: Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173] Open
[This corrects the article DOI: 10.1016/j.apsb.2022.05.019.].
View article: Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation
Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation Open
Adipose-derived stromal cells (ADSCs) are commonly used in regenerative medicine, but the genetic features of their development into neuronal cells are unknown. This study used single-cell RNA sequencing (scRNA-seq) to reveal gene expressi…
View article: Simulation study on the influence of groove depth on the lethal power performance of annular hollow pre controlled fragment warheads
Simulation study on the influence of groove depth on the lethal power performance of annular hollow pre controlled fragment warheads Open
The pre controlled fragment warhead can be applied in certain specific scenarios due to its excellent damage performance and structural integrity. It is widely used in different combat scenarios. In order to obtain the influence of differe…
View article: The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes
The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes Open
The potential of adult adipose-derived stromal cells (ADSCs) to differentiate into astrocytes holds promise for future cell transplantation therapies. However, the growth of differentiated astrocytes is unstable, and their survival rate is…
View article: Biomarkers of mature neuronal differentiation and related diseases
Biomarkers of mature neuronal differentiation and related diseases Open
The nervous system regulates perception, cognition and behavioral responses by serving as the body's primary communication system for receiving, regulating and transmitting information. Neurons are the fundamental structures and units of t…
View article: Effectiveness of a Mobile Breastfeeding Monitoring Tool Among Mothers in WeChat Groups on Breastfeeding Exclusivity and Self-Efficacy: Intention-to-Treat and Per-Protocol Analyses of a Randomized Controlled Trial (Preprint)
Effectiveness of a Mobile Breastfeeding Monitoring Tool Among Mothers in WeChat Groups on Breastfeeding Exclusivity and Self-Efficacy: Intention-to-Treat and Per-Protocol Analyses of a Randomized Controlled Trial (Preprint) Open
BACKGROUND Globally, the pursuit of exclusive breastfeeding (EBF) remains a formidable challenge. The surge in popularity of mobile health interventions demonstrates its potential as a promising avenue for promoting breastfeeding practice…
View article: Association of Metabolic Syndrome or Weather Conditions with the Severity and Prognosis of Sudden Sensorineural Hearing Loss
Association of Metabolic Syndrome or Weather Conditions with the Severity and Prognosis of Sudden Sensorineural Hearing Loss Open
BACKGROUND: It is reported that sudden sensorineural hearing loss (SSNHL) is closely related to diabetes, hypertension, and hyperlipidemia. While the metabolic syndrome (MetS) is a multifactorial disease that includes diabetes, hypertensio…
View article: Endoplasmic reticulum stress and death receptor-mediated apoptosis in the neuronal differentiation of adult adipose-derived stromal cells
Endoplasmic reticulum stress and death receptor-mediated apoptosis in the neuronal differentiation of adult adipose-derived stromal cells Open
Apoptosis is the primary cause of cell death in the differentiation of Adipose-derived stromal cells (ADSCs) into neurons. However, the relationship between endoplasmic reticulum stress (ERS) and death receptor-mediated apoptosis in ADSC-i…
View article: Fibulin7 Mediated Pathological Cardiac Remodeling through EGFR Binding and EGFR‐Dependent FAK/AKT Signaling Activation
Fibulin7 Mediated Pathological Cardiac Remodeling through EGFR Binding and EGFR‐Dependent FAK/AKT Signaling Activation Open
Adverse remodeling after myocardial infarction (MI) result in heart failure and sudden cardiac death. Fibulin7 (FBLN7) is an adhesion protein excreted into the extracellular matrix that functions in multiple biological processes. However, …
View article: The design of TXL-CAP study: a randomized, double-blind, placebo-controlled, multicenter Clinical Trial to assess Tongxinluo Capsule on Coronary Atherosclerotic Vulnerable Plaque
The design of TXL-CAP study: a randomized, double-blind, placebo-controlled, multicenter Clinical Trial to assess Tongxinluo Capsule on Coronary Atherosclerotic Vulnerable Plaque Open
Background Traditional Chinese medicine (TCM) Tongxinluo (TXL) capsules have been widely used in atherosclerosis treatment. Previous studies have demonstrated the TXL can retard the progression of atherosclerosis and reduce the incidence o…
View article: SS31 Alleviates Pressure Overload-Induced Heart Failure Caused by Sirt3-Mediated Mitochondrial Fusion
SS31 Alleviates Pressure Overload-Induced Heart Failure Caused by Sirt3-Mediated Mitochondrial Fusion Open
Heart failure caused by pressure overload is one of the leading causes of heart failure worldwide, but its pathological origin remains poorly understood. It remains critical to discover and find new improvements and treatments for pressure…
View article: Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora
Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora Open
Intestinal flora plays an important role in atherosclerosis. Tongxinluo, as a multi-target Chinese medicine to improve atherosclerosis, whether it can improve atherosclerosis by affecting the intestinal flora is worth exploring. We establi…
View article: Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis
Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis Open
Lymphangiogenesis is possibly capable of attenuating hypertension‐induced cardiac injury. Sirtuin 3 (SIRT3) is an effective mitochondrial deacetylase that has the potential to modulate this process; however, its role in hypertension‐induce…
View article: Melatonin Alleviates Contrast‐Induced Acute Kidney Injury by Activation of Sirt3
Melatonin Alleviates Contrast‐Induced Acute Kidney Injury by Activation of Sirt3 Open
Oxidative stress and apoptosis play a vital role in the pathogenesis of contrast‐induced acute kidney injury (CI‐AKI). The purpose of our study was to investigate the protective effects and mechanisms of melatonin against CI‐AKI in a CI‐AK…
View article: Tetrahydroxystilbene glucoside protects against LPS-induced endothelial dysfunction via inhibiting RhoA/ROCK signaling and F-actin remodeling
Tetrahydroxystilbene glucoside protects against LPS-induced endothelial dysfunction via inhibiting RhoA/ROCK signaling and F-actin remodeling Open
We analyzed the role of the RhoA/ROCK pathway in regulating endothelial dysfunction triggered by LPS and the protective effects of TSG (2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside). Human umbilical vein endothelial cells (HUVECs) we…
View article: Mechanical Properties of Paste Slurry under Constant Shear Rate in Initial Structure Failure Process
Mechanical Properties of Paste Slurry under Constant Shear Rate in Initial Structure Failure Process Open
At constant shear rate, the process of deformation of the paste slurry is divided into two stages: one is the initial structural failure process with increasing shear stress; the other is the thixotropic process with decreasing shear stres…
View article: The Optimization of Mix Proportions for Cement Paste Backfill Materials via Box–Behnken Experimental Method
The Optimization of Mix Proportions for Cement Paste Backfill Materials via Box–Behnken Experimental Method Open
Cemented paste backfill (CPB) technology has been applied quite popular around the world. Determining a reliable filling material mix proportions is an important aspect of mine backfilling. To produce effective CPB materials at copper mine…
View article: Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway
Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway Open
Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotec…
View article: Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway
Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway Open
Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotec…
View article: The relationships of collagen and ADAMTS2 expressionlevels with meat quality traits in cattle
The relationships of collagen and ADAMTS2 expressionlevels with meat quality traits in cattle Open
Extracellular matrix (ECM) is the major macromolecule in skeletal muscle, and collagen is main component of ECM surrounding muscle fiber and adipocyte, which affect meat quality greatly. The remodeling of ECM is regulated by matrix metallo…