Yaw Aniweh
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View article: Trends in insecticide resistance in <i>Anopheles</i> mosquitoes (Diptera: Culicidae) in Ghana: a systematic review
Trends in insecticide resistance in <i>Anopheles</i> mosquitoes (Diptera: Culicidae) in Ghana: a systematic review Open
Malaria continues to be a major public health issue in Ghana, contributing significantly to hospital outpatient visits. Vector control remains central to malaria prevention; however, the growing resistance of malaria vectors to insecticide…
View article: Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release
Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release Open
Preventing malaria parasite transmission to the mosquito vector is a key elimination challenge that could benefit from a diagnostic test that can identify transmission-competent individuals. Only sexual parasite forms, called gametocytes, …
View article: Plasmodium falciparum Subtilisin-like Domain-Containing Protein (PfSDP), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with Plasmodium falciparum
Plasmodium falciparum Subtilisin-like Domain-Containing Protein (PfSDP), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with Plasmodium falciparum Open
With the increasing detection of artemisinin resistance to front-line antimalarials in Africa and notwithstanding the planned roll-out of RTS’S and R21 in Africa, the search for new vaccines with high efficacy remains an imperative. Toward…
View article: Multiple-stage active antimalarial, Cabamiquine, inhibits multiple real-world Plasmodium species with no cross resistance with existing treatments
Multiple-stage active antimalarial, Cabamiquine, inhibits multiple real-world Plasmodium species with no cross resistance with existing treatments Open
Malaria remains a major public health concern in Sub-Saharan Africa. The widespread and emerging drug resistance call for urgent development of new drugs with novel modes of action to treat, control, and eliminate malaria. Cabamiquine, a p…
View article: An expanded method for malaria parasite genetic surveillance using targeted nanopore sequencing
An expanded method for malaria parasite genetic surveillance using targeted nanopore sequencing Open
Malaria causes around 250 million cases and over 600,000 deaths annually, with the heaviest burden falling on young children living in sub-Saharan Africa. Molecular surveillance of Plasmodium parasites and Anopheles mosquito vectors are ke…
View article: <i>Plasmodium falciparum</i> isolates: <i>ex vivo</i> drug response
<i>Plasmodium falciparum</i> isolates: <i>ex vivo</i> drug response Open
Objectives While artemisinin-based combination therapies (ACTs) are effective in sub-Saharan Africa, clinical isolates that are refractory to artemisinin derivatives are emerging in East Africa and ACT partner drugs are becoming less effec…
View article: <em>Plasmodium falciparum</em> Subtilisin-Like Domain Containing Protein ((PfSDP) PF3D7_1105800), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with <em>Plasmodium falciparum</em>
<em>Plasmodium falciparum</em> Subtilisin-Like Domain Containing Protein ((PfSDP) PF3D7_1105800), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with <em>Plasmodium falciparum</em> Open
With the increasing detection of artemisinin resistance to front-line antimalarials in Africa and notwithstanding the planned roll-out of RTS’S and R21 in Africa, the search for new vaccines with high efficacy remains an imperative. Toward…
View article: Differential <i>ex vivo</i> susceptibility of <i>Plasmodium malariae</i> and <i>Plasmodium falciparum</i> clinical isolates from Ghana and Mali to current and lead discovery candidate antimalarial drugs
Differential <i>ex vivo</i> susceptibility of <i>Plasmodium malariae</i> and <i>Plasmodium falciparum</i> clinical isolates from Ghana and Mali to current and lead discovery candidate antimalarial drugs Open
Non-falciparum species causing malaria in humans are considered neglected in the fight toward malaria elimination. Recent data highlight the increasing contribution of Plasmodium malariae to malaria morbidity and mortality. In this study, …
View article: Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates
Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates Open
Gossypol has demonstrated significant antimalarial activity against chloroquine-resistant and susceptible Plasmodium falciparum parasites. However, data on its potency in clinical isolates of P. falciparum remains limited. This study aimed…
View article: scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria Open
Malaria causes significant morbidity and mortality worldwide, disproportionately impacting sub-Saharan Africa. Disease phenotypes associated with Plasmodium falciparum infection can vary widely, from asymptomatic to life-threatening. To da…
View article: Perspective Chapter: The Double Edge Sword – Modulations of Inflammatory Responses – Parasite Survival Strategy or Host Tolerance Mechanisms
Perspective Chapter: The Double Edge Sword – Modulations of Inflammatory Responses – Parasite Survival Strategy or Host Tolerance Mechanisms Open
Parasite organisms, including Plasmodium, Toxoplasma, Leishmania, and Helminths, rely on the host for survival, causing considerable morbidity and mortality in endemic regions. It is generally acknowledged that the clinical symptoms associ…
View article: Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates
Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates Open
Gossypol is known to have good antimalarial activities against chloroquine-resistant and susceptible Plasmodium falciparum parasites. However, there is limited data on its potency in clinical isolates of P. falciparum. Therefore, this stud…
View article: Spatiotemporal Analysis of Plasmodium falciparum Erythrocyte Binding Antigen (Pf EBA) 175 Gene Dimorphism in Ghana
Spatiotemporal Analysis of Plasmodium falciparum Erythrocyte Binding Antigen (Pf EBA) 175 Gene Dimorphism in Ghana Open
Background Malaria remains a leading cause of death worldwide, claiming over 600,000 lives each year. Over 90% of these deaths, mostly among children under five years, occur in sub-Saharan Africa and are caused by Plasmodium falciparum. Th…
View article: Prevalence of Leucocytozoon infection in domestic birds in Ghana
Prevalence of Leucocytozoon infection in domestic birds in Ghana Open
Leucocytozoon is a haemosporidian parasite known to cause leucocytozoonosis in domestic and wild birds in most parts of the world. It is an important pathogen, as some species can be pathogenic, especially in domestic birds. One of the fac…
View article: The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana
The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana Open
Background The routine surveillance of asymptomatic malaria using nucleic acid-based amplification tests is essential in obtaining reliable data that would inform malaria policy formulation and the implementation of appropriate control mea…
View article: Co-infection of Plasmodium falciparum and Schistosoma mansoni is associated with anaemia
Co-infection of Plasmodium falciparum and Schistosoma mansoni is associated with anaemia Open
Background Malaria and schistosomiasis persist as major public health challenge in sub-Saharan Africa. These infections have independently and also in polyparasitic infection been implicated in anaemia and nutritional deficiencies. This st…
View article: A fourth locus in the Plasmodium falciparum genome associated with sickle haemoglobin
A fourth locus in the Plasmodium falciparum genome associated with sickle haemoglobin Open
Heterozygosity for sickle haemoglobin (HbS) confers protection against severe malaria caused by the parasite Plasmodium falciparum. Recent work suggests that this protective effect can depend on the parasite genotype. Here, we performed a …
View article: MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites
MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites Open
The emergence of drug-resistant malaria parasites to artemisinin and its partner drugs highlights the need to increase the arsenal of new antimalarials with novel mechanisms of action. To help achieve this aim, this study tested the potenc…
View article: scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria Open
Malaria causes significant morbidity and mortality worldwide, disproportionately impacting sub-Saharan Africa. Disease phenotypes associated with malarial infection can vary widely, from asymptomatic to life-threatening. To date, preventio…
View article: Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana Open
Current malaria control and elimination tools such as drug treatments are not specifically targeting P.ovale . P. ovale can form hypnozoite and cause relapsing malaria. P. ovale is the third most dominant species in Africa and requires rad…
View article: Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children
Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children Open
The endothelial protein C receptor (EPCR)–rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study…
View article: Comparative analysis of Vibrio cholerae isolates from Ghana reveals variations in genome architecture and adaptation of outbreak and environmental strains
Comparative analysis of Vibrio cholerae isolates from Ghana reveals variations in genome architecture and adaptation of outbreak and environmental strains Open
Recurrent epidemics of cholera denote robust adaptive mechanisms of Vibrio cholerae for ecological shifting and persistence despite variable stress conditions. Tracking the evolution of pathobiological traits requires comparative genomic s…
View article: Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population
Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population Open
Background Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite’s ligands and the erythrocyte surface receptors. While some P. falciparum isolates necessarily engage the sialic acid (SA)…