Yaxian Kong
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View article: Increasing meridional disparity of population exposure to heat stress
Increasing meridional disparity of population exposure to heat stress Open
View article: Therapeutic roles and molecular mechanisms of Cuscutae Semen in reproductive diseases
Therapeutic roles and molecular mechanisms of Cuscutae Semen in reproductive diseases Open
Cuscutae Semen (CS), one of the herbs in traditional Chinese medicine, has been recorded for a long time and contains various bioactive compounds, including flavonoids, phenolic acids, lignans, and polysaccharides. These compounds contribu…
View article: Lactate Dehydrogenase/Albumin to Urea Ratio: A Novel Prognostic Indicator for Adverse Outcomes in Patients With Severe Fever With Thrombocytopenia Syndrome
Lactate Dehydrogenase/Albumin to Urea Ratio: A Novel Prognostic Indicator for Adverse Outcomes in Patients With Severe Fever With Thrombocytopenia Syndrome Open
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with significant mortality risks. This study evaluated the predictive value of the lactate dehydrogenase/albumin to urea ratio (LAU) for lethal outcomes i…
View article: Knockdown of TIM3 Hampers Dendritic Cell Maturation and Induces Immune Suppression by Modulating T-Cell Responses
Knockdown of TIM3 Hampers Dendritic Cell Maturation and Induces Immune Suppression by Modulating T-Cell Responses Open
Various inhibitors targeting T-cell immunoglobulin and mucin-containing molecule 3 (TIM3) aimed at reversing T-cell exhaustion for better immunotherapy outcomes have demonstrated limited clinical efficacy as monotherapy, with the underlyin…
View article: Advancing mechanistic understanding of post-acute sequelae of Ebola virus disease
Advancing mechanistic understanding of post-acute sequelae of Ebola virus disease Open
View article: Crucial analysis of Nef-mediated MHC-I modulation in the maintenance of the HIV-1 reservoir
Crucial analysis of Nef-mediated MHC-I modulation in the maintenance of the HIV-1 reservoir Open
View article: Intermediate Knowledge Enhanced the Performance of N-Amide Coupling Yield Prediction Model
Intermediate Knowledge Enhanced the Performance of N-Amide Coupling Yield Prediction Model Open
Amide coupling is an important reaction widely applied in medicinal chemistry. However, condition recommendation remains a challenging issue due to the broad conditions space. Recently, accurate condition recommendations via machine learni…
View article: FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription
FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription Open
FoxO1 is the key molecular target of YFJP in improving CD8+ T cell senescence in HCC. This study preliminarily clarified the mechanism of YFJP in regulating immunosenescence of HCC.
View article: CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity
CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity Open
Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challeng…
View article: Mechanism of Jiedu Prescription in Hepatocellular Carcinoma: Integrating Network Pharmacology and Experimental Validation
Mechanism of Jiedu Prescription in Hepatocellular Carcinoma: Integrating Network Pharmacology and Experimental Validation Open
Purpose: Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic options. Traditional Chinese medicine (TCM), particularly Yangyin Fuzheng Jiedu Prescription (YFJP), has shown promise in improving p…
View article: Identifying vascular stiffening-sensitive macrophages through integration of single-cell transcriptomics and imaging flow cytometry
Identifying vascular stiffening-sensitive macrophages through integration of single-cell transcriptomics and imaging flow cytometry Open
View article: Intermediate knowledge enhanced the performance of the amide coupling yield prediction model
Intermediate knowledge enhanced the performance of the amide coupling yield prediction model Open
Amide coupling, a key medicinal chemistry reaction, benefits from AI to minimize trial-and-error.
View article: Intermediate Knowledge Enhanced the Performance of N-Amide Coupling Yield Prediction Model
Intermediate Knowledge Enhanced the Performance of N-Amide Coupling Yield Prediction Model Open
Amide coupling is an important reaction widely applied in medicinal chemistry. However, condition recommendation remains a challenging issue due to the broad conditions space. Recently, accurate condition recommendations via machine learni…
View article: Intermediate Knowledge Enhanced the Performance of N-Acylation Yield Prediction Model
Intermediate Knowledge Enhanced the Performance of N-Acylation Yield Prediction Model Open
Acylation is an important reaction widely applied in medicinal chemistry. However, yield optimization remains a challenging issue due to the broad conditions space. Recently, accurate condition recommendations via machine learning have eme…
View article: CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection
CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection Open
Immune overactivation is a hallmark of chronic HIV infection, which is critical to HIV pathogenesis and disease progression. The imbalance of helper T cell (Th) differentiation and subsequent cytokine dysregulation are generally considered…
View article: A Nomogram Prognostic Model for Advanced Hepatocellular Carcinoma Based on the Interaction Between CD8+T Cell Counts and Age
A Nomogram Prognostic Model for Advanced Hepatocellular Carcinoma Based on the Interaction Between CD8+T Cell Counts and Age Open
The nomogram model based on CD8+T cell counts and age accurately assessed the prognosis of patients with advanced HCC and suggested that high CD8+T cell levels are beneficial to the survival of patients with advanced …
View article: Sepsis induces non-classic innate immune memory in granulocytes
Sepsis induces non-classic innate immune memory in granulocytes Open
Secondary infection in patients with sepsis triggers a new wave of inflammatory response, which aggravates organ injury and increases mortality. Trained immunity boosts a potent and nonspecific response to the secondary challenge and has b…
View article: Supplemental Figure 2 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure 2 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
TIGIT+ CD8+ T cells from AML patients retain capacity of proliferation and cytotoxicity.
View article: Supplemental Figure Legends from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure Legends from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
Legends for supplemental figures
View article: Supplemental Figure Legends from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure Legends from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
Legends for supplemental figures
View article: Supplemental Figure 1 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure 1 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
TIGIT expression associates with up-regulation of multiple inhibitory receptors.
View article: Data from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Data from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
Purpose: T-cell immunoglobulin and immunoreceptor tyrosine–based inhibitory motif (ITIM) domain (TIGIT) is a recently identified T-cell coinhibitory receptor. In this study, we aimed to determine the clinical impact of TIGIT in pati…
View article: Supplemental Figure 1 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure 1 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
TIGIT expression associates with up-regulation of multiple inhibitory receptors.
View article: Data from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Data from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
Purpose: T-cell immunoglobulin and immunoreceptor tyrosine–based inhibitory motif (ITIM) domain (TIGIT) is a recently identified T-cell coinhibitory receptor. In this study, we aimed to determine the clinical impact of TIGIT in pati…
View article: Supplemental Figure 2 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Supplemental Figure 2 from T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8<sup>+</sup> T-Cell Exhaustion and Poor Clinical Outcome in AML Patients Open
TIGIT+ CD8+ T cells from AML patients retain capacity of proliferation and cytotoxicity.
View article: CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection
CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection Open
Immune overactivation is a hallmark of chronic HIV infection, which is critical to HIV pathogenesis and disease progression. The imbalance of helper T cell (Th) differentiation and subsequent cytokine dysregulation are generally considered…
View article: CD70 is Accumulated and Characterizes a Subset of Proinflammatory Th1/17/22/GM Lymphocytes&nbsp;During HIV Infection
CD70 is Accumulated and Characterizes a Subset of Proinflammatory Th1/17/22/GM Lymphocytes During HIV Infection Open
View article: Phenotypic and functional alterations of monocyte subsets with aging
Phenotypic and functional alterations of monocyte subsets with aging Open
View article: Elevated Foxp3+ double-negative T cells are associated with disease progression during HIV infection
Elevated Foxp3+ double-negative T cells are associated with disease progression during HIV infection Open
Persistent immune activation, which occurs during the whole course of HIV infection, plays a pivotal role in CD4 + T cells depletion and AIDS progression. Furthermore, immune activation is a key factor that leads to impaired immune reconst…
View article: Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Therapy
Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Therapy Open
Although extensive use of antiretroviral therapy (ART) has made great progress in controlling HIV replication and improving CD4 + T cell recovery, the immune reconstitution remained insufficient in some patients, who were defined as poor i…