Explanipedia

Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways Open

Jing Yan, Jiazheng Cai, Xiaojing Pan, Si Li, Christopher G. Fenton , et al. · 2025

Objectives: Periodontitis is a multifactorial inflammatory disease initiated by pathogenic bacteria, such as Porphyromonas gingivalis. Resolvin D1 (RvD1) plays a pivotal role in inflammation resolution. This study aimed to identify the mec…

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway Open

Zhixiong Jiang, Yating Yang, Jiahui Zhou, Xin Li, Qingqing Meng , et al. · 2025

Background Esophageal squamous cell carcinoma (ESCC) ranks among the most prevalent malignancies of the digestive tract. Due to the absence of obvious symptoms in patients with early-stage ESCC, most cases are diagnosed at advanced stages,…

Hydrogen Sulfide Expression May Affect Ovarian Cancer Progression and Drug Resistance Open

Qiong Zhu, Yi Liu, Juan Zhou, Miduo Tan, Yaxin Xue , et al. · 2025

H₂S overexpression affected the OS and PFS and could also have an impact on the drug resistance of OV. Pan cancer prognosis may vary with H₂S expression.

Subgroup Analysis of a Single-Index Threshold Penalty Quantile Regression Model Based on Variable Selection Open

Hui Qi, Yaxin Xue · 2025

In clinical research, subgroup analysis can help identify patient groups that respond better or worse to specific treatments, improve therapeutic effect and safety, and is of great significance in precision medicine. This article considers…

Design, synthesis and anti-cervical cancer activity of aroylpyrrole-based derivatives as potent histone deacetylase 6 inhibitors Open

Xingjie Wang, Yaxin Xue, Youle Su, Xuetao Yuan, Weiyi Su , et al. · 2025

Aroylpyrrole-based derivative 10g showed an IC 50 of 3.9 nM against HDAC6 and exhibited superior selectivity towards HDAC1 than clinical ACY1215. In vitro , 10g showed potent antiproliferative activity against cervical cancer cells.

Simultaneous seasonal dry/wet signals in eastern and central Asia since the Last Glacial Maximum Open

Simin Peng, Yu Li, Zhansen Zhang, Mingjun Gao, Xiaowen Chen , et al. · 2024

The East Asian monsoon region with the summer precipitation regime and the Mediterranean climate region with the winter precipitation regime show opposite dry/wet changes since the Last Glacial Maximum (LGM). Therefore, different precipita…

Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period Open

Henning Hvid, Sara Toftegaard Hjuler, Pierre Bédossa, Dina Tiniakos, Ioannis Kamzolas , et al. · 2024

The physiology and metabolism of pigs have a relatively high resemblance to humans. This study characterizes a new animal model of MASLD/MASH using CDAHFD-fed Göttingen Minipigs. Göttingen Minipigs fed CDAHFD gained weight and developed he…

Genomic insights into redox-driven microbial processes for carbon decomposition in thawing Arctic soils and permafrost Open

Yaoming Li, Yaxin Xue, Taniya Roy Chowdhury, David E. Graham, Susannah G. Tringe , et al. · 2024

Climate change is rapidly transforming Arctic landscapes where increasing soil temperatures speed up permafrost thaw. This exposes large carbon stocks to microbial decomposition, possibly worsening climate change by releasing more greenhou…

Tracing seasonal signals in dry/wet status for regions with simultaneous rain and heat from Eastern and Central Asia since the Last Glacial Maximum Open

Simin Peng, Yu Li, Zhansen Zhang, Mingjun Gao, Xiaowen Chen , et al. · 2023

The global monsoon region with the summer precipitation regime and the Mediterranean climate region with the winter precipitation regime showed opposite dry/wet evolution since the Last Glacial Maximum (LGM). The remarkable difference in s…

Phased human-nature interactions for the past 10 000 years in the Hexi Corridor, China Open

Yu Li, Mingjun Gao, Zhansen Zhang, Junjie Duan, Yaxin Xue · 2023

Located in the eastern section of the ancient Silk Road, the Hexi Corridor is a crucial area where eastern and western civilizations met. Previous studies mainly explore human-nature interactions at a particular period, and there is a lack…

Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362 Open

Huawei Lv, Haibo Su, Yaxin Xue, Jia Jia, Hongkai Bi , et al. · 2023

Current situation and development of facial prosthesis Open

Xin Li, Jia Xu, Jiajun Fan, Yaxin Xue, Xiaoding Gu , et al. · 2023

Facial prostheses have developed significantly in the last 10 years, especially between 2016 and 2021. This development is mainly due to the great progress made in the fields of biocompatible materials, digital technology, and three-dimens…

Additional file 1 of Estimation of average treatment effect based on a multi-index propensity score Open

Jiaqin Xu, Kecheng Wei, Ce Wang, Chen Huang, Yaxin Xue , et al. · 2023

Additional file 1: Fig. S1. The distribution of the estimated average treatment effect for kernel-based MiPS estimator and artificial neural network-based MiPS estimator in 1000 simulated data sets. The range of the y-axis is restricted fr…

Estimation of average treatment effect based on a multi-index propensity score Open

Jiaqin Xu, Kecheng Wei, Ce Wang, Chen Huang, Yaxin Xue , et al. · 2022

Sulfur-containing benzofurans and α-pyrones from the mangrove-derived fungus Talaromyces sp. WHUF0341 Open

Ruohan Zhang, Jinxin Zhang, Ruiyun Huo, Yaxin Xue, Kui Hong , et al. · 2022

Two new sulfur-containing benzofurans, talarobenzofurans A and B ( 1 and 2 ), one new benzofuran talarobenzofuran C ( 3 ) and two new α -pyrones talaropyrones A and B ( 5 and 6 ), along with five known compounds eurothiocin A ( 4 ), noduli…

Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable? Open

Rune Nielsen, Yaxin Xue, Inge Jonassen, Ingvild Haaland, Øyvind Kommedal , et al. · 2021

Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer Open

Yunyun Lan, Juan Su, Yaxin Xue, Lulu Zeng, Xun Cheng , et al. · 2021

Background. Breast cancer (BRCA) is one of the most common cancers and the leading cause of cancer-related death in women. RNA-binding proteins (RBPs) play an important role in the emergence and pathogenesis of tumors. The target RNAs of R…

Three New Metabolites From the Marine-Derived Fungus <i>Aspergillus</i> sp. WHUF03110 Open

Huawei Lv, Kebo Wang, Yaxin Xue, Jun Chen, Haibo Su , et al. · 2021

Two new xanthone derivatives, spinosusones A (1) and B (2), and a new tryptoquivaline analogue, asperdiazapinone G (3), together with nine known compounds (4-12) were isolated from the EtOAc extract of the marine-derived fungus Aspergillus…

Metagenomic tools in microbial ecology research Open

Neslihan Taş, Anniek E. E. de Jong, Yaoming Li, Gareth Trubl, Yaxin Xue , et al. · 2021

New Ophiobolins from the Deep-Sea Derived Fungus Aspergillus sp. WHU0154 and Their Anti-Inflammatory Effects Open

Wenjuan Ding, Chokkalingam Uvarani, Fangfang Wang, Yaxin Xue, Ning Wu , et al. · 2020

Deep-sea fungi have become a new arsenal for the discovery of leading compounds. Here five new ophiobolins 1–5, together with six known analogues 6–11, obtained from a deep-sea derived fungus WHU0154. Their structures were determined by an…

Development and application of computational methods for NGS-based microbiome research Open

Yaxin Xue · 2020

The advance of DNA sequencing technologies has dramatically expanded our knowledge of microbial community composition and their functions from diverse environments. The most common Next Generation Sequencing (NGS)-based methods used for th…

Metagenome-assembled genome distribution and key functionality highlight importance of aerobic metabolism in Svalbard permafrost Open

Yaxin Xue, Inge Jonassen, Lise Øvreås, Neslihan Taş · 2020

Permafrost underlies a large portion of the land in the Northern Hemisphere. It is proposed to be an extreme habitat and home for cold-adaptive microbial communities. Upon thaw permafrost is predicted to exacerbate increasing global temper…

Reconstructing ribosomal genes from large scale total RNA meta-transcriptomic data Open

Yaxin Xue, Anders Lanzén, Inge Jonassen · 2020

Motivation Technological advances in meta-transcriptomics have enabled a deeper understanding of the structure and function of microbial communities. ‘Total RNA’ meta-transcriptomics, sequencing of total reverse transcribed RNA, provides a…

Bacterial and Archaeal Metagenome-Assembled Genome Sequences from Svalbard Permafrost Open

Yaxin Xue, Inge Jonassen, Lise Øvreås, Neslihan Taş · 2019

Permafrost contains one of the least known soil microbiomes, where microbial populations reside in an ice-locked environment. Here, 56 prokaryotic metagenome-assembled genome (MAG) sequences from 13 phyla are reported. These MAGs will prov…

FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function Open

Liang Wang, Ziyi Yan, Helena Vihinen, Ove Eriksson, Weihuan Wang , et al. · 2018

Mitochondrial function is closely linked to its dynamic membrane ultrastructure. The mitochondrial inner membrane (MIM) can form extensive membrane invaginations known as cristae, which contain the respiratory chain and ATP synthase for ox…

Protected sampling is preferable in bronchoscopic studies of the airway microbiome Open

Rune Grønseth, Christine Drengenes, Harald G. Wiker, Solveig Tangedal, Yaxin Xue , et al. · 2017

The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with small-volume lavage (SVL) t…

SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes Open

Yue Shen, Giovanni Stracquadanio, Yun Wang, Kun Yang, Leslie A. Mitchell , et al. · 2015

Synthetic chromosome rearrangement and modification by loxP -mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome ar…

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